In vivo receptor occupancy assay of histamine H 3 receptor antagonist in rats using non-radiolabeled tracer

Journal of Pharmacological and Toxicological Methods

Volumn 65, Issue 3, 2012, Pages 115-121

  Nirogi, Ramakrishna ^a   Kandikere, Vishwottam ^a   Bhyrapuneni, Gopinadh ^a   Muddana, Nageswararao ^a   Saralaya, Ramanatha ^a   Ponnamaneni, Ranjith Kumar ^a   Manoharan, Arun Kumar ^a  

^a SUVEN LIFE SCIENCES LTD   (India)

Author keywords

Ciproxifan; GSK189254; GSK334429; Histamine H 3 receptor occupancy; Mass spectroscopy; Thioperamide

Indexed keywords

6 (3 CYCLOBUTYL 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 7 YLOXY) N METHYLNICOTINAMIDE; CARBON 11; CIPROXIFAN; GSK 334429; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; THIOPERAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG EXPOSURE; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG UPTAKE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IN VIVO STUDY; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; NONHUMAN; RAT; RECEPTOR OCCUPANCY;

ANIMALS; AZEPINES; BIOLOGICAL ASSAY; BRAIN; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; HISTAMINE H3 ANTAGONISTS; IMIDAZOLES; MALE; PIPERIDINES; PROTEIN BINDING; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, HISTAMINE H3; TANDEM MASS SPECTROMETRY;

ANIMALIA; RATTUS; RATTUS NORVEGICUS; SUS;

EID: 84861482163     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2012.03.003     Document Type: Article

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