Pregabalin induces hepatic hypoxia and increases endothelialcell proliferation in mice, a process inhibited by dietaryvitamin E supplementation

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 42-56

  Criswell, Kay A ^a   Cook, Jon C ^a   Morse, Dennis ^a   Lawton, Michael ^a   Somps, Christopher ^a   Obert, Leslie ^a   Roy, Marc ^a   Sokolowski, Sharon ^a   Koza taylor, Petra ^a   Colangelo, Jennifer ^a   Navetta, Kimberly ^a   Brady, Joseph ^a   Pegg, David ^a,b   Wojcinski, Zbigniew ^a,c   Rahbari, Ramin ^a   Duddy, Steven ^a,d   Anderson, Timothy ^a  

^a PFIZER INC   (United States)

^b Pharm Dev Solutions   (United States)

^c Integrated Nonclinical Development Solutions Inc   (United States)

^d Drug Development Preclinical Services LLC   (United States)

Author keywords

Endothelial proliferation; ; Hif1 ; Hypoxia; ; Pregabalin;

Indexed keywords

ALPHA TOCOPHEROL; PREGABALIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW; CELL PROLIFERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIVER; MOUSE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; RAT; SPLEEN;

ANIMALS; CELL HYPOXIA; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; ENDOTHELIUM, VASCULAR; FEMALE; GAMMA-AMINOBUTYRIC ACID; LIVER; MICE; VITAMIN E;

MUS; RATTUS; RODENTIA;

EID: 84864153778     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs148     Document Type: Article

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