Network analysis and proteomic identification of vimentin as a key regulator associated with invasion and metastasis in human hepatocellular carcinoma cells

Journal of Proteomics

Volumn 75, Issue 15, 2012, Pages 4676-4692

  Pan, Tai Long ^a   Wang, Pei Wen ^a   Huang, Chao Cheng ^b   Yeh, Chau Ting ^c   Hu, Tsung Hui ^b   Yu, Jau Song ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Cytoskeleton; Hepatocellular carcinoma; Metastasis; Proteomics; Ubiquitination; Vimentin

Indexed keywords

BIOLOGICAL MARKER; CELL PROTEIN; GELATINASE B; PROTEOME; REGULATOR PROTEIN; UBIQUITIN; VIMENTIN;

ARTICLE; CANCER INVASION; CANCER SURVIVAL; CELL ADHESION; CELL MOTILITY; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LONG TERM SURVIVAL; METASTASIS; NETWORK ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; RNA INTERFERENCE;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOSKELETON; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PROTEOME; PROTEOMICS; TUMOR MARKERS, BIOLOGICAL; VIMENTIN;

EID: 84864102943     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.02.017     Document Type: Article

References (49)

1. Pang R.W., Joh J.W., Johnson P.J., Monden M., Pawlik T.M., Poon R.T. Biology of hepatocellular carcinoma. Ann Surg Oncol 2008, 15(4):962-971.
2. Zhou X.D. Recurrence and metastasis of hepatocellular carcinoma: progress and prospects. Hepatobiliary Pancreat Dis Int 2002, 1(1):35-41.
3. Savagner P. The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol 2010, 21(Suppl. 7):vii89-vii92.
4. Yilmaz M., Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009, 28(1-2):15-33.
5. Satelli A., Li S. Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci 2011, 68(18):3033-3046.
6. Ivaska J., Pallari H.M., Nevo J., Eriksson J.E. Novel functions of vimentin in cell adhesion, migration, and signaling. Exp Cell Res 2007, 313(10):2050-2062.
7. Hu L., Lau S.H., Tzang C.H., Wen J.M., Wang W., Xie D., et al. Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 2004, 23(1):298-302.
8. Yilmaz M., Christofori G., Lehembre F. Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med 2007, 13(12):535-541.
9. Mota S., Mendes M., Freitas N., Penque D., Coelho A.V., Cunha C. Proteome analysis of a human liver carcinoma cell line stably expressing hepatitis delta virus ribonucleoproteins. J Proteomics 2009, 72(4):616-627.
10. Pan T.L., Hung Y.C., Wang P.W., Chen S.T., Hsu T.K., Sintupisut N., et al. Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells. Proteomics 2010, 10(5):914-929.
11. Wang P.I., Marcotte E.M. It's the machine that matters: predicting gene function and phenotype from protein networks. J Proteomics 2010, 73(11):2277-2289.
12. Kitteringham N.R., Abdullah A., Walsh J., Randle L., Jenkins R.E., Sison R., et al. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. J Proteomics 2010, 73(8):1612-1631.
13. Hu T.H., Huang C.C., Lin P.R., Chang H.W., Ger L.P., Lin Y.W., et al. Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. Cancer 2003, 97(8):1929-1940.
14. Pan T.L., Wang P.W., Huang C.M., Chen C.C., Fang J.Y. Elucidation of the percutaneous absorption of chromium compounds by functional proteomics. Proteomics 2009, 9(22):5120-5131.
15. Dalby B., Cates S., Harris A., Ohki E.C., Tilkins M.L., Price P.J., et al. Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications. Methods 2004, 33(2):95-103.
16. Pan T.L., Wang P.W., Leu Y.L., Wu T.H., Wu T.S. Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G(2)/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway. J Ethnopharmacol 2012, 10.1016/j.jep.2011.12.028.
17. Körner A., Mudduluru G., Manegold C., Allgayer H. Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules. Br J Cancer 2010, 103(6):802-811.
18. Van Lonkhuyzen D.R., Hollier B.G., Shooter G.K., Leavesley D.I., Upton Z. Chimeric vitronectin:insulin-like growth factor proteins enhance cell growth and migration through co-activation of receptors. Growth Factors 2007, 25(5):295-308.
19. Yeh H.C., Lin S.M., Chen M.F., Pan T.L., Wang P.W., Yeh C.T. Evaluation of serum matrix metalloproteinase (MMP)-9 to MMP-2 ratio as a biomarker in hepatocellular carcinoma. Hepatogastroenterology 2010, 57(97):98-102.
20. McGinley J.N., Thompson H.J. Quantitative assessment of mammary gland density in rodents using digital image analysis. Biol Proced Online 2011, 13(1):4.
21. Hung Y.C., Wang P.W., Pan T.L. Functional proteomics reveal the effect of Salvia miltiorrhiza aqueous extract against vascular atherosclerotic lesions. Biochim Biophys Acta 2010, 1804(6):1310-1321.
