In vitro amplification of prions from milk in the detection of subclinical infections

Prion

Volumn 3, Issue 4, 2009, Pages

  Gough, Kevin C ^a   Baker, Claire A ^b   Taema, Maged ^a   Maddison, Ben C ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

BSE; Milk; Prion; PrP; Scrapie

Indexed keywords

PRION PROTEIN;

BOVINE SPONGIFORM ENCEPHALOPATHY; CONFERENCE PAPER; GENE AMPLIFICATION; GENOTYPE; HUMAN; MILK; NONHUMAN; PRION DISEASE; SCRAPIE AGENT; ANIMAL; ARTICLE; CATTLE; METABOLISM; PRION; PROTEIN FOLDING;

ANIMALIA; BOVINAE; OVIS; OVIS ARIES;

ANIMALS; CATTLE; ENCEPHALOPATHY, BOVINE SPONGIFORM; MILK; PRIONS; PROTEIN FOLDING;

EID: 74249102049     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.3.4.10425     Document Type: Conference Paper

References (30)

1. Maddison BC, Baker C, Rees HC, Terry LA, Thorne L, Bellworthy SJ, et al. Scrapie prions are secreted in ovine milk from clinically normal scrapie-exposed animals. J Virol 2009; 83:15-8.
2. Saá P, Castilla J, Soto C. Presymptomatic detection of prions in blood. Science 2006; 313:92-4.
3. Saborio GP, Permanne B, Soto C. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 2001; 411:810-3.
4. Sc. J Pathol 2007; 213:21-6.
5. RES. J Virol 2007; 81:9605-8.
6. Sc derived from the brain and blood of sheep infected with scrapie. J Gen Virol 2008; 89:3177-84.
7. Tongue SC, Pfeiffer DU, Warner R, Elliot H, Del Rio Vilas V. Estimation of the relative risk of developing clinical scrapie: the role of prion protein (PrP) genotype and selection bias. Vet Rec 2006; 158:43-50.
8. Hill AF, Joiner S, Linehan J, Debruslais M, Lantos PL, Collinge J. Species barrier independent prion replication in apparently resistant species. Proc Natl Acad Sci USA 2000; 97:10248-53.
9. Thorgeirsdottir S, Georegsson G, Reynisson E, Sigurdarson S, Palsdottir E. Search for healthy carriers of scrapie: an assessment of subclinical infection of sheep in an Icelandic scrapie flock by three diagnostic methods and correlation with PrP genotypes. Arch Virol 2002; 147:709-22.
10. Georgsson G, Adolfsdottir JA, Palsdottir A, Jorundsson E, Sigurdarson S, Thorgeirsdotir S. High incidence of subclinical infection of lymphoid tissues in scrapie-affected sheep flocks. Arch Virol 2008; 153:637-44.
11. Sc) in nervous and lymphoid tissues of sheep with subclinical scrapie. Vet Pathol 2003; 40:164-74.
12. Sc detection and its use as a rapid surveillance method for the diagnosis of bovine spongiform encephalopathy (BSE). Acta Neuropathol 1999; 98:437-43.
13. Espinosa JC, Morales M, Castilla J, Rogers M, Torres JM. Progression of prion infectivity in asymptomatic cattle after oral bovine spongiform encephalopathy challenge. J Gen Virol 2007; 88:1379-83.
14. Race R, Raines A, Raymond GJ, Caughey B, Chesebro B. Long-term subclinical carrier state procedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans. J Virol 2001; 75:10106-12.
15. Thackray AM, Klein MA, Aguzzi A, Budjoso R. Chronic subclinical prion disease induced by lowdose inoculum. J Virol 2002; 76:2510-7.
16. Thackray AM, Klein MA, Budjoso R. Subclinical prion disease induced by oral inoculation. J Virol 2003; 77:7991-8.
17. Collins SJ, Lewis V, Brazier MW, Hill AF, Lawson VA, Klug GM, Masters CL. Extended periods of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control. Neurobiol Dis 2005; 20:336-46.
18. Baier M, Norley S, Schultz J, Burwinkel M, Schwarz A, Riemer C. Prion diseases: infectious and lethal doses following oral challenge. J Gen Virol 2003; 84:1927-9.
19. Asante EA, Linehan JM, Gowland I, Joiner S, Fox K, Cooper S, et al. Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein 129 heterozygous mice. Proc Natl Acad Sci USA 2006; 103:10759-64.
20. Asante EA, Linehan JM, Desbruslais M, Joiner S, Gowland I, Wood AL, et al. BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. EMBO J 2002; 21:6358-66.
21. Castilla J, Saá P, Soto C. Detection of prions in blood. Nature Med 2005; 11:982-5.
22. Langeveld JPM, Jacobs JG, Erkens JHF, Bossers A, van Zijderveld FG, van Keulen LJM. Rapid and discriminatory diagnosis of scrapie and BSE in retropharyngeal lymph nodes of sheep. BMC Vet Res 2006; 2:19.
23. Soto C, Anderes L, Suardi S, Cardone F, Castilla J, Frossard M-J, et al. Pre-symptomatic detection of prions by cyclic amplification of protein misfolding. FEBS Letts 2005; 579:638-42.
24. Foster JD, Parnham D, Chong A, Goldmann W, Hunter N. Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats. Vet Rec 2001; 148:165-71.
25. Goldmann W, Hunter N, Smith G, Foster J, Hope J. PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol 1994; 75:989-95.
26. Diringer H, Roehmel J, Beekes M. Effect of repeated oral infection of hamsters with scrapie. J Gen Virol 1998; 79:609-12.
27. Gravenor MB, Stallard N, Curnow R, McLean AR. Repeated challenge with prion disease: the risk of infection and impact on incubation period. Proc Natl Acad Sci USA 2003; 100:10960-5.
28. Jacguemot C, Cuche C, Dormont D, Lazarini F. High incidence of scrapie induced by repeated injections of subinfectious prion doses. J Virol 2005; 79:8904-8.
29. Castilla J, Brun A, Segundo FD-S, Salguero FJ, Gutiérrez- Adán A, Pintado B, et al. Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model. J Virol 2005; 79:8665-8.
30. Wilesmith JW, Ryan JMB. Absence of BSE in the offspring of pedigree suckler cows affected by BSE in Great Britain. Vet Rec 1997; 141:250-1.