Quantification of methyllycaconitine, selective α7 nicotinic receptor antagonist, in rodent plasma and brain tissue by liquid chromatography tandem mass spectrometry - application to neuropharmacokinetics of methyllycaconitine in rats

Biomedical Chromatography

Volumn 25, Issue 11, 2011, Pages 1273-1282

  Nirogi, Ramakrishna ^a   Kandikere, Vishwottam ^a   Komarneni, Prashanth ^a   Aleti, Raghupathi ^a   Boggavarapu, Rajesh ^a   Bhyrapuneni, Gopinadh ^a   Muddana, Nageswararao ^a   Mukkanti, K ^b  

^a SUVEN LIFE SCIENCES LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Brain tissue; Liquid chromatography tandem mass spectrometry; Methyllycaconitine; Pharmacokinetic study; Plasma

Indexed keywords

BODY FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POSITIVE IONS; RATS; TISSUE;

BRAIN TISSUE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METHYLLYCACONITINE; NICOTINIC RECEPTOR; PHARMACOKINETIC STUDIES; RAT PLASMA; RATS BRAIN; RECEPTOR ANTAGONISTS; RODENT BRAIN;

PHARMACOKINETICS;

ACETONITRILE; METHYLLYCACONITINE; PROPRANOLOL; ACONITINE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DYNAMICS; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; BRAIN; BRAIN LEVEL; METABOLISM; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

RATTUS; RODENTIA;

ACONITINE; ANIMALS; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; LINEAR MODELS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 80053577162     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1603     Document Type: Article

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