22. Pan T.L., Wang P.W., Lee W.R., Fang C.L., Chen C.C., Huang C.M., et al. Systematic evaluations of skin damage irradiated by an erbium:YAG laser: histopathologic analysis, proteomic profiles, and cellular response. J Dermatol Sci 2010, 58(1):8-18.
23. Pan T.L., Wang P.W., Huang C.C., Goto S., Chen C.L. Expression, by functional proteomics, of spontaneous tolerance in rat orthotopic liver transplantation. Immunology 2004, 113(1):57-64.
24. Dezso Z., Nikolsky Y., Nikolskaya T., Miller J., Cherba D., Webb C., et al. Identifying disease-specific genes based on their topological significance in protein networks. BMC Syst Biol 2009, 3:36.
25. Lauwers G.Y., Terris B., Balis U.J., Batts K.P., Regimbeau J.M., Chang Y., et al. International Cooperative Study Group on Hepatocellular Carcinoma. Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index. Am J Surg Pathol 2002, 26(1):25-34.
26. Paccione R.J., Miyazaki H., Patel V., Waseem A., Gutkind J.S., Zehner Z.E., et al. Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Mol Cancer Ther 2008, 7(9):2894-2903.
27. Dandachi N., Hauser-Kronberger C., Moré E., Wiesener B., Hacker G.W., Dietze O., et al. Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins. J Pathol 2001, 193(2):181-189.
28. Lahat G., Zhu Q.S., Huang K.L., Wang S., Bolshakov S., Liu J., et al. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One 2010, 5(4):e10105.
29. McInroy L., Määttä A. Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem Biophys Res Commun 2007, 360(1):109-114.
30. Sun S., Poon R.T., Lee N.P., Yeung C., Chan K.L., Ng I.O., et al. Proteomics of hepatocellular carcinoma: serum vimentin as a surrogate marker for small tumors (≤ or =2cm). J Proteome Res 2010, 9(4):1923-1930.
31. Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J Viral Hepat 2011, 18(10):e568-e577.
32. Burgstaller G., Gregor M., Winter L., Wiche G. Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol Biol Cell 2010, 21(19):3362-3375.
33. Bhattacharya R., Gonzalez A.M., Debiase P.J., Trejo H.E., Goldman R.D., Flitney F.W., et al. Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. J Cell Sci 2009, 122(9):1390-1400.
34. Gad A., Lach S., Crimaldi L., Gimona M. Plectin deposition at podosome rings requires myosin contractility. Cell Motil Cytoskeleton 2008, 65(8):614-625.
35. Spurny R., Gregor M., Castañón M.J., Wiche G. Plectin deficiency affects precursor formation and dynamics of vimentin networks. Exp Cell Res 2008, 314(19):3570-3580.
36. Mierke C.T. The role of vinculin in the regulation of the mechanical properties of cells. Cell Biochem Biophys 2009, 53(3):115-126.
37. Takkunen M., Hukkanen M., Liljeström M., Grenman R., Virtanen I. Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia. J Cell Mol Med 2010, 14(6B):1569-1593.
38. Zhang X., Jiang G., Cai Y., Monkley S.J., Critchley D.R., Sheetz M.P. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol 2008, 10(9):1062-1068.
39. Bedolla R.G., Wang Y., Asuncion A., Chamie K., Siddiqui S., Mudryj M.M., et al. Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases. Clin Cancer Res 2009, 15(3):788-796.
40. Vadlamudi R.K., Li F., Adam L., Nguyen D., Ohta Y., Stossel T.P., et al. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 2002, 4(9):681-690.
41. Gilbert S., Ruel A., Loranger A., Marceau N. Switch in Fas-activated death signaling pathway as result of keratin 8/18-intermediate filament loss. Apoptosis 2008, 13(12):1479-1493.
42. Bordeleau F., Galarneau L., Gilbert S., Loranger A., Marceau N. Keratin 8/18 modulation of protein kinase C-mediated integrin-dependent adhesion and migration of liver epithelial cells. Mol Biol Cell 2010, 21(10):1698-1713.
43. Bornheim R., Müller M., Reuter U., Herrmann H., Büssow H., Magin T.M. A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice. J Cell Sci 2008, 121(22):3737-3746.
44. Snider N.T., Weerasinghe S.V., Iñiguez-Lluhí J.A., Herrmann H., Omary M.B. Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem 2011, 286(3):2273-2284.
45. Popoff M.R., Geny B. Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins. Biochim Biophys Acta 2009, 1788(4):797-812.
46. Chen Y., Lu Q., Schneeberger E.E., Goodenough D.A. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell 2000, 11(3):849-862.
47. Sihag R.K., Inagaki M., Yamaguchi T., Shea T.B., Pant H.C. Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments. Exp Cell Res 2007, 313(10):2098-2109.
48. Bindhu O.S., Ramadas K., Sebastian P., Pillai M.R. High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma. Head Neck 2006, 28(10):916-925.
49. Li J., Lau G.K., Chen L., Dong S.S., Lan H.Y., Huang X.R., et al. Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression. PLoS One 2011, 6(7):e21816.