Kupffer cells participate in 2-butoxyethanol-induced liver hemangiosarcomas

Toxicology

Volumn 270, Issue 2-3, 2010, Pages 131-136

  Kamendulis, Lisa M ^a   Corthals, Stacy M ^a   Klaunig, James E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 Butoxyethanol; Hemangiosarcomas; Kupffer cells

Indexed keywords

2 BUTOXYETHANOL; CLODRONIC ACID; DNA; IRON;

ANGIOSARCOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL FUNCTION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DEPLETION; DNA SYNTHESIS; ENDOTHELIUM CELL; HEMATOCRIT; HEMOLYSIS; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER HEMANGIOSARCOMA; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN WEIGHT; STAINING;

ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; BODY WEIGHT; CARCINOGENS; CELL COUNT; CELL PROLIFERATION; CLODRONIC ACID; DNA, NEOPLASM; DRUG COMPOUNDING; ETHYLENE GLYCOLS; HEMANGIOSARCOMA; HEMATOCRIT; IRON; KUPFFER CELLS; LIPOSOMES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; ORGAN SIZE; SPLEEN;

MUS; RODENTIA;

EID: 77950021471     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.02.006     Document Type: Article

References (32)

1. Bacon B.R., Britton R.S. The pathology of hepatic iron overload: a free radical-mediated process?. Hepatology (Baltimore, MD) 1990, 11:127-137.
2. Boatman R., Corley R., Green T., Klaunig J., Udden M. Review of studies concerning the tumorigenicity of 2-butoxyethanol in B6C3F1 mice and its relevance for human risk assessment. J. Toxicol. Environ. Health 2004, 7:385-398.
3. Bugelski P.J. Sequential histochemical staining for resident and recruited macrophages. J. Leukoc. Biol. 1985, 38:687-696.
4. Campion S.N., Johnson R., Aleksunes L.M., Goedken M.J., van Rooijen N., Scheffer G.L., Cherrington N.J., Manautou J.E. Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G294-G304.
5. Cohen S.M., Storer R.D., Criswell K.A., Doerrer N.G., Dellarco V.L., Pegg D.G., Wojcinski Z.W., Malarkey D.E., Jacobs A.C., Klaunig J.E., Swenberg J.A., Cook J.C. Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance. Toxicol. Sci. 2009, 111:4-18.
6. Corthals S.M., Kamendulis L.M., Klaunig J.E. Mechanisms of 2-butoxyethanol-induced hemangiosarcomas. Toxicol. Sci. 2006, 92:378-386.
7. Elliott B.M., Ashby J. Review of the genotoxicity of 2-butoxyethanol. Mutat. Res. 1997, 387:89-96.
8. Ghanayem B.I., Blair P.C., Thompson M.B., Maronpot R.R., Matthews H.B. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Toxicol. Appl. Pharmacol. 1987, 91:222-234.
9. Ghanayem B.I., Burka L.T., Matthews H.B. Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: role of alcohol and aldehyde dehydrogenases. J. Pharmacol. Exp. Ther. 1987, 242:222-231.
10. Ghanayem B.I., Burka L.T., Sanders J.M., Matthews H.B. Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Drug Metab. Dispos. 1987, 15:478-484.
11. Ghanayem B.I., Sanchez I.M., Matthews H.B. Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms. Toxicol. Appl. Pharmacol. 1992, 112:198-206.
12. Ghanayem B.I., Sullivan C.A. Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans. Hum. Exp. Toxicol. 1993, 12:305-311.
13. Guyton K.Z., Kensler T.W. Oxidative mechanisms in carcinogenesis. Br. Med. Bull. 1993, 49:523-544.
14. Haidl I.D., Jefferies W.A. The macrophage cell surface glycoprotein F4/80 is a highly glycosylated proteoglycan. Eur. J. Immunol. 1996, 26:1139-1146.
15. Henle E.S., Luo Y., Gassmann W., Linn S. Oxidative damage to DNA constituents by iron-mediated fenton reactions. The deoxyguanosine family. J. Biol. Chem. 1996, 271:21177-21186.
16. Hoflack J.C., Durand M.J., Poirier G.G., Maul A., Vasseur P. Alteration in methyl-methanesulfonate-induced poly(ADP-ribosyl)ation by 2-butoxyethanol in Syrian hamster embryo cells. Carcinogenesis 1997, 18:2333-2338.
17. Imlay J.A., Chin S.M., Linn S. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 1988, 240:640-642.
18. Imlay J.A., Linn S. DNA damage and oxygen radical toxicity. Science 1988, 240:1302-1309.
19. Kakhlon O., Cabantchik Z.I. The labile iron pool: characterization, measurement, and participation in cellular processes(1). Free Radic. Biol. Med. 2002, 33:1037-1046.
20. Klaunig J.E., Kamendulis L.M. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 2004, 44:239-267.
21. Klaunig J.E., Kamendulis L.M., Hocevar B.A. Oxidative stress and damage in carcinogenesis. Toxicol. Pathol. 2010, 38:96-109. Epub. December 17, 2009.
22. Laifenfeld D., Gilchrist A., Drubin D., Jorge M., Eddy S.F., Frushour B.P., Ladd B., Obert L.A., Gosink M.M., Cook J.C., Criswell K., Somps C.J., Koza-Taylor P., Elliston K.O., Lawton M.P. The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma. Toxicol. Sci. 2009, Epub. October 2009.
23. NTP, 2000. NTP Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS NO. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Natl. Toxicol. Program Tech. Rep. Ser. 484, 1-290.
24. Nyska A., Haseman J.K., Kohen R., Maronpot R.R. Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice-the National Toxicology Program experience. Toxicol. Pathol. 2004, 32:222-228.
25. Park J., Kamendulis L.M., Klaunig J.E. Mechanisms of 2-butoxyethanol carcinogenicity: studies on Syrian Hamster Embryo (SHE) cell transformation. Toxicol. Sci. 2002, 68:43-50.
26. She H., Xiong S., Lin M., Zandi E., Giulivi C., Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 283:G719-G726.
27. Seisky A.M., Kamendulis L.M., Klaunig J.E. Hepatic effects of 2-butoxyethanol in rodents. Toxicol. Sci. 2002, 70:252-260.
28. van Rooijen N., Poppema A. Efficacy of various water-soluble chelator molecules in the liposome-mediated macrophage " suicide" technique. J. Pharmacol. Toxicol. Methods 1992, 28:217-221.
29. van Rooijen N., Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J. Immunol. Methods 1994, 174:83-93.
30. Welch K.D., Davis T.Z., Van Eden M.E., Aust S.D. Deleterious iron-mediated oxidation of biomolecules. Free Radic. Biol. Med. 2002, 32:577-583.
31. Wintrobe M.M. Clinical Hematology 1981, Lea & Febiger, Philadelphia.
32. Xionga S., Shea H., Sunga C.K., Tsukamoto H. Iron-dependent activation of NF-κB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol 2003, 30:1107-1113.