JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells

Toxicology and Applied Pharmacology

Volumn 263, Issue 1, 2012, Pages 21-31

  Li, Yanchun ^a   Luo, Qiyu ^a   Yuan, Lei ^a   Miao, Caixia ^a   Mu, Xiaoshuo ^a   Xiao, Wei ^b   Li, Jianchun ^a   Sun, Tiemin ^a   Ma, Enlong ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

Asperphenamate; Atg4; Autophagy; JNK; Reactive oxygen species

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; ASPERPHENAMIC ACID; AUTOPHAGY PROTEIN 4; CELL PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; N BENZOYL O [N (1 BENZYLOXYCARBONYL 4 PIPERIDIYLCARBONYL) DEXTRO PHENYLALANYL] DEXTRO PHENYLALANINOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BENZAMIDES; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA; CELL CYCLE; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLALANINE; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84864118315     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.05.018     Document Type: Article

References (52)

1. Adam R., Delvart V., Pascal G., Valeanu A., Castaing D., Azoulay D., Giacchetti S., Paule B., Kunstlinger F., Ghemard O., Levi F., Bismuth H. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann. Surg. 2004, 240:644-657.
2. An H.J., Maeng O., Kang K.H., Lee J.O., Kim Y.S., Paik S.G., Lee H. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J. Biol. Chem. 2006, 281:33939-33948.
3. Azad M.B., Chen Y., Henson E.S., Cizeau J., McMillan-Ward E., Israels S.J., Gibson S.B. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 2008, 4:195-204.
4. Berry D.L., Baehrecke E.H. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 2007, 131:1137-1148.
5. Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365.
6. Boya P., Gonzalez-Polo R.A., Casares N., Perfettini J.L., Dessen P., Larochette N., Metivier D., Meley D., Souguere S., Yoshimori T., Pierron G., Codogno P., Kroemer G. Inhibition of macroautophagy triggers apoptosis. Mol. Cell. Biol. 2005, 25:1025-1040.
7. Bursch W., Ellinger A., Kienzl H., Torok L., Pandey S., Sikorska M., Walker R., Hermann R.S. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 1996, 17:1595-1607.
8. Catalen C.A.N., de Heluani C.S., Kotowicz C., Gedris T.E., Herz W. A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi. Phytochemistry 2003, 64:625-629.
9. Chen Y., McMillan-Ward E., Kong J., Israels S., Gibson S. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 2007, 15:171-182.
10. Chen Y., Azad M.B., Gibson S.B. Methods for detecting autophagy and determining autophagy-induced cell death. Can. J. Physiol. Pharmacol. 2010, 88:285-295.
11. Chen S.Y., Chiu L.Y., Ma M.C., Wang J.S., Chien C.L., Lin W.W. zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy 2011, 7:217-228.
12. Choi C.H., Jung Y.K., Oh S.H. Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis. Mol. Pharmacol. 2010, 78:114-125.
13. Clark A., Hufford C., Robertson L. Two metabolites from Aspergillus flavipes. Lloydia 1977, 40:146-151.
14. Corcelle E., Djerbi N., Mari M., Nebout M., Fiorini C., Fenichel P., Hofman P., Poujeol P., Mograbi B. Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens. Autophagy 2007, 3:57-59.
15. Debnath J., Baehrecke E.H., Kroemer G. Does autophagy contribute to cell death?. Autophagy 2005, 1:66-74.
16. Di X., Shiu R.P., Newsham I.F., Gewirtz D.A. Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin. Biochem. Pharmacol. 2009, 77:1139-1150.
17. Fritsche A., Elfringhoff A., Fabian J., Lehr M. 1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: synthesis, biological activity, metabolic stability and solubilty. Bioorg. Med. Chem. 2008, 16:3489-3500.
18. Imamura S., Nishikawa Y., Ichikawa T., Hattori T., Matsushita Y., Hashiguchi S., Kanzaki N., Iizawa Y., Baba M., Sugihara Y. CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives. Bioorg. Med. Chem. 2005, 13:397-416.
19. Ito H., Daido S., Kanzawa T., Kondo S., Kondo Y. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int. J. Oncol. 2005, 26:1401-1410.
20. Iwamaru A., Kondo Y., Iwado E., Aoki H., Fujiwara K., Yokoyama T., Mills G.B., Kondo S. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007, 26:1840-1851.
