Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies

Journal of Virology

Volumn 85, Issue 16, 2011, Pages 8386-8392

  Bucalossi, Cecilia ^a   Cosseddu, GianMario ^a   D'Agostino, Claudia ^a   Di Bari, Michele Angelo ^a   Chiappini, Barbara ^a   Conte, Michela ^a   Rosone, Francesca ^b   De Grossi, Luigi ^b   Scavia, Gaia ^a   Agrimi, Umberto ^a   Nonno, Romolo ^a   Vaccari, Gabriele ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE REGIONI LAZIO E TOSCANA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL STUDY; GENE AMPLIFICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INFECTION SENSITIVITY; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MISFOLDING CYCLIC AMPLIFICATION; SCRAPIE; SHEEP; VIRUS ISOLATION; VIRUS RESISTANCE; VIRUS TRANSMISSION;

OVIS ARIES;

EID: 79961182818     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00241-11     Document Type: Article

References (51)

1. Acutis, P. L., et al. 2004. Low frequency of the scrapie resistance-associated allele and presence of lysine-171 allele of the prion protein gene in Italian Biellese ovine breed. J. Gen. Virol. 85:3165-3172.
2. Andréoletti, O., et al. 2004. PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat. Med. 10:591-593.
3. Baylis, M., et al. 2004. Risk of scrapie in British sheep of different prion protein genotype. J. Gen. Virol. 85:2735-2740.
4. Baylis, M., and W. Goldmann. 2004. The genetics of scrapie in sheep and goats. Curr. Mol. Med. 4:385-396.
5. Belt, P. B., et al. 1995. Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. J. Gen. Virol. 76(3):509-517.
6. Benestad, S. L., J. N. Arsac, W. Goldmann, and M. Noremark. 2008. Atypical/ Nor98 scrapie: properties of the agent, genetics, and epidemiology. Vet. Res. 39:19.
7. Bossers, A., R. de Vries, and M. A. Smits. 2000. Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP. J. Virol. 74:1407-1414.
8. Bossers, A., B. E. Schreuder, I. H. Muileman, P. B. Belt, and M. A. Smits. 1996. PrP genotype contributes to determining survival times of sheep with natural scrapie. J. Gen. Virol. 77(10):2669-2673.
9. Bruce, M. E. 1993. Scrapie strain variation and mutation. Br. Med. Bull. 49:822-838.
10. Castilla, J., et al. 2008. Cell-free propagation of prion strains. EMBO J. 27:2557-2566.
11. Castilla, J., P. Saa, C. Hetz, and C. Soto. 2005. In vitro generation of infectious scrapie prions. Cell 121:195-206.
12. Castilla, J., P. Saa, and C. Soto. 2005. Detection of prions in blood. Nat. Med. 11:982-985.
13. Di Bari, M. A., et al. 2008. The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie. J. Gen. Virol. 89:2975-2985.
14. Dickinson, A. G., and H. Fraser. 1979. An assessment of the genetics of scrapie in sheep and mice, p. 367-385. In S. B. Prusiner and W. J. Hadlow (ed.), Slow transmissible diseases of the nervous system, vol. 1. Academic Press, New York, NY.
15. Eloit, M., et al. 2005. BSE agent signatures in a goat. Vet. Rec. 156:523-524.
16. Elsen, J. M., et al. 1999. Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch. Virol. 144:431-445.
17. Fernàndez-Borges, N., J. de Castro, and J. Castilla. 2009. In vitro studies of the transmission barrier. Prion 3:220-223.
18. Goldmann, W., et al. 2006. Ovine prion protein variant A136R154L168Q171 increases resistance to experimental challenge with bovine spongiform encephalopathy agent. J. Gen. Virol. 87:3741-3745.
19. Goldmann, W., et al. 1990. Two alleles of a neural protein gene linked to scrapie in sheep. Proc. Natl. Acad. Sci. U. S. A. 87:2476-2480.
20. Goldmann, W., N. Hunter, G. Smith, J. Foster, and J. Hope. 1994. PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J. Gen. Virol. 75(5):989-995.
