Ultrasensitive detection of scrapie prion protein derived from ARQ and AHQ homozygote sheep by interspecies in vitro amplification

Microbiology and Immunology

Volumn 56, Issue 8, 2012, Pages 541-547

  Murayama, Yuichi ^a   Imamura, Morikazu ^a   Masujin, Kentaro ^a   Shimozaki, Noriko ^a   Yoshioka, Miyako ^a   Mohri, Shirou ^a   Yokoyama, Takashi ^a  

^a NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Interspecies amplification; Prion gene polymorphism; Protein misfolding cyclic amplification; Scrapie prion protein

Indexed keywords

POLYANION; PRION PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CODON; CONTROLLED STUDY; COW; DNA POLYMORPHISM; GENE AMPLIFICATION; GENE FREQUENCY; GENOTYPE; GOAT; HAMSTER; HOMOZYGOTE; IN VITRO STUDY; MOUSE; NONHUMAN; OPEN READING FRAME; PRION DISEASE; PROTEIN ANALYSIS; PROTEIN FOLDING; SCRAPIE; SHEEP; SPECIES DIFFERENCE; WESTERN BLOTTING;

ANIMALS; BRAIN CHEMISTRY; GENOTYPE; HOMOZYGOTE; MICE; PRIONS; SCRAPIE; SHEEP;

OVIS ARIES; SCRAPIE PRION;

EID: 84864372857     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2012.00472.x     Document Type: Article

References (48)

