Nuclear versus cytoplasmic localization of filamin a in prostate cancer: Immunohistochemical correlation with metastases

Clinical Cancer Research

Volumn 15, Issue 3, 2009, Pages 788-796

  Bedolla, Roble G ^a   Wang, Yu ^b,c   Asuncion, Alfredo ^b   Chamie, Karim ^c   Siddiqui, Salma ^b   Mudryj, Maria M ^b,c   Prihoda, Thomas J ^a   Siddiqui, Javed ^d   Chinnaiyan, Arul M ^d   Mehra, Rohit ^d   De Vere White, Ralph W ^c   Ghosh, Paramita M ^b,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b VA NORTHERN CALIFORNIA HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FILAMIN A; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE;

ADVANCED CANCER; ARTICLE; CANCER GROWTH; CANCER PATIENT; CANCER TISSUE; CARCINOMA IN SITU; CELL INVASION; CELL MIGRATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE TUMOR; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ANDROGEN ANTAGONISTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; CONTRACTILE PROTEINS; CYTOPLASM; DRUG RESISTANCE, NEOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROFILAMENT PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; TISSUE ARRAY ANALYSIS;

EID: 61349085591     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-1402     Document Type: Article

References (24)

1. Gorlin JB, Yamin R, Egan S, et al. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol 1990;111:1089-105.
2. Feng Y, Walsh CA. The many faces of filamin: a versatile molecular scaffold for cell motility and signalling. Nat Cell Biol 2004;6: 1034-8.
3. Robertson SP,Twigg SR, Sutherland-Smith AJ, et al. Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. Nat Genet 2003;33:487-91.
4. van der Flier A, Sonnenberg A. Structural and functional aspects of filamins. Biochim Biophys Acta 2001;1538:99-117.
5. Anilkumar G, Rajasekaran SA,Wang S, Hankinson O, Bander NH, Rajasekaran AK. Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALA Dase activity. Cancer Res 2003;63:2645-8.
6. Ghosh A, Heston WD. Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J Cell Biochem 2004;91:528-39.
7. Rajasekaran AK, Anilkumar G, Christiansen JJ. Is prostate-specific membrane antigen a multifunctional protein? Am J Physiol 2005;288:C975-81.
8. Loy CJ, Sim KS,Yong EL. Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions. Proc Natl Acad Sci U S A 2003; 100:4562-7.
9. Ozanne DM, Brady ME, Cook S, Gaughan L, Neal DE, Robson CN. Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin. Mol Endocrinol 2000;14:1618-26.
10. Wang Y, Kreisberg JI, Bedolla RG, Mikhailova M, de Vere White RW, Ghosh PM. A 90 k Da fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene 2007;26: 6061-70.
11. Browne KA, Johnstone RW, Jans DA, Trapani JA. Filamin (280-k Da actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis. J Biol Chem 2000;275:39262-6.
12. Jay D, Garcia EJ, Lara JE, Medina MA, de la Luz Ibarra M. Determination of a cAMP-dependent protein kinase phosphorylation site in the C-terminal region of human endothelial actin-binding protein. Arch Biochem Biophys 2000;377:80-4.
13. Jay D, Garcia EJ, de la Luz Ibarra M. In situ determination of a PKA phosphorylation site in the Cterminal region of filamin. Mol Cell Biochem 2004;260:49-53.
14. Woo MS, Ohta Y, Rabinovitz I, Stossel TP, Blenis J. Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol Cell Biol 2004;24:3025-35.
15. Tigges U, Koch B, Wissing J, Jockusch BM, Ziegler WH. The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase Ca. J Biol Chem 2003;278:23561-9.
16. Rubin MA, Putzi M,Mucci N, et al.Rapid ("warm") autopsy study for procurement of metastatic prostate cancer. Clin Cancer Res 2000;6:1038-45.
17. Shah RB, Mehra R, Chinnaiyan AM, et al. Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res 2004;64:9209-16.
18. Porter RM, Holme TC, Newman EL, Hopwood D, Wilkinson JM, Cuschieri A. Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer. J Pathol 1993;170: 435-40.
19. Bedolla R, Prihoda TJ, Kreisberg JI, et al. Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin Cancer Res 2007;13: 3860-7.
20. Kreisberg JI, Malik SN, Prihoda TJ, et al. Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer. Cancer Res 2004; 64:5232-6.
21. Vadlamudi RK, Li F, Adam L, et al. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 2002;4:681-90.
22. Stossel TP, Condeelis J, Cooley L, et al. Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol 2001;2:138-45.
23. Ott I, Fischer EG, Miyagi Y, Mueller BM, Ruf W. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280. J Cell Biol 1998;140:1241-53.
24. Bourguignon LY, Gilad E, Peyrollier K. Heregulin-mediated Erb B2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. J Biol Chem 2007;282: 19426-41.