21. Gonzalez-Romero, D., M. A. Barria, P. Leon, R. Morales, and C. Soto. 2008. Detection of infectious prions in urine. FEBS Lett. 582:3161-3166.
22. Groschup, M. H., et al. 2007. Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France. Emerg. Infect. Dis. 13:1201-1207.
23. Haley, N. J., D. M. Seelig, M. D. Zabel, G. C. Telling, and E. A. Hoover. 2009. Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay. PLoS One 4:e4848.
24. Hunter, N. 1997. PrP genetics in sheep and the applications for scrapie and BSE. Trends Microbiol. 5:331-334.
25. Ikeda, T., et al. 1995. Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan. J. Gen. Virol. 76(10):2577-2581.
26. Jeffrey, M., et al. 2006. Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies. J. Comp. Pathol. 134:171-181.
27. Jones, M., et al. 2007. In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc. J. Pathol. 213:21-26.
28. Kocisko, D. A., et al. 1994. Cell-free formation of protease-resistant prion protein. Nature 370:471-474.
29. Kurt, T. D., et al. 2007. Efficient in vitro amplification of chronic wasting disease PrPRES. J. Virol. 81:9605-9608.
30. Langeveld, J. P., et al. 2006. Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep. BMC Vet. Res. 2:19.
31. Laplanche, J. L., et al. 1993. PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. Genomics 15:30-37.
32. Ligios, C., et al. 2007. Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. PLoS One 2:e859.
33. Ligios, C., et al. 2005. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat. Med. 11:1137-1138.
34. Maddison, B. C., et al. 2010. Prions are secreted into the oral cavity in sheep with preclinical scrapie. J. Infect. Dis. 201:1672-1676.
35. Moum, T., et al. 2005. Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases. J. Gen. Virol. 86:231-235.
36. Oesch, B., et al. 1985. A cellular gene encodes scrapie PrP 27-30 protein. Cell 40:735-746.
37. Perrier, V., et al. 2002. Dominant-negative inhibition of prion replication in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 99:13079-13084.
38. Piening, N., et al. 2006. Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo. J. Biol. Chem. 281:9373-9384.
39. Raymond, G. J., et al. 1997. Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature 388:285-288.
40. Rubenstein, R., et al. 2010. A novel method for preclinical detection of PrPSc in blood. J. Gen. Virol. 91:1883-1892.
41. Saborio, G. P., B. Permanne, and C. Soto. 2001. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411:810-813.
42. Siso, S., et al. 2006. Prion protein in kidneys of scrapie-infected sheep. Vet. Rec. 159:327-328.
43. Tattum, M. H., S. Jones, S. Pal, J. Collinge, and G. S. Jackson. 2010. Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification. Transfusion 50:996-1002.
44. Thorne, L., and L. A. Terry. 2008. In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie. J. Gen. Virol. 89:3177-3184.
45. Tranulis, M. A., A. Osland, B. Bratberg, and M. J. Ulvund. 1999. Prion protein gene polymorphisms in sheep with natural scrapie and healthy controls in Norway. J. Gen. Virol. 80(4):1073-1077.
46. Tsunoda, K., et al. 2010. Prion protein polymorphisms and estimation of risk of scrapie in East Asian sheep. Biochem. Genet. 48:13-25.
47. Vaccari, G., et al. 2007. Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy. J. Virol. 81:7306-7309.
48. Vaccari, G., et al. 2009. State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology. Vet. Res. 40:48.
49. Vaccari, G., et al. 2001. PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report. Arch. Virol. 146:2029-2037.
50. Vaccari, G., et al. 2009. Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep. Vet. Res. 40:19.
51. Vascellari, M., et al. 2007. PrPSc in salivary glands of scrapie-affected sheep. J. Virol. 81:4872-4876.