Association between MTHFR C677T polymorphism and osteonecrosis of the femoral head: A meta-analysis

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 7089-7094

  Shang, Xi Fu ^a   Su, Hong ^b   Chang, Wei Wei ^b   Wang, Chen Cheng ^c   Han, Qin ^b   Xu, Zhi Wei ^b  

^a ANHUI PROVINCIAL HOSPITAL   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c WANNAN MEDICAL COLLEGE   (China)

Author keywords

Meta analysis; MTHFR; Osteonecrosis; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ARTICLE; DISEASE PREDISPOSITION; EFFECT SIZE; ETHNICITY; FEMUR HEAD NECROSIS; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HOMOZYGOSITY; HUMAN; MTHFR GENE; PATHOGENESIS; RACE DIFFERENCE; RISK ASSESSMENT; SYSTEMATIC REVIEW;

ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; FEMUR HEAD NECROSIS; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBLICATIONS; RISK FACTORS;

TETRA;

EID: 84864279337     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1540-0     Document Type: Article

References (30)

1. Asano T, Takahashi KA, Fujioka M et al (2004) Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrino-lytic systems in Japanese subjects. Transplantation 77:220-225 (Pubitemid 38155750)
2. Bernbeck B, Mauz-Körholz C, Zotz RB (2003) Methylenete- trahydrofolate reductase generphism and glucocorticoid intake in children with all and aseptic osteonecrosis. Klin Padiatr 215(6): 327-331 (Pubitemid 38064631)
3. Bjorkman A, Svensson PJ, Hillarp A et al (2004) Factor V Leiden and prothrombin gene mutation: risk factors for osteonecrosis of the femoral head in adults. Clin Orthop Relat Res 425:168-172 (Pubitemid 39062765)
4. Bjorkman A, Burtscher IM, Svensson PJ et al (2005) Factor V Leiden and the prothrombin 20210A gene mutation and osteo-necrosis of the knee. Arch Orthop Trauma Surg 125:51-55 (Pubitemid 40305469)
5. Celik A, Tekis D, Saglam F et al (2006) Association of cortico-steroids and factor V, prothrombin, and MTHFR gene mutations with avascular osteonecrosis in renal allograft recipients. Transplant Proc 38(2):512-516
6. Chang JD, Hur M, Lee SS et al (2008) Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population. Clin Orthop Relat Res 466:1041-1046
7. Egger M, Davey SG, Schneider M et al (1997) Bias in meta-anal-ysis detected by a simple, graphical test. Br Med J 315:629-634 (Pubitemid 27387172)
8. Frosst P, Blom HJ, Milos R et al (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenete-trahydrofolate reductase. Nat Genet 10:111
9. Glueck CJ, Fontaine RN, Gruppo R et al (1999) The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin Orthop Relat Res 366:133-146 (Pubitemid 29439347)
10. Glueck CJ, Freiberg RA, Fontaine RN et al (2001) Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res 386:19-33 (Pubitemid 32391273)
11. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558 (Pubitemid 34746062)
12. Kang SS, Passen EL, Ruggie N et al (1993) Thermolabile defect of Methylenetetrahydrofolate reductase in coronary artery disease. Circulation 88:1463
13. Kim JM, Stewart R, Kim SW et al (2008) Methylenetetrahy-drofolate reductase gene and risk of Alzheimer's disease in Koreans. Int J Geriatr Psychiatry 23:454-459 (Pubitemid 351722103)
14. Kim TH, Hong JM, Kim HJ et al (2010) Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population. Mol Cells 29:343-348
15. Kutlar A, Kutlar F, Turker I et al (2001) The methylene tetra-hydrofolate reductase R (C677T) mutation as a potential risk factor for avascular necrosis in sickle cell disease. Hemoglobin 25:213-217 (Pubitemid 32660541)
16. Lentz SR, Piegors DJ, Fernandez JA et al (2002) Effect of hyperhomocysteinemia on protein C activation and activity. Blood 100:2108-2112 (Pubitemid 35001245)
17. Liu BL, Li ZR, Sun W et al (2009) Relationship between alcohol induced osteonecrosis of femoral head and single nucleotide polymorphisms of methylene tetrahydrofolate reductase 677 C/T. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1079-1082 Chinese
18. Morita H, Taguchi J, Kurihara H et al (1997) Genetic polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 95:2032
19. Morita H, Kurihara H, Tsubaki S et al (1998) Methylenete-trahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscler Thromb Vasc Biol 18:1465
20. Petitti DB (1994) Meta-analysis, decision analysis, and cost-effectiveness analysis. Oxford University Press, New York
21. Rosenberg N, Murata M, Ikeda Y et al (2002) The frequent 5, 10-methylenetetrahydrofolate reductase C677T polymorphisms associated with a common haplotype in whites, Japanese, and Africans. Am J Hum Genet 70:758-762 (Pubitemid 34177929)
22. Sadewa AH, Sutomo RS, Hayashi C et al (2002) The C677T mutation in the methylenetetrahydrofolate reductase gene among the Indonesian Javanese population. Kobe J Med Sci 48:137-144 (Pubitemid 36693093)
23. Tsai JC, Wang H, Perrella MA et al (1996) Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest 97:146
24. Ueland PM, Hustad S, Schneede J et al (2001) Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22:195-201 (Pubitemid 32244306)
25. Wacholder S, McLaughlin JK, Silverman DT et al (1992) Selection of controls in case-control studies: I. Principles. Am J Epidemiol 135:1019-1028
26. Weisberg I, Tran P, Christensen B et al (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169-172 (Pubitemid 28453294)
27. Wermes C, Bergmann F, Reller B et al (1999) Severe protein C deficiency and aseptic osteonecrosis of the hip joint: a case report. Eur J Pediatr 158:S159-S161 (Pubitemid 30014026)
28. Zalavras CG, Vartholomatos G, Dokou E et al (2002) Factor V Leiden and prothrombin gene mutations in femoral head osteo-necrosis. Thromb Haemost 87:1079-1080 (Pubitemid 34624896)
29. Zalavras CG, Malizos KN, Dokou E et al (2002) The 677C ? T mutation of the methylenetetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head. Haematolog-ica 87:111-112 (Pubitemid 34101122)
30. Zalavras CG, Vartholomatos G, Dokou E et al (2004) Genetic background of osteonecrosis: associated with thrombophilic mutations? Clin Orthop Relat Res 422:251-255 (Pubitemid 38685501)