1. Prusiner S.B. (1982) Novel proteinaceous infectious particles cause scrapie. Science 216 : 136-44.
2. Prusiner S.B. (1998) Prions. Proc Natl Acad Sci U S A 95 : 13363-83.
3. Mead S. (2006) Prion disease genetics. Eur J Hum Genet 14 : 273-81.
4. Baylis M., Goldmann W. (2004) The genetics of scrapie in sheep and goats. Curr Mol Med 4 : 385-96.
5. Johnson C.J., Herbst A., Duque-Velasquez C., Vanderloo J.P., Bochsler P., Chappell R., McKenzie D. (2011) Prion protein polymorphisms affect chronic wasting disease progression. PLoS One 6 : e17450.
6. Goldmann W., Hunter N., Smith G., Foster J., Hope J. (1994) PrP genotype and agent effects in scrapie: Change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol 75 : 989-95.
7. Belt P.B., Muileman I.H., Schreuder B.E., Bos-de Ruijter J., Gielkens A.L., Smits M.A. (1995) Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. J Gen Virol 76 : 509-17.
8. Hunter N. (1997) PrP genetics in sheep and the applications for scrapie and BSE. Trends Microbiol 5 : 331-4.
9. Dawson M., Hoinville L.J., Hosie B.D., Hunter N. (1998) Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Vet Rec 142 : 623-5.
10. Dubois M.A., Sabatier P., Durand B., Calavas D., Ducrot C., Chalvet-Monfray K. (2002) Multiplicative genetic effects in scrapie disease susceptibility. C R Biol 325 : 565-70.
11. Baylis M., Chihota C., Stevenson E., Goldmann W., Smith A., Sivam K., Tongue S., Gravenor M.B. (2004) Risk of scrapie in British sheep of different prion protein genotype. J Gen Virol 85 : 2735-40.
12. Vitezica Z.G., Elsen J.M., Rupp R., Diaz C. (2005) Using genotype probabilities in survival analysis: A scrapie case. Genet Sel Evol 37 : 403-15.
13. Benestad S.L., Sarradin P., Thu B., Schönheit J., Tranulis M.A., Bratberg B. (2003) Cases of scrapie with unusual features in Norway and designation of a new type, Nor98. Vet Rec 153 : 202-8.
14. Buschmann A., Biacabe A.G., Ziegler U., Bencsik A., Madec J.Y., Erhardt G., Lühken G., Baron T., Groschup M.H. (2004) Atypical scrapie cases in Germany and France are identified by discrepant reaction patterns in BSE rapid tests. J Virol Methods 117 : 27-36.
15. Le Dur A., Béringue V., Andréoletti O., Reine F., Laï T.L., Baron T., Bratberg B., Vilotte J.L., Sarradin P., Benestad S.L., Laude H. (2005) A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A 102 : 16031-6.
16. Buschmann A., Lühken G., Schultz J., Erhardt G., Groschup M.H. (2004) Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR). J Gen Virol 85 : 2727-33.
17. Madec J.Y., Simon S., Lezmi S., Bencsik A., Grassi J., Baron T. (2004) Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock. J Gen Virol 85 : 3483-6.
18. Orge L., Galo A., Machado C., Lima C., Ochoa C., Silva J., Ramos M., Simas J.P. (2004) Identification of putative atypical scrapie in sheep in Portugal. J Gen Virol 85 : 3487-91.
19. Moum T., Olsaker I., Hopp P., Moldal T., Valheim M., Moum T., Benestad S.L. (2005) Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases. J Gen Virol 86 : 231-5.
20. De Bosschere H., Roels S., Dechamps P., Vanopdenbosch E. (2007) TSE detected in a Belgian ARR-homozygous sheep via active surveillance. Vet J 173 : 449-51.
21. Saborio G.P, Permanne B., Soto C. (2001) Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411 : 810-13.
22. Soto C., Anderes L., Suardi S., Cardone F., Castilla J., Frossard M.J., Peano S., Saá P., Limido L., Carbonatto M., Ironside J., Torres J.M., Pocchiari M., Tagliavini F. (2005) Pre-symptomatic detection of prions by cyclic amplification of protein misfolding. FEBS Lett 579 : 638-42.
23. Saá P., Castilla J., Soto C. (2006) Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification. J Biol Chem 281 : 35245-52.
24. Murayama Y., Yoshioka M., Yokoyama T., Iwamaru Y., Imamura M., Masujin K., Yoshiba S., Mohri S. (2007) Efficient in vitro amplification of a mouse-adapted scrapie prion protein. Neurosci Lett 413 : 270-3.
25. RES. J Virol 81 : 9605-8.
26. Sc derived from the brain and blood of sheep infected with scrapie. J Gen Virol 89 : 3177-84.
27. Sc. PLoS One 5 : e13152.
28. Sc. J Pathol 213 : 21-6.
29. Maddison B.C., Baker C.A., Rees H.C., Terry L.A., Thorne L., Bellworthy S.J., Whitelam G.C., Gough K.C. (2009) Prions are secreted in milk from clinically normal scrapie-exposed sheep. J Virol 83 : 8293-6.
30. Gough K.C., Baker C.A., Taema M., Maddison B.C. (2009) In vitro amplification of prions from milk in the detection of subclinical infections. Prion 3 : 236-9.
31. Maddison B.C., Rees H.C., Baker C.A., Taema M., Bellworthy S.J., Thorne L., Terry L.A., Gough K.C. (2010) Prions are secreted into the oral cavity in sheep with preclinical scrapie. J Infect Dis 201 : 1672-6.
32. Bucalossi C., Cosseddu G., D'Agostino C., Di Bari M.A., Chiappini B., Conte M., Rosone F., De Grossi L., Scavia G., Agrimi U., Nonno R., Vaccari G. (2011) Assessment of the genetic susceptibility of sheep to scrapie by PMCA and comparison with experimental scrapie transmission studies. J Virol 85 : 8386-92.
33. Green K.M., Castilla J., Seward T.S., Napier D.L., Jewell J.E., Soto C., Telling G.C. (2008) Accelerated high fidelity prion amplification within and across prion species barriers. PLoS Pathog 4 : e1000139.
34. Sc replication in vitro generates unique infectious prions. Cell 134 : 757-68.
35. Sc generated by interspecies in vitro amplification exhibit distinct pathological and biochemical properties in tga20 transgenic mice. Microbiol Immunol 55 : 331-40.
36. Kurt T.D., Seelig D.M., Schneider J.R., Johnson C.J., Telling G.C., Heisey D.M., Hoover E.A. (2011) Alteration of the chronic wasting disease species barrier by in vitro prion amplification. J Virol 85 : 8528-37.
37. TSE) in skeletal muscles of white-tailed deer infected with chronic wasting disease. PLoS One 6 : e18345.
38. Yokoyama T., Masujin K., Schmerr M.J., Shu Y, Okada H., Iwamaru Y., Imamura M., Matsuura Y., Murayama Y., Mohri S. (2010) Intraspecies prion transmission results in selection of sheep scrapie strains. PLoS One 5 : e15450.
39. Hayashi H., Takata M., Iwamaru Y., Ushiki Y., Kimura K.M., Tagawa Y., Shinagawa M., Yokoyama T. (2004) Effect of tissue deterioration on postmortem BSE diagnosis by immunobiochemical detection of an abnormal isoform of prion protein. J Vet Med Sci 66 : 515-20.
40. Shimizu Y., Kaku-Ushiki Y., Iwamaru Y., Muramoto T., Kitamoto T., Yokoyama T., Mohri S., Tagawa Y. (2010) A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells. Microbiol Immunol 54 : 112-21.
41. Iwamaru Y., Shimizu Y., Imamura M., Murayama Y., Endo R., Tagawa Y., Ushiki-Kaku Y., Takenouchi T., Kitani H., Mohri S., Yokoyama T., Okada H. (2008) Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation. J Neurochem 107 : 636-46.
42. Deleault N.R., Lucassen R.W., Supattapone S. (2003) RNA molecules stimulate prion protein conversion. Nature 425 : 717-20.
43. Yokoyama T., Takeuchi A., Yamamoto M., Kitamoto T., Ironside J.W., Morita M. (2011) Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease. Neurosci Lett 498 : 119-23.
44. Deleault N.R., Kascsak R., Geoghegan J.C., Supattapone S. (2010) Species-dependent differences in cofactor utilization for formation of the protease-resistant prion protein in vitro. Biochemistry 49 : 3928-34.
45. Fraser H., Dickinson A.G. (1973) Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. J Comp Pathol 83 : 29-40.
46. Kimberin R.H., Walker C.A., Fraser H. (1989) The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. J Gen Virol 70 : 2017-25.
47. Beck K.E., Sallis R.E., Lockey R., Simmons M.M., Spiropoulos J. (2010) Ovine PrP genotype is linked with lesion profile and immunohistochemistry patterns after primary transmission of classical scrapie to wild-type mice. J Neuropathol Exp Neurol 69 : 483-97.
48. Beck K.E., Cawthraw S., Saunders G.C., Ellis R., Spiropoulos J. (2011) Transmission of classical scrapie to wild-type mice: the influence of the ovine PrP sequence on lesion profiles. Arch Virol 156 : 903-6.