Ovine PrP genotype is linked with lesion profile and immunohistochemistry patterns after primary transmission of classical scrapie to wild-type mice

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 5, 2010, Pages 483-497

  Beck, Katy E ^a   Sallis, Rosemary E ^a   Lockey, Richard ^a   Simmons, Marion M ^a   Spiropoulos, John ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

Immunohistochemistry; Lesion profile; Mouse bioassay; Prion; Scrapie

Indexed keywords

PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CLUSTER ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE TRANSMISSION; EXPERIMENTAL MOUSE; GENOTYPE; IMMUNOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCRAPIE; SHEEP; WILD TYPE;

ANIMALS; BRAIN; CELL COUNT; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; GENOTYPE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONS; PRPSC PROTEINS; RECEPTORS, IGG; RETROSPECTIVE STUDIES; SCRAPIE; SHEEP;

EID: 77951877660     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181db2497     Document Type: Article

References (26)

1. Pan KM, Baldwin MF, Nguyen JF, et al. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci USA 1993;90:10962-10966
2. Brown P, Bradley R. 1755 and all that: A historical primer of transmissible spongiform encephalopathy. BMJ 1998;317:1688-1692
3. Foster JD, Hope J, Fraser H. Transmission of bovine spongiform encephalopathy to sheep and goats. Vet Rec 1993;133:339-341
4. Bellworthy SJ, Dexter G, Stack M, et al. Natural transmission of BSE between sheep within an experimental flock. Vet Rec 2005;157:206
5. Hunter N, Bossers A. The PrP genotype as a marker for scrapie susceptibility in sheep. In: Hörnlimann B, Riesner D, Kretzschmar H, eds. Prions in Humans and Animals. Berlin, Germany: de Gruyter, 2006: 640-647
6. Belt PB, Muileman IH, Schreuder BE, et al. Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. J Gen Virol 1995;76:509-517
7. Clouscard C, Beaudry P, Elsen JM, et al. Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie. J Gen Virol 1995;76:2097-2101
8. Goldmann W, Hunter N, Smith G, et al. PrP genotype and agent effects in scrapie: Change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol 1994;75:989-995
9. Westaway D, Zuliani V, Cooper CM, et al. Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie. Genes Dev 1994;8:959-969
10. Polymenidou M, Stoeck K, Glatzel M, et al. Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease. Lancet Neurol 2005;4:805-814
11. Bruce ME. Scrapie strain variation and mutation. Br Med Bull 1993;49: 822-838
12. Westaway D, Goodman PA, Mirenda CA, et al. Distinct prion proteins in short and long scrapie incubation period mice. Cell 1987;51:651-662
13. Bruce ME, McConnell I, Fraser H, et al. The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: Implications for the nature of the agent and host control of pathogenesis. J Gen Virol 1991;72:595-603
14. Fraser H, Dickinson AG. The sequential development of the brain lesion of scrapie in three strains of mice. J Comp Pathol 1968;78:301-311
15. Brown DA, Bruce ME, Fraser JR. Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) in mice. Neuropathol Appl Neurobiol 2003;29:262-272
16. Bruce ME, Will RG, Ironside JW, et al. Transmissions to mice indicate that Bnew variant[CJD is caused by the BSE agent. Nature 1997;389: 498-501
17. Bruce ME, Boyle A, Cousens S, et al. Strain characterization of natural sheep scrapie and comparison with BSE. J Gen Virol 2002;83:695-704
18. Green R, Horrocks C, Wilkinson A, et al. Primary isolation of the bovine spongiform encephalopathy agent in mice: Agent definition based on a review of 150 transmissions. J Comp Pathol 2005;132:117-131
19. Beck KE, Chaplin M, Stack M, et al. Lesion profiling at primary isolation in RIII mice is insufficient in distinguishing BSE from classical scrapie. Brain Pathol 2010;20:313-322
20. Bruce ME, Boyle A, McConnell I. TSE strain typing in mice. In: Lehmann S, Grassi J, eds. Techniques in Prion Research. Basel, Switzerland: Birkhäuser Verlag, 2004:132-146
21. Community Reference Laboratory. Fixation, Tissue Processing, Histology and Immunohistochemistry Staining Procedures. Updated March 2009. Available at: http://www.defra.gov.uk/vla/science/docs/sci- tse-rl-prp-ihc.pdf. Accessed March 22, 2010
22. Spiropoulos J, Casalone C, Caramelli M, et al. Immunohistochemistry for PrPSc in natural scrapie reveals patterns which are associated with the PrP genotype. Neuropathol Appl Neurobiol 2007;33:398-409
23. Fielding A. Cluster analysis. In: Cluster and Classification Techniques for the Biosciences. New York, NY: Cambridge University Press, 2007: 46-77
24. Manolakou K, Beaton J, McConnell I, et al. Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice. Proc Natl Acad Sci USA 2001;98:7402-7407
25. Bruce ME. TSE strain variation: An investigation into prion disease diversity. Br Med Bull 2003;66:99-108
26. Thackray AM, Hopkins L, Spiropoulos J, et al. Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice. J Virol 2008;82: 11197-11207