The methylene tetrahydrofolate reductase (C677T) mutation as a potential risk factor for avascular necrosis in sickle cell disease

Hemoglobin

Volumn 25, Issue 2, 2001, Pages 213-217

  Kutlar, A ^a   Kutlar, F ^a   Turker, I ^a   Tural, C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADOLESCENT; ADULT; AVASCULAR NECROSIS; CONFERENCE PAPER; FEMALE; FEMUR HEAD; GENE MUTATION; HUMAN; HUMERUS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; RISK FACTOR; SICKLE CELL ANEMIA;

ADOLESCENT; ADULT; ALPHA-THALASSEMIA; ANEMIA, SICKLE CELL; FEMALE; GENE FREQUENCY; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OSTEONECROSIS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POINT MUTATION; RISK FACTORS;

EID: 0034944343     PISSN: 03630269     EISSN: None     Source Type: Journal    
DOI: 10.1081/HEM-100104029     Document Type: Conference Paper

References (14)

1. Modulation of the phenotypic diversity of sickle cell anemia
2. Sickle cell disease as a cause of osteonecrosis of the femoral head
3. The prevalence of avascular necrosis in sickle cell anemia: Correlation with α-thalassemia
4. Prothrombin mutant, factor V leiden, and thermolabile variant of methylenetetrahydrofolate reductase among patients with sickle cell disease in Brazil
5. The methylenetetrahydrofolate reductase gene C677T polymorphism in patients with homozygous sickle cell disease and stroke
6. 5,10-Methylenetetrhaydrofolate reductase C677T mutation and stroke in sickle cell
7. Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease
8. Frequency of a common thermolabile MTHFR (5,10-methylene tetrahydrofo]ate reductase) mutant among patients with sickle cell disease
9. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
10. Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: Evidence for an important genetic-environmental interaction
11. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease
12. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia
13. Construction of human gene libraries from small amounts of peripheral blood: Analysis of β-like globin genes
14. Frequency of the 677 C → T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients: Association with Osteonecrosis