Neuroprotective effects of an antioxidant in cortical cerebral ischemia: Prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme

Neuroscience Letters

Volumn 277, Issue 1, 1999, Pages 61-64

  Chang, Yung Yee ^a   Fujimura, Miki ^a   Morita Fujimura, Yuiko ^a   Kim, Gyung Whan ^a   Huang, Chiung Ying ^a   Wu, Hsiu Shan ^a   Kawase, Makoto ^a   Copin, Jean Christophe ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apurinic apyrimidinic endonuclease; DNA base excision repair; Free radical scavenger; Photothiombotic cortical cerebral ischemia; Reactive oxygen species

Indexed keywords

21 AMINOSTEROID; ANTIOXIDANT; DNA BASE; FREE RADICAL; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; EXCISION REPAIR; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; CARBON-OXYGEN LYASES; CEREBRAL CORTEX; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; MALE; MICE; MICE, INBRED STRAINS; NEUROPROTECTIVE AGENTS; PREGNATRIENES;

EID: 0032706652     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00799-5     Document Type: Article

References (11)

1. Bennett R.A.O., Wilson D.M. III, Wong D., Demple B. Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway. Proc. Natl. Acad. Sci. USA. 94:1997;7166-7169.
2. Chan P.H. Role of oxidants in ischemic brain damage. Stroke. 27:1996;1124-1129.
3. Demple B., Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63:1994;915-948.
4. Fujimura M., Morita-Fujimura Y., Kawase M., Chan P.H. Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 19:1999;495-501.
5. Hall E.D., McCall J.M., Means E.D. Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage. Adv. Pharmacol. 28:1994;221-268.
6. Kawase M., Fujimura M., Morita-Fujimura Y., Chan P.H. Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats. Implication of the failure of DNA repair in neuronal apoptosis. Stroke. 30:1999;441-449.
7. Loeb L.A., Preston B.D. Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet. 20:1986;201-230.
8. Morita-Fujimura Y., Fujimura M., Kawase M., Chan P.H. Early decrease of apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice. Neuroscience. 93:1999;1465-1473.
9. Ramana C.V., Boldogh I., Izumi T., Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc. Natl. Acad. Sci. USA. 95:1998;5061-5066.
10. Robertson K.A., Hill D.P., Xu Y., Liu L., Van Epps S., Hockenbery D.M., Park J.R., Wilson T.M., Kelley M.R. Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells. Cell Growth Differ. 8:1997;443-449.
11. Watson B.D., Dietrich W.D., Busto R., Wachtel M.S., Ginsberg M.D. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann. Neurol. 17:1985;497-504.