Factor V Leiden and prothrombin gene mutations in femoral head osteonecrosis

Thrombosis and Haemostasis

Volumn 87, Issue 6, 2002, Pages 1079-1080

  Zalavras, Charalampos G ^a   Vartholomatos, George ^a   Dokou, Elini ^a   Malizos, Konstantinos N ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN; STEROID; BLOOD CLOTTING FACTOR 5;

ADULT; ALCOHOLISM; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMUR HEAD NECROSIS; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; IDIOPATHIC DISEASE; LETTER; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SICKLE CELL ANEMIA; STATISTICAL SIGNIFICANCE; SYSTEMIC LUPUS ERYTHEMATOSUS; BONE NECROSIS; CASE CONTROL STUDY; FEMUR; GENETICS; MUTATION; PATHOLOGY; THROMBOPHILIA;

CASE-CONTROL STUDIES; FACTOR V; FEMUR; HUMANS; MUTATION; OSTEONECROSIS; PROTHROMBIN; THROMBOPHILIA;

EID: 0036282612     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613138     Document Type: Letter

References (13)

1. Risk factors potentially activating intravascular coagulation and causing nontraumatic osteonecrosis
2. Thrombophilia as a multigenic disease
3. Hypercoagulability and osteonecrosis
4. The plasminogen activator inhibitor-1 gene, hypofibrinolysis and osteonecrosis
5. Hypofibrinolysis, thrombophilia, osteonecrosis
6. Epidemiology of factor V Leiden: Clinical implications
7. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C
8. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
9. Thrombophilia and hypofibrinolysis. Pathophysiologies of osteonecrosis
10. Potential aetiological factors concerning the development of osteonecrosis of the femoral head
11. A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis
12. Multicenter experience with free vascularized fibular grafts for osteonecrosis of the femoral head
13. Treatment of avascular necrosis of the femoral head with vascularized fibular transplant