Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: Evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 22-41

  Criswell, Kay A ^a   Wojcinski, Zbigniew ^b   Pegg, David ^c   Albassam, Mudher ^d   Duddy, Steven ^e   Olsen, Eric ^f   Bailie, Marc ^e   Foote, Stephen ^a   Anderson, Timothy ^a  

^a PFIZER INC   (United States)

^b Drug Development Preclinical Services LLC   (United States)

^c Pharm Dev Solutions   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

^e Integrated Nonclinical Development Solutions   (United States)

^f Data Sciences International   (United States)

Author keywords

Acid base disorder; BFGF; Blood gas; Carcinogenesis; Eryptosis; Erythrophages; Hemangiosarcoma; Hematopoiesis; Megakaryocytes; Nongenotoxic; Platelets; Respiration; Rodent; VEGF

Indexed keywords

ANGIOGENIC FACTOR; BICARBONATE; FIBROBLAST GROWTH FACTOR; PREGABALIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOSARCOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD CARBON DIOXIDE TENSION; BLOOD GAS PARAMETERS; BONE MARROW; BREATHING RATE; CARCINOGENESIS; CELL PROLIFERATION; CHRONIC DISEASE; CONTROLLED STUDY; ENDOTHELIUM CELL; ERYTHROPOIESIS; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; HEMATOPOIETIC CELL; HEMATOPOIETIC TISSUE; HYPOXIA; IMMUNE DYSREGULATION; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MEGAKARYOCYTE; METABOLIC ALKALOSIS; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; PH; PRECURSOR; RAT; RESPIRATORY FUNCTION; SPLEEN; STAINING; THROMBOCYTE; VASCULAR TUMOR;

ANIMALS; BICARBONATES; BLOOD GAS ANALYSIS; ERYTHROPOIESIS; FEMALE; FIBROBLAST GROWTH FACTOR 2; GAMMA-AMINOBUTYRIC ACID; HEMANGIOSARCOMA; MACROPHAGE ACTIVATION; MICE; RATS; RATS, WISTAR; RESPIRATORY FUNCTION TESTS; RETROSPECTIVE STUDIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS; RATTUS; RODENTIA;

EID: 84864140481     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs147     Document Type: Article

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