A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells

Microbiology and Immunology

Volumn 54, Issue 2, 2010, Pages 112-121

  Shimizu, Yoshihisa ^a   Kaku Ushiki, Yuko ^b   Iwamaru, Yoshifumi ^a   Muramoto, Tamaki ^c   Kitamoto, Tetsuyuki ^c   Yokoyama, Takashi ^a   Mohri, Shirou ^a   Tagawa, Yuichi ^a  

^a NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

^b NIPPI RESEARCH INSTITUTE OF BIOMATRIX   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anti prion effect; Monoclonal antibody; Single chain fragment variable region

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; PRION PROTEIN MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CATTLE; CELL SURFACE; CROSS REACTION; DEER; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLYCOSYLATION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRION DISEASE; SCRAPIE; SCREENING; SHEEP; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CATTLE DISEASES; CELL LINE; CELLS, CULTURED; CRICETINAE; DEER; MICE; PRION DISEASES; PRIONS; SHEEP; SHEEP DISEASES; SINGLE-CHAIN ANTIBODIES;

BOS; CERVIDAE; EUKARYOTA; MUS; OVIS ARIES;

EID: 76649106715     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2009.00190.x     Document Type: Article

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