Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine

International Immunopharmacology

Volumn 14, Issue 2, 2012, Pages 150-156

  Su, Hui Chen ^a   Ma, Ching Ting ^b,c   Yu, Bu Chin ^d   Chien, Yu Chieh ^a,b,c   Tsai, Cheng Chieh ^b,c   Huang, Wei Ching ^c   Lin, Chiou Feng ^c   Chuang, Yeu Hui ^f   Young, Kung Chia ^c   Wang, Jieh Neng ^e   Tsao, Chiung Wen ^b  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

COX 2 PGE2 production; Fluoxetine; GSK 3 ; iNOS NO release; Lipopolysaccharides

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOOXYGENASE 2; FLUOXETINE; GLYCOGEN SYNTHASE KINASE 3BETA; GW 9622; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROSTAGLANDIN E2; PROTEIN KINASE B INHIBITOR; REACTIVE OXYGEN METABOLITE; SERINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE DELETION; INFLAMMATION; MACROPHAGE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; FLUOXETINE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; RNA, SMALL INTERFERING;

EID: 84864124950     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.06.015     Document Type: Article

References (45)

1. M. Bianchi, G. Rossoni, P. Sacerdote, A.E. Panerai, and F. Berti Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat Inflamm Res 44 1995 466 469
2. C. Roumestan, A. Michel, F. Bichon, K. Portet, M. Detoc, and C. Henriquet Anti-inflammatory properties of desipramine and fluoxetine Respir Res 8 2007 35
3. O.M. Abdel-Salam, A.R. Baiuomy, and M.S. Arbid Studies on the anti-inflammatory effect of fluoxetine in the rat Pharmacol Res 49 2004 119 131 (Pubitemid 37485709)
4. O.M. Abdel-Salam, S.M. Nofal, and S.M. El-Shenawy Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat Pharmacol Res 48 2003 157 165 (Pubitemid 36683164)
5. X.Q. Li, H.M. Wang, C.G. Yang, X.H. Zhang, D.D. Han, and H.L. Wang Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats Acta Pharmacol Sin 32 2011 217 222
6. J. De Keyser, G. Laureys, F. Demol, N. Wilczak, J. Mostert, and R. Clinckers Astrocytes as potential targets to suppress inflammatory demyelinating lesions in multiple sclerosis Neurochem Int 57 2010 446 450
7. S.J. Koh, J.M. Kim, I.K. Kim, N. Kim, H.C. Jung, and I.S. Song Fluoxetine inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice Am J Physiol Gastrointest Liver Physiol 301 2011 G9 G19
8. M. Bianchi, P. Sacerdote, and A.E. Panerai Fluoxetine reduces inflammatory edema in the rat: involvement of the pituitary-adrenal axis Eur J Pharmacol 263 1994 81 84 (Pubitemid 24290256)
9. I. Yaron, I. Shirazi, R. Judovich, D. Levartovsky, D. Caspi, and M. Yaron Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures Arthritis Rheum 42 1999 2561 2568 (Pubitemid 30327172)
10. H. Nagai, T. Noguchi, K. Takeda, and H. Ichijo Pathophysiological roles of ASK1-MAP kinase signaling pathways J Biochem Mol Biol 40 2007 1 6 (Pubitemid 46182728)
11. J. Brown, H. Wang, G.N. Hajishengallis, and M. Martin TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk J Dent Res 90 12 2011 417 427
12. Mendes S Dos Santos, A. Candi, M. Vansteenbrugge, M.R. Pignon, H. Bult, and K.Z. Boudjeltia Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: synergistic effects of rapamycin on LPS-induced MMP9-overexpression Cell Signal 21 2009 1109 1122
13. S.M. Dauphinee, and A. Karsan Lipopolysaccharide signaling in endothelial cells Lab Invest 86 2006 9 22 (Pubitemid 43250964)
14. R.S. Jope, C.J. Yuskaitis, and E. Beurel Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics Neurochem Res 32 2007 577 595 (Pubitemid 46481289)
15. G. Gloire, S. Legrand-Poels, and J. Piette NF-kappaB activation by reactive oxygen species: fifteen years later Biochem Pharmacol 72 2006 1493 1505 (Pubitemid 44666727)
16. A. von Knethen, M. Soller, and B. Brune Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis Arch Immunol Ther Exp 55 2007 19 25 (Pubitemid 46294894)
17. J.M. Kaplan, J.A. Cook, P.W. Hake, M. O'Connor, T.J. Burroughs, and B. Zingarelli 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock Shock 24 2005 59 65 (Pubitemid 40946596)
18. J.A. Smith, and M.J. Weidemann Further characterization of the neutrophil oxidative burst by flow cytometry J Immunol Methods 162 1993 261 268
19. J.Y. Park, S.W. Kim, J.K. Lee, W.B. Im, B.K. Jin, and S.H. Yoon Simplified heterocyclic analogues of fluoxetine inhibit inducible nitric oxide production in lipopolysaccharide-induced BV2 cells Biol Pharm Bull 34 2010 538 544
