Methyllycaconitine: A non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - In vivo target localization and biodistribution in rat brain

Journal of Pharmacological and Toxicological Methods

Volumn 66, Issue 1, 2012, Pages 22-28

  Nirogi, Ramakrishna ^a   Kandikere, Vishwottam ^a   Bhyrapuneni, Gopinadh ^a   Saralaya, Ramanatha ^a   Muddana, Nageswararao ^a   Komarneni, Prashanth ^a  

^a SUVEN LIFE SCIENCES LTD   (India)

Author keywords

7 nAChRs; ABBF (N (3R) 1 azabicyclo 2.2.2 oct 3 yl 7 2 (methoxy) phenyl 1 benzofuran 2 carboxamide); LC MS MS; Methyllycaconitine; Nicotine; PNU282987 (N (3R) 1 azabicyclo 2.2.2 oct 3 yl 4 chlorobenzamide)

Indexed keywords

4 CHLORO N (3 QUINUCLIDINYL)BENZAMIDE; BUNGAROTOXIN RECEPTOR; METHYLLYCACONITINE; NICOTINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BRAIN MAPPING; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; DISTRIBUTION VOLUME; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG STABILITY; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HYPOTHALAMUS; IN VIVO STUDY; LIGAND BINDING; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MESENCEPHALON; NONHUMAN; PROTEIN LOCALIZATION; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACONITINE; ANIMALS; BENZAMIDES; BENZOFURANS; BICYCLO COMPOUNDS; BINDING SITES; BRAIN; BRAIN CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MALE; NICOTINIC ANTAGONISTS; QUINUCLIDINES; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC;

RATTUS; RATTUS NORVEGICUS;

EID: 84864098090     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2012.05.003     Document Type: Article

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