Genome-wide identification of palmitate-regulated immediate early genes and target genes in pancreatic beta-cells reveals a central role of NF-κB

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 6781-6789

  Choi, Hyung Jin ^a   Hwang, Seungwoo ^b   Lee, Se Hee ^a   Lee, You Ri ^a   Shin, Jiyon ^a   Park, Kyong Soo ^a   Cho, Young Min ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Fatty acids, Nonesterified; Genes, Immediate early; Insulin secreting cells; NF kappa B; Oligonucleotide array sequence analysis; Palmitates

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE IDENTIFICATION; HEPATOCYTE GROWTH FACTOR GENE; IMMEDIATE EARLY GENE; IN VITRO STUDY; INHIBIN BETA B GENE; INTERLEUKIN 1 RECEPTOR LIKE 1 GENE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEAR FACTOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELL 1 GENE; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TRANSFERRIN RECEPTOR GENE;

ANIMALS; BINDING SITES; CELLS, CULTURED; CYCLOHEXIMIDE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENES, IMMEDIATE-EARLY; GENOME; INSULIN-SECRETING CELLS; MICE; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PALMITATES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN INTERACTION MAPS;

EID: 84864282681     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1503-5     Document Type: Article

References (34)

1. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444(7121):840-846. doi:10.1038/nature05482 (Pubitemid 46024990)
2. Schenk S, Saberi M, Olefsky JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118(9):2992-3002. doi:10.1172/JCI34260
3. Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P (2002) Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51(5):1437-1442 (Pubitemid 34826609)
4. Piro S, Anello M, Di Pietro C, Lizzio MN, Patane G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F (2002) Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 51(10): 1340-1347 (Pubitemid 35174157)
5. Cnop M (2008) Fatty acids and glucolipotoxicity in the patho-genesis of type 2 diabetes. Biochem Soc Trans 36(Pt 3):348-352. doi:10.1042/BST0360348 (Pubitemid 351839329)
6. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E (1995) A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38(10):1213-1217
7. Boni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY (2009) Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology 150(12):5218-5229. doi:10.1210/en.2009- 0543
8. Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V (2003) Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 278(32):30015-30021. doi:10.1074/jbc.M302548 200M302548200pii (Pubitemid 36962391)
9. Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ (2007) Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50(4):752-763. doi:10.1007/s00125-006-0590-z (Pubitemid 46355827)
10. Bikopoulos G, da Silva Pimenta A, Lee SC, Lakey JR, Der SD, Chan CB, Ceddia RB, Wheeler MB, Rozakis-Adcock M (2008) Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids. J Endocrinol 196(3):455-464. doi:196/3/455pii10.1677/JOE-07-0174 (Pubitemid 351425501)
11. Busch AK, Cordery D, Denyer GS, Biden TJ (2002) Expression profiling of palmitate-and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function. Diabetes 51(4):977-987 (Pubitemid 34438339)
12. Glauser DA, Brun T, Gauthier BR, Schlegel W (2007) Transcrip-tional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes. BMC Mol Biol 8:54. doi:10.1186/1471-2199-8-54 (Pubitemid 47225316)
13. Bourdeau V, Deschenes J, Laperriere D, Aid M, White JH, Mader S (2008) Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells. Nucleic Acids Res 36(1):76-93. doi:gkm945pii10.1093/nar/gkm945
14. Newton R, Adcock IM, Barnes PJ (1996) Superinduction of NF-kappa B by actinomycin D and cycloheximide in epithelial cells. Biochem Biophys Res Commun 218(2):518-523. doi:10.1006/bbrc.1996.0093 (Pubitemid 26040778)
15. Faggioli L, Costanzo C, Merola M, Furia A, Palmieri M (1997) Protein synthesis inhibitors cycloheximide and anisomycin induce interleukin-6 gene expression and activate transcription factor NF-kappaB. Biochem Biophys Res Commun 233(2): 507-513. doi:10.1006/bbrc.1997.6489 (Pubitemid 27226658)
