The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Martinez Abundis, Eduardo ^a   Rajapurohitam, Venkatesh ^a   Haist, James V ^a   Gan, Xiaohong T ^a   Karmazyn, Morris ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCEIN; CALCIUM CHLORIDE; CASPASE 3; DIGITONIN; LEPTIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SANGLIFEHRIN A; STAT1 PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HEART MITOCHONDRION; HYPERTROPHY; INTRACELLULAR SIGNALING; MITOCHONDRIAL PERMEABILITY; NEWBORN; NICK END LABELING; NONHUMAN; OBESITY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SENSITIZATION;

ANIMALS; APOPTOSIS; CALCIUM; DIGITONIN; HYPERTROPHY; LEPTIN; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCYTES, CARDIAC; OBESITY; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS;

RATTUS;

EID: 84864341714     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041612     Document Type: Article

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