PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: Toward engineering of functional nanomedicines for alzheimer's disease

ACS Nano

Volumn 6, Issue 7, 2012, Pages 5897-5908

  Brambilla, Davide ^a   Verpillot, Romain ^a   Le Droumaguet, Benjamin ^a   Nicolas, Julien ^a   Taverna, Myriam ^a   Kóňa, Juraj ^b   Lettiero, Barbara ^c   Hashemi, S Hossein ^c   De Kimpe, Line ^d   Canovi, Mara ^e   Gobbi, Marco ^e   Nicolas, Valérie ^f   Scheper, Wiep ^d   Moghimi, S Moein ^c   Tvaroška, Igor ^b   Couvreur, Patrick ^a   Andrieux, Karine ^a  

^a UNIV PARIS SUD   (France)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^f IPSIT   (France)

Author keywords

A 1 42; Alzheimer's disease; binding; nanoparticles; polyethylene glycol

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID BETAS; BINDING; CONFORMATIONAL CHANGE; CYANOACRYLATES; IN-SILICO; NANOMEDICINES; NANOPARTICLE SURFACE; PEGYLATED NANOPARTICLE; PEGYLATION; PEPTIDE AGGREGATION; PEPTIDE BINDING; PEPTIDE CONFORMATION; POLY LACTIC ACID; POLYMERIC NANOPARTICLES; SYSTEMIC CIRCULATION; THIOFLAVIN T;

ADSORPTION; BLOOD; CAPILLARY ELECTROPHORESIS; CONFOCAL MICROSCOPY; FLUORESCENCE SPECTROSCOPY; GLYCOPROTEINS; LACTIC ACID; NANOPARTICLES; OLIGOMERS; POLYETHYLENE GLYCOLS;

PEPTIDES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); MACROGOL DERIVATIVE; NANOPARTICLE; PEPTIDE FRAGMENT; THIAZOLE DERIVATIVE; THIOFLAVINE;

ALZHEIMER DISEASE; ARTICLE; BIOENGINEERING; CAPILLARY ELECTROPHORESIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENT ACTIVATION; HUMAN; IN VITRO STUDY; METABOLISM; MOLECULAR DYNAMICS; NANOMEDICINE; NANOTECHNOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; SURFACE PLASMON RESONANCE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BIOENGINEERING; COMPLEMENT ACTIVATION; ELECTROPHORESIS, CAPILLARY; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NANOMEDICINE; NANOPARTICLES; NANOTECHNOLOGY; PEPTIDE FRAGMENTS; POLYETHYLENE GLYCOLS; PROTEIN BINDING; PROTEIN CONFORMATION; SURFACE PLASMON RESONANCE; THIAZOLES;

EID: 84864273268     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn300489k     Document Type: Article

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