16. Aerts S, Van Loo P, Thijs G, Mayer H, de Martin R, Moreau Y, De Moor B (2005) TOUCAN 2: the all-inclusive open source workbench for regulatory sequence analysis. Nucleic Acids Res 33 (Web Server issue):W393-396. doi:10.1093/nar/gki354 (Pubitemid 44529950)
17. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA (2003) DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4(5):P3
18. Brown KR, Jurisica I (2007) Unequal evolutionary conservation of human protein interactions in interologous networks. Genome Biol 8(5):R95. doi:10.1186/gb-2007-8-5-r95 (Pubitemid 351895134)
19. Donath MY, Boni-Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA (2010) Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endo-crinol Metab 21(5):261-267. doi:10.1016/j.tem.2009.12.010
20. Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL (2004) Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145(11):5087-5096. doi:10.1210/en.2004-0478 (Pubitemid 39551129)
21. Sweet MJ, Leung BP, Kang D, Sogaard M, Schulz K, Trajkovic V, Campbell CC, Xu D, Liew FY (2001) A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol 166(11):6633-6639 (Pubitemid 32467204)
22. Mensah-Brown E, Shahin A, Parekh K, Hakim AA, Shamisi MA, Hsu DK, Lukic ML (2006) Functional capacity of macrophages determines the induction of type 1 diabetes. Ann N Y Acad Sci 1084:49-57. doi:10.1196/annals.1372.014 (Pubitemid 47091948)
23. Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Ve-lazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocana A (2011) Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes 60(2):525-536. doi:10.2337/db09-1305
24. Santangelo C, Matarrese P, Masella R, Di Carlo MC, Di Lillo A, Scazzocchio B, Vecci E, Malorni W, Perfetti R, Anastasi E (2007) Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxi-dative stress. J Mol Endocrinol 38(1-2):147-158. doi:10.1677/jme.1.02133 (Pubitemid 46351600)
25. Bertolino P, Holmberg R, Reissmann E, Andersson O, Berggren PO, Ibanez CF (2008) Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci USA 105(20):7246-7251. doi:10.1073/pnas.0801285105 (Pubitemid 351754463)
26. Fernandez-Real JM, Mercader JM, Ortega FJ, Moreno-Navarrete JM, Lopez-Romero P, Ricart W (2010) Transferrin receptor-1 gene polymorphisms are associated with type 2 diabetes. Eur J Clin Invest 40(7):600-607. doi:10.1111/j.1365-2362.2010.02306.x
27. Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL (2001) Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes 50(5):909-920 (Pubitemid 32374519)
28. Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhoffer M, Orntoft T, Eizirik DL (2001) A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-depen-dent genes in primary rat pancreatic beta-cells. J Biol Chem 276(52):48879-48886. doi:10.1074/jbc.M108658200
29. Chillambhi S, Turan S, Hwang DY, Chen HC, Juppner H, Ba-stepe M (2010) Deletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cis. J Clin Endocrinol Metab 95(8):3993-4002. doi:10.1210/jc.2009-2205
30. Frohlich LF, Mrakovcic M, Steinborn R, Chung UI, Bastepe M, Juppner H (2010) Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib. Proc Natl Acad Sci USA 107(20):9275-9280. doi:10.1073/pnas.0910224107
31. Conlin A, Kaltenbach T, Kusano C, Matsuda T, Oda I, Gotoda T (2010) Endoscopic resection of gastrointestinal lesions: advancement in the application of endoscopic submucosal dissection. J Gastroenterol Hepatol 25(8):1348-1357. doi:10.1111/j.1440-1746.2010.06402.x
32. Parks WC, Wilson CL, Lopez-Boado YS (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 4(8):617-629. doi:10.1038/nri1418 nri1418pii (Pubitemid 39025047)
33. Wolf M, Albrecht S, Marki C (2008) Proteolytic processing of chemokines: implications in physiological and pathological conditions. Int J Biochem Cell Biol 40(6-7):1185-1198. doi: 10.1016/j.biocel.2007.12.009
34. Roche E, Buteau J, Aniento I, Reig JA, Soria B, Prentki M (1999) Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1. Diabetes 48(10):2007-2014 (Pubitemid 29458364)