21. Jakupovic J., Chen Z.L., Bohlmann F. Artanomaloide, a dimeric guaianolide and phenylalanine derivatives from Artemisia anomala. Phytochemistry 1987, 26:2777-2779.
22. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
23. Kadowaki M., Kanazawa T. Amino acids as regulators of proteolysis. J. Nutr. 2003, 133:2052S-2056S.
24. Kanzawa T., Kondo Y., Ito H., Kondo S., Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 2003, 63:2103-2108.
25. Karna P., Zughaier S., Pannu V., Simmons R., Narayan S., Aneja R. Induction of reactive oxygen species (ROS)-mediated autophagy by a novel microtubule-modulating agent. J. Biol. Chem. 2010, 285:18737-18748.
26. Katayama M., Kawaguchi T., Berger M.S., Pieper R.O. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ. 2007, 14:548-558.
27. Klionsky D.J. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat. Rev. Mol. Cell Biol. 2007, 8:931-937.
28. Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
29. Levine B., Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 2005, 115:2679-2688.
30. Lewanowicz A., Lipinski J., Siedlecka R., Skarzewski J., Baert F. Chiral beta-amino sulfoxides. Synthesis, configurational assignment and conformational analysis based on x-ray, CD, 1H NMR and theoretical calculations. Tetrahedron 1998, 54:6571-6586.
31. Ling J., Wang J., Wang N., Li W., Yi S., Li X. Studies on the chemical constituents of Malt. J. Shenyang Pharm. Univ. 2005, 4:267-270.
32. Mann J. Natural products in cancer chemotherapy: past, present and future. Nat. Rev. Cancer 2002, 2:143-148.
33. McKennon M.J., Meyers A.I., Drauz K., Schwarm M. A Convenient Reduction of Amino Acids and Their Derivatives. J. Org. Chem. 1993, 58:3568-3571.
34. Mizushima N. Methods for monitoring autophagy. Int. J. Biochem. Cell Biol. 2004, 36:2491-2502.
35. Mizushima B., Levine N., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
36. Nakamura Y., Yogosawa S., Izutani Y., Watanabe H., Otsuji E., Sakai T. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol. Cancer 2009, 8:100.
37. Nakano H., Nakajima A., Sakon-Komazawa S., Piao J., Xue X., Okumura K. Reactive oxygen species mediate crosstalk between NF-κB and JNK. Cell Death Differ. 2005, 13:730-737.
38. Ogier-Denis E., Pattingre S., El Benna J., Codogno P. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J. Biol. Chem. 2000, 275:39090-39095.
39. Parka E.J., Choib K.S., Kwon T.K. β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells. Chem. Biol. Interact. 2011, 189:37-44.
40. Poi R., Adityachoudhury N. Occurrence of two rare amides in Medicago polymorpha. Indian J. Chem., Sect B 1986, 25B:1245-1246.
41. Riedl S.J., Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell Biol. 2004, 5:897-907.
42. Schonthal A.H. Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett. 2009, 275:163-169.
43. Scott R.C., Schuldiner O., Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 2004, 7:167-178.
44. Shao Y., Gao Z., Marks P.A., Jiang X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:18030-18035.
45. Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C.B., Tsujimoto Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat. Cell Biol. 2004, 6:1221-1228.
46. Stewart B.W., Kleihues P. World Cancer Report 2008, IARC Press.
47. Talapatra S.K., Pal M.K., Mallik A.K., Talapatra B. Structure and Synthesis of (-)-Anabellamide. A New Phenylalanine Derived Ester Amide From Anaphalis subumbellata: Occurrence of 4'-Hydroxydehydrokawain. J. Nat. Prod. 1983, 46:140-143.
48. Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinaser̈CAkt pathway in human cancer. Nat. Rev. Cancer 2002, 2:489-501.
49. Wong C.H., Iskandar K.B., Yadav S.K., Hirpara J.L., Loh T., Pervaiz S. Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. PLoS One 2010, 5:e9996.
50. Wu P.L., Lin F.W., Wu T.S., Kuoh C.S., Lee K.H., Lee S.J. Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis. Chem. Pharm. Bull. 2004, 52:345-349.
51. Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., Baehreck E.H., Lenardo M.J. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004, 304:1500-1502.
52. Zhang Y., Wu Y., Cheng Y., Zhao Z., Tashiro S., Onodera S., Ikejima T. Fas-mediated autophagy requires JNK activation in HeLa cells. Biochem. Biophys. Res. Commun. 2008, 377:1205-1210.