Fraction from wax apple [Syzygium Samarangense (Blume) Merrill and Perry] fruit extract ameliorates insulin resistance via modulating insulin signaling and inflammation pathway in tumor necrosis factor α-treated FL83B mouse hepatocytes

International Journal of Molecular Sciences

Volumn 13, Issue 7, 2012, Pages 8562-8577

  Shen, Szu Chuan ^a   Chang, Wen Chang ^b   Chang, Chiao Li ^b  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Glucose uptake; Inflammation; Insulin resistance; Wax apple; Western blot

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYZYGIUM SAMARANGENSE EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; SLC2A2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FRUIT; GLUCOSE TRANSPORT; INFLAMMATION; INSULIN RESISTANCE; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYZYGIUM; SYZYGIUM SAMARANGENSE; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; IMMUNOLOGY; METABOLISM; MYRTACEAE; PHYSIOLOGY;

MALUS X DOMESTICA; SYZYGIUM SAMARANGENSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; FRUIT; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HEPATOCYTES; INSULIN; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MYRTACEAE; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864375387     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13078562     Document Type: Article

References (48)

1. World Health Organization, 2012. Available online: http://www.who.int/diabetes/en/index.html (accessed on 17 May 2012).
2. Ferrannini, E. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects. Endocr. Rev. 1998, 19, 477-490.
3. Saltiel, A.R.; Kahn, C.R. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 2001, 414, 799-806.
4. Coletta, D.K.; Mandarino, L.J. Mitochondrial dysfunction and insulin resistance from the outside in: Extracellular matrix, the cytoskeleton, and mitochondria. Am. J. Physiol. Endocrinol. Metab. 2011, 301, E749-E755.
5. Hotamisligil, G.S. Inflammatory pathways and insulin action. Int. J. Obes. Relat. Metab. Disord. 2003, 27, S53-S55.
6. Nilsson-Öhman, J.; Fredrikson, G.N.; Nilsson-Berglund, L.M.; Gustavsson, C.; Bengtsson, E.; Smith, M.; Agardh, C.; Agardh, E.; Jovinge, S.; Gomez, M.F. et al. Tumor necrosis factor-α does not mediate diabetes-induced vascular inflammation in mice. Arterioscler Thromb. Vasc. Biol. 2009, 29, 1465-1470.
7. Gurib-Fakim, A. Phytochemical screening of 38 mauritian medicinal plants. Revue Agricole et Sucrière de l'lle Maurice 1991, 69, 42-50.
8. Neergheen, V.; Soobrattee, M.; Bahorun, T.; Aruoma, O. Characterization of the phenolic constituents in Mauritian endemic plants as determinants of their antioxidant activities in vitro. J. Plant Physiol. 2006, 163, 787-799.
9. Shen, S.C.; Cheng, F.C.; Wu, N.J. Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. Phytother. Res. 2008, 22, 1458-1464.
10. Cheng, F.C.; Shen, S.C.; Wu, J.S.B. Effect of guava (Psidium guajava L.) leaf extract on glucose uptake in rat hepatocytes. J. Food Sci. 2009, 74, H132-H138.
11. Nonaka, G.; Aiko, Y.; Aritake, K.; Nishioka, I. Tannins and related compounds. CXIX. Samarangenins a and b, novel proanthocyanidins with doubly bonded structures, from Syzygium samarangens and S. aqueum. Chem. Pharm. Bull. 1992, 40, 2671-2673.
12. Kuo, Y.C.; Yang, L.M.; Lin, L.C. Isolation and inmunomodulatory effects of flavonoids from Syzygium samarangense. Planta Med. 2004, 70, 1237-1239.
13. Nair, A.; Krishnan, S.; Ravikrishna, C.; Madhusudanan, K. New and rare flavonol glycosides from leaves of Syzygium samarangense. Fitoterapia 1999, 70, 148-151.
14. Srivastava, R.; Shaw, A.; Kulshreshtha, D. Triterpenoids and chalcone from Syzygium samarangense. Phytochemistry 1995, 38, 687-689.
15. Resurreccion-Magno, M.; Villasenor, I.; Harada, N.; Monde, K. Antihyperglycaemic flavonoids from Syzygium samarangense (Blume) Merr. and Perry. Phytother. Res. 2005, 19, 246-251.
16. Wong, K.; Lai, F. Volatile constituents from the fruits of four Syzygium species grown in Malaysia. Flavour Fragr. J. 1996, 11, 61-66.
17. Tsao, R.; Deng, Z. Separation procedures for naturally occurring antioxidant phytochemicals. J. Chromatogr. B 2004, 812, 85-99.
18. Peraldi, P.; Xu, M.; Spiegelman, B.M. Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin singaling. J. Clin. Invest. 1996, 100, 1863-1869.
19. Moller, D.E. Potential role of TNF-R in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 2000, 6, 212-217.
20. Cheung, A.T.; Wang, J.; Ree, D.; Kolls, J.K.; Bryer-Ash, M. Tumor necrosis factor-R induces hepatic insulin resistance in obese zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase. Diabetes 2000, 49, 810-819.
