Molecular dynamics simulation of the SH3 domain aggregation suggests a generic amyloidogenesis mechanism

Journal of Molecular Biology

Volumn 324, Issue 4, 2002, Pages 851-857

  Ding, Feng ^a   Dokholyan, Nikolay V ^b,c   Buldyrev, Sergey V ^a   Stanley, H Eugene ^a   Shakhnovich, Eugene I ^b  

^a Boston University   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aggregation; Amyloid fibril; Amyloidogenesis; Dimerization; Discrete molecular dynamics

Indexed keywords

AMINO ACID; AMYLOID; DIMER; M PROTEIN;

AMYLOIDOSIS; ARTICLE; BETA SHEET; CHEMICAL INTERACTION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; SIMULATION;

EID: 0036923039     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01112-9     Document Type: Article

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