Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Porritt, Michelle J ^a   Andersson, Helene C ^a   Hou, Linda ^a   Nilsson, Åsa ^b   Pekna, Marcela ^a   Pekny, Milos ^a   Nilsson, Michael ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE A4; HEME OXYGENASE 1; PLACEBO; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL ACTIVITY; CELL COUNT; CELL PROLIFERATION; DRUG EFFICACY; GLIA CELL; MALE; MOTOR PERFORMANCE; MOUSE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PHOTOTHROMBOSIS; PHYSICAL ACTIVITY; SINGLE DRUG DOSE; TISSUE INJURY; TRANSCRIPTION INITIATION; TREATMENT DURATION; TREATMENT RESPONSE; WALKING;

ANIMALS; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLIOSIS; MALE; MICE; MOTOR ACTIVITY; NAD(P)H DEHYDROGENASE (QUINONE); NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; RNA, MESSENGER; THIOCYANATES;

EID: 84864275231     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041090     Document Type: Article

References (43)

1. Stankowski JN, Gupta R, (2011) Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation? Antioxid Redox Signal 14: 1841-1851.
2. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, et al. (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359: 1317-1329.
3. van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, et al. (2010) Can animal models of disease reliably inform human studies? PLoS Med 7: e1000245.
4. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, et al. (2009) Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40: 2244-2250.
5. Dinkova-Kostova AT, Talalay P, (2010) NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys 501: 116-123.
6. Lu SC, (2009) Regulation of glutathione synthesis. Mol Aspects Med 30: 42-59.
7. So HS, Kim HJ, Lee JH, Lee JH, Park SY, et al. (2006) Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin. Cell Death Differ 13: 1763-1775.
8. Crack PJ, Taylor JM, de Haan JB, Kola I, Hertzog P, et al. (2003) Glutathione peroxidase-1 contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic mouse in response to ischemia/reperfusion injury. J Cereb Blood Flow Metab 23: 19-22.
9. Hoehn B, Yenari MA, Sapolsky RM, Steinberg GK, (2003) Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke. Stroke 34: 2489-2494.
10. Shah ZA, Nada SE, Dore S, (2011) Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection. Neuroscience 180: 248-255.
11. Yu SS, Zhao J, Lei SP, Lin XM, Wang LL, et al. (2011) 4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action. Neurochem Res 36: 339-346.
12. Mattson MP, (2008) Awareness of hormesis will enhance future research in basic and applied neuroscience. Crit Rev Toxicol 38: 633-639.
13. Zhao J, Moore AN, Clifton GL, Dash PK, (2005) Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury. J Neurosci Res 82: 499-506.
14. Zhao J, Kobori N, Aronowski J, Dash PK, (2006) Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393: 108-112.
15. Chen G, Fang Q, Zhang J, Zhou D, Wang Z, (2011) Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J Neurosci Res 89: 515-523.
16. Bergstrom P, Andersson HC, Gao Y, Karlsson JO, Nodin C, et al. (2011) Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage. Neuropharmacology 60: 343-353.
17. Son TG, Camandola S, Arumugam TV, Cutler RG, Telljohann RS, et al. (2009) Plumbagin, a Novel Nrf2/ARE Activator, Protects Against Cerebral Ischemia. J Neurochem.
18. Zhao X, Sun G, Zhang J, Strong R, Dash PK, et al. (2007) Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke 38: 3280-3286.
19. Ping Z, Liu W, Kang Z, Cai J, Wang Q, et al. (2010) Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme. Brain Res 1343: 178-185.
20. Demougeot C, Bertrand N, Prigent-Tessier A, Garnier P, Mossiat C, et al. (2003) Reversible loss of N-acetyl-aspartate in rats subjected to long-term focal cerebral ischemia. J Cereb Blood Flow Metab 23: 482-489.
21. Grome JJ, Gojowczyk G, Hofmann W, Graham DI, (1988) Quantitation of photochemically induced focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 8: 89-95.
22. Lee JK, Park MS, Kim YS, Moon KS, Joo SP, et al. (2007) Photochemically induced cerebral ischemia in a mouse model. Surg Neurol 67: 620-625; discussion 625.
23. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD, (1985) Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol 17: 497-504.
24. Paxinos G, Watson C, (2007) The rat brain in stereotaxic coordinates. London: Elsevier Inc.
25. Schallert T, (2006) Behavioral tests for preclinical intervention assessment. NeuroRx 3: 497-504.
26. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST, (2000) CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39: 777-787.
27. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
28. Kernie SG, Erwin TM, Parada LF, (2001) Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice. J Neurosci Res 66: 317-326.
29. Nioi P, Hayes JD, (2004) Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res 555: 149-171.
30. Talalay P, Dinkova-Kostova AT, (2004) Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates. Methods Enzymol 382: 355-364.
31. Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, et al. (2005) Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci U S A 102: 244-249.
32. Cullinan SB, Diehl JA, (2004) PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 279: 20108-20117.
33. Kang KW, Choi SH, Kim SG, (2002) Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction. Nitric Oxide 7: 244-253.
34. Haupt C, Witte OW, Frahm C, (2007) Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury. Mol Cell Neurosci 35: 89-99.
35. Nowicka D, Rogozinska K, Aleksy M, Witte OW, Skangiel-Kramska J, (2008) Spatiotemporal dynamics of astroglial and microglial responses after photothrombotic stroke in the rat brain. Acta Neurobiol Exp (Wars) 68: 155-168.
36. Hubbs AF, Benkovic SA, Miller DB, O'Callaghan JP, Battelli L, et al. (2007) Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. Am J Pathol 170: 2068-2076.
37. Kuroda S, Siesjo BK, (1997) Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci 4: 199-212.
38. Jander S, Kraemer M, Schroeter M, Witte OW, Stoll G, (1995) Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J Cereb Blood Flow Metab 15: 42-51.
39. Schroeter M, Jander S, Witte OW, Stoll G, (1994) Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J Neuroimmunol 55: 195-203.
40. Chang YY, Fujimura M, Morita-Fujimura Y, Kim GW, Huang CY, et al. (1999) Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme. Neurosci Lett 277: 61-64.
41. De Ryck M, Keersmaekers R, Duytschaever H, Claes C, Clincke G, et al. (1996) Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. J Pharmacol Exp Ther 279: 748-758.
42. Snape MF, Baldwin HA, Cross AJ, Green AR, (1993) The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat. Neuroscience 53: 837-844.
43. Kharlamov A, Guidotti A, Costa E, Hayes R, Armstrong D, (1993) Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion. J Neurosci 13: 2483-2494.