21. Jung, E.H.; Kim, S.R.; Hwang, I.K.; Ha, T.Y. Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice. J. Agric. Food Chem. 2007, 55, 9800-9804.
22. Czinner, E.; Hagymasi, K.; Blazovics, A.; Kery, A.; Szoke, E.; Lemberkovics, E. In vitro antioxidant properties of Helichrysum arenarium (L.) Moench. J. Ethnopharmacol. 2000, 73, 437-443.
23. Bjornholm, M.; Zierath, J.R. Insulin signal transduction in human skeletal muscle: Identifying the defects in type II diabetes. Biochem. Soc. Trans. 2005, 33, 354-357.
24. Zick, Y. Insulin resistance: A phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 2001, 11, 437-441.
25. White, M.F. Insulin signaling in health and disease. Science 2003, 302, 1710-1711.
26. Shahid, G.; Hussain, T. GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. J. Biol. Chem. 2007, 282, 20612-20620.
27. Rui, L.; Aguirre, V.; Kim, J.K.; Shulman, G.I.; Lee, A.; Corbould, A.; Dunaif, A.; White, M.F. Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J. Clin. Invest. 2001, 107, 181-189.
28. Dearth, R.K.; Cui, X.; Kim, H.J.; Hadsell, D.L.; Lee, A.V. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle 2007, 6, 705-713.
29. Yenush, L.; White, M.F. The IRS-signalling system during insulin and cytokine action. Bioessays 1997, 19, 491-500.
30. Moeschel, K.; Beck, A.; Weigert, C.; Lammers, R.; Kalbacher, H.; Voelter, W.; Schleicher, E.D.; Häring, H.; Lehmann, R. Protein kinase C-δ-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J. Biol. Chem. 2004, 279, 25157-25163.
31. Benito, M. Tissue specificity on insulin action and resistance: Past to recent mechanism. Acta Physiol. 2011, 201, 297-312.
32. Hotamisligil, G.S.; Peraldi, P.; Budvari, A.; Ellis, R.W.; White, M.F. Spiegelman BM: IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance. Science 1996, 271, 665-668.
33. Czech, M.P.; Corvera, S. Signaling mechanisms that regulate glucose transport. J. Biol. Chem. 1999, 74, 1865-1868.
34. Nikoulina, S.E.; Ciaraldi, T.P.; Carter, L.; Mudaliar, S.; Park, K.S.; Henry, R.R. Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation. J. Clin. Endocrinol. Metab. 2001, 86, 4307-4314.
35. Cichy, S.B.; Uddin, S.; Danilkovich, A.; Guo, S.; Klippel, A.; Unterman, T.G. Protein kinase B/Akt mediates effect of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence. J. Biol. Chem. 1998, 273, 6482-6487.
36. Maleppillil, V.V.; Sandeep, S.; Rishi, R.C. The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signaling pathway. Br. J. Pharm. 2005, 146, 41-48.
37. Zhou, L.; Sell, H.; Eckardt, K.; Yang, Z.; Eckel, J. Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS Lett. 2007, 581, 4303-4308.
38. Guitton, C.; Cottereau, A.; Gérard, N.; Quillard, T.; Chauveau, A.; Devallière, J.; Tonnerre, P.; Charreau, B. Protective crosstalk between activated protein C and TNF signaling in vascular endothelial cells: Implication of EPCR, non canonical NFκB and ERK1/2 MAPKinases. J. Physiol. Cell Physiol. 2011, 300, C833-C842.
39. Joost, H.G.; Bell, G.I.; Best, J.D.; Birnbaum, M.J.; Charron, M.J.; Chen, Y.T.; Doege, H.; James, D.E.; Lodish, H.F.; Moley, K.H. Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am. J. Physiol. 2002, 282, E974-E976.
40. Thorens, B.; Cheng, Z.Q.; Brown, D.; Lodish, H.F. Liver glucose transporter: A basolateral protein in hepatocytes and intestine and kidney cells. Am. J. Physiol. 1990, 259, C279-C285.
41. James, D.E. The mammalian facilitative glucose transporter family. Int. Union Physiol. Sci. 1995, 10, 67-71.
42. Luca, C.D.; Olefsky, J.M. Inflammation and insulin resistance. FEBS Lett. 2008, 582, 97-105.
43. Chang, L.; Karin, M. Mammalian MAP kinase signaling cascades. Nature 2001, 410, 37-40.
44. Barreiro, G.C.; Prattali, R.R.; Caliseo, C.T.; Fugiwara, F.Y.; Ueno, M.; Prada, P.O.; Velloso, L.A.; Saad, M.J.A.; Carvalheira, J.B.C. Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats. Biochem. Biophys. Res. Commun. 2004, 320, 992-997.
45. Li, R.W.; Theriault, A.G.; Au, K.; Douglas, T.D.; Casaschi, A.; Kurowska, E.M.; Mukherjee, R. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters. Life Sci. 2006, 79, 365-373.
46. Chang, W.C.; Shen, S.C. Effect of water extracts from edible Myrtaceae plants on uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Phytother. Res. 2012, doi:10.1002/ptr.4681.
47. Singleton, V.L.; Orthofer, R.; Lamuela-Raventos, R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin Ciocalteu agent. Methods Enzymol. 1999, 299, 152-178.
48. Zhishen, J.; Mengcheng, T.; Jianming, W. The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999, 64, 555-559.