20. E.S. Chung, Y.C. Chung, E. Bok, H.H. Baik, E.S. Park, and J.Y. Park Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress Brain Res 1363 2010 143 150
21. Y. Jin, C.M. Lim, S.W. Kim, J.Y. Park, J.S. Seo, and P.L. Han Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus Brain Res 24 2009 108 116
22. V. Kannen, T. Marini, A. Turatti, M.C. Carvalhob, M.L. Brandaob, and V.A.P. Jaborc Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats Toxicol Lett 204 2011 134 140
23. M. Taler, I. Gil-Ad, L. Lomnitski, L. Lomnitski, E. Baharav, and N. Grunbaum-Novak Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression Eur Neuropsychopharmacol 17 2007 774 780 (Pubitemid 47588862)
24. C.A. Grimes, and R.S. Jope The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog Neurobiol 65 2001 391 426 (Pubitemid 32781670)
25. M. Martin, K. Rehani, R.S. Jope, and S.M. Michalek Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3 Nat Immunol 6 2005 777 784 (Pubitemid 43090463)
26. W.C. Huang, Y.S. Lin, C.Y. Wang, C.C. Tsai, H.C. Tseng, and C.L. Chen Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells Immunology 128 2009 e275 e286
27. L. Dugo, M. Collin, D.A. Allen, N.S.A. Patel, I. Bauer, and E.M.A. Mervaala GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat Crit Care Med 33 2005 1903 1912 (Pubitemid 41306508)
28. B.J. Whittle, C. Varga, A. Posa, A. Molnar, M. Collin, and C. Thiemermann Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta Br J Pharmacol 147 2006 575 582 (Pubitemid 43355056)
29. S. Cuzzocrea, E. Mazzon, R. Di Paola, C. Muià, C. Crisafulli, and L. Dugo Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse Clin Immunol 120 2006 57 67 (Pubitemid 43903390)
30. Y. Wang, W.C. Huang, C.Y. Wang, C.C. Tsai, C.L. Chen, and Y.T. Chang Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis Br J Pharmacol 157 2009 1004 1013
31. X. Hu, P.K. Paik, J. Chen, A. Yarilina, L. Kockeritz, and T.T. Lu IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins Immunity 24 2006 563 574 (Pubitemid 43728157)
32. K.A. Steinbrecher, W. Wilson III, P.C. Cogswell, and A.S. Baldwin Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription Mol Cell Biol 25 2005 8444 8455 (Pubitemid 41369166)
33. J.M. Beaulieu Not only lithium: regulation of glycogen synthase kinase-3 by antipsychotics and serotonergic drugs Int J Neuropsychopharmacol 10 2007 3 6
34. J.M. Beaulieu, R.R. Gainetdinov, and M.G. Caron Akt/GSK3 signaling in the action of psychotropic drugs Annu Rev Pharmacol Toxicol 49 2009 327 347
35. X. Li, K.M. Rosborough, A.B. Friedman, W. Zhu, and K.A. Roth Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics Int J Neuropsychopharmacol 10 2007 7 19 (Pubitemid 46122748)
36. X. Li, W. Zhu, M.S. Roh, A.B. Friedman, K. Rosborough, and R.S. Jope In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain Neuropsychopharmacology 29 2004 1426 1431 (Pubitemid 38982234)
37. D.A. Cross, D.R. Alessi, P. Cohen, M. Andjelkovich, and B.A. Hemmings Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785 789 (Pubitemid 26004411)
38. M. Pap, and G.M. Cooper Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway J Biol Chem 273 1998 19929 19932 (Pubitemid 28377539)
39. J.M. Beaulieu, T.D. Sotnikova, R.R. Gainetdinov, and M.G. Caron Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice J Biol Chem 281 2006 32072 32080 (Pubitemid 46036761)
40. T. Rantamaki, P. Hendolin, A. Kankaanpaa, J. Mijatovic, P. Piepponen, and E. Domenici Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain Neuropsychopharmacology 32 2007 2152 2162 (Pubitemid 47417694)
41. Y. Levkovitz, G. Ben-Shushan, A. Hershkovitz, R. Isaac, I. Gil-Ad, and D. Shvartsman Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases Mol Cell Neurosci 36 2007 305 312 (Pubitemid 47633196)
42. Y.C. Chung, S.R. Kim, J.Y. Park, E.S. Chung, K.W. Park, and S.Y. Won Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation Neuropharmacology 60 2010 963 974
43. A.O. Rosa, M.P. Kaster, R.W. Binfare, S. Morales, E. Martin-Aparicio, and M.L. Navarro-Rico Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1549 1556
44. C.H. Peng, S.H. Chiou, S.J. Chen, Y.C. Chou, H.H. Ku, and C.K. Cheng Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway Eur Neuropsychopharmacol 18 2008 128 140
45. K.P. Shen, S.F. Liou, S.L. Hsieh, I.J. Chen, and B.N. Wu Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2 J Pharm Pharmacol 59 2007 879 889