1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis, biological activity, metabolic stability, and solubility

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3489-3500

  Fritsche, Alexandra ^a   Elfringhoff, Alwine Schulze ^a   Fabian, Jörg ^a   Lehr, Matthias ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Activated ketone; Aqueous solubility; Cytosolic phospholipase A2 ; Indole 2 carboxylic acid; Inhibitors; Metabolic stability

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; PHOSPHOLIPASE A2;

ARTICLE; CYTOSOL; DRUG ACTIVITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; LIVER MICROSOME; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; THROMBOCYTE;

BLOOD PLATELETS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; GROUP IV PHOSPHOLIPASES A2; HUMANS; INDOLES; MOLECULAR STRUCTURE; PROPIONIC ACIDS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 41649107806     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.019     Document Type: Article

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