메뉴 건너뛰기




Volumn 50, Issue 4, 2009, Pages 943-948

Fenofibrate, a peroxisome proliferator-activated receptor-α agonist, exerts anticonvulsive properties

Author keywords

Antiepileptic drug; Fenofibrate; Ketogenic diet; Pentylenetetrazol; PPAR; Status epilepticus

Indexed keywords

3 HYDROXYBUTYRIC ACID; FENOFIBRATE; LITHIUM; PENTETRAZOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PILOCARPINE;

EID: 63849178838     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01901.x     Document Type: Article
Times cited : (40)

References (56)
  • 1
    • 33644811740 scopus 로고    scopus 로고
    • The utility of testing pentylenetetrazol threshold
    • Auvin S., Shin D, Mazarati A, Sankar R 2006) The utility of testing pentylenetetrazol threshold. Epilepsia 47 : 662 663.
    • (2006) Epilepsia , vol.47 , pp. 662-663
    • Auvin, S.1    Shin, D.2    Mazarati, A.3    Sankar, R.4
  • 2
    • 63849250076 scopus 로고    scopus 로고
    • Inflammation, epilepsy, and anti-inflammatory therapies
    • In. Pellock, J.M. Bourgeois, B. Dodson, W. Nordli, D.R.Jr. Sankar, R. Eds). Demos Medical Publishing. New York. pp.
    • Auvin S, Sankar R 2008) Inflammation, epilepsy, and anti-inflammatory therapies. In Pellock JM, Bourgeois B, Dodson W, Nordli DR Jr., Sankar R (Eds) Pediatric epilepsy: diagnosis and therapy. 3rd ed. Demos Medical Publishing, New York, pp. 751 758.
    • (2008) Pediatric Epilepsy: Diagnosis and Therapy. 3rd Ed. , pp. 751-758
    • Auvin, S.1    Sankar, R.2
  • 4
    • 0034057069 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the cardiovascular system
    • Bishop-Bailey D 2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br J Pharmacol 129 : 823 834.
    • (2000) Br J Pharmacol , vol.129 , pp. 823-834
    • Bishop-Bailey, D.1
  • 5
    • 0041887308 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Regulation of transcriptional activities and roles in inflammation
    • Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C 2003) Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol 85 : 267 273.
    • (2003) J Steroid Biochem Mol Biol , vol.85 , pp. 267-273
    • Blanquart, C.1    Barbier, O.2    Fruchart, J.C.3    Staels, B.4    Glineur, C.5
  • 6
    • 0037185379 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids induce ischemic and epileptic tolerance
    • Blondeau N, Widmann C, Lazdunski M, Heurteaux C 2002) Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109 : 231 241.
    • (2002) Neuroscience , vol.109 , pp. 231-241
    • Blondeau, N.1    Widmann, C.2    Lazdunski, M.3    Heurteaux, C.4
  • 8
    • 0032901064 scopus 로고    scopus 로고
    • A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat
    • Bough KJ, Eagles DA 1999) A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia 40 : 138 143.
    • (1999) Epilepsia , vol.40 , pp. 138-143
    • Bough, K.J.1    Eagles, D.A.2
  • 10
    • 0033856825 scopus 로고    scopus 로고
    • PPAR agonists as direct modulators of the vessel wall in cardiovascular disease
    • Buchan KW, Hassall DG 2000) PPAR agonists as direct modulators of the vessel wall in cardiovascular disease. Med Res Rev 20 : 350 366.
    • (2000) Med Res Rev , vol.20 , pp. 350-366
    • Buchan, K.W.1    Hassall, D.G.2
  • 11
    • 0034693323 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B
    • Chung SW, Kang BY, Kim SH, Pak YK, Cho D, Trinchieri G, Kim TS 2000) Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. J Biol Chem 275 : 32681 32687.
    • (2000) J Biol Chem , vol.275 , pp. 32681-32687
    • Chung, S.W.1    Kang, B.Y.2    Kim, S.H.3    Pak, Y.K.4    Cho, D.5    Trinchieri, G.6    Kim, T.S.7
  • 12
    • 0036236378 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
    • Cullingford TE, Dolphin CT, Sato H 2002) The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. Neuropharmacology 42 : 724 730.
    • (2002) Neuropharmacology , vol.42 , pp. 724-730
    • Cullingford, T.E.1    Dolphin, C.T.2    Sato, H.3
  • 13
    • 1042265019 scopus 로고    scopus 로고
    • The ketogenic diet; Fatty acids, fatty acid-activated receptors and neurological disorders
    • Cullingford TE 2004) The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. Prostaglandins Leukot Essent Fatty Acids 70 : 253 264.
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 253-264
    • Cullingford, T.E.1
  • 14
    • 20744431937 scopus 로고    scopus 로고
    • The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy
    • Dahlin M, Elfving A, Ungerstedt U, Amark P 2005) The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy. Epilepsy Res 64 : 115 125.
    • (2005) Epilepsy Res , vol.64 , pp. 115-125
    • Dahlin, M.1    Elfving, A.2    Ungerstedt, U.3    Amark, P.4
  • 15
    • 0029003889 scopus 로고
    • Design features of a five-year Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT)
    • de FU, Ericsson CG, Hamsten A, Nilsson J 1995) Design features of a five-year Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT). Drugs Exp Clin Res 21 : 105 124.
    • (1995) Drugs Exp Clin Res , vol.21 , pp. 105-124
    • De F., U.1    Ericsson, C.G.2    Hamsten, A.3    Nilsson, J.4
  • 16
    • 0029845294 scopus 로고    scopus 로고
    • Secondary preventive potential of lipid-lowering drugs. the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT)
    • de FU, Ericsson CG, Grip L, Nilsson J, Svane B, Hamsten A 1996) Secondary preventive potential of lipid-lowering drugs. The Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT). Eur Heart J 17 (Suppl. F 37 42.
    • (1996) Eur Heart J , vol.17 , Issue.SUPPL. F , pp. 37-42
    • De F., U.1    Ericsson, C.G.2    Grip, L.3    Nilsson, J.4    Svane, B.5    Hamsten, A.6
  • 17
    • 0030905352 scopus 로고    scopus 로고
    • Retardation of coronary atherosclerosis: The Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT) and other angiographic trials
    • de FU, Ericsson CG, Grip L, Nilsson J, Svane B, Hamsten A 1997) Retardation of coronary atherosclerosis: the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT) and other angiographic trials. Cardiovasc Drugs Ther 11 (Suppl. 1 257 263.
    • (1997) Cardiovasc Drugs Ther , vol.11 , Issue.SUPPL. 1 , pp. 257-263
    • De F., U.1    Ericsson, C.G.2    Grip, L.3    Nilsson, J.4    Svane, B.5    Hamsten, A.6
  • 18
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    • Delerive P, De BK, Besnard S, Vanden BW, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B 1999) Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem 274 : 32048 32054.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De B., K.2    Besnard, S.3    Vanden, B.W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 21
    • 0031773486 scopus 로고    scopus 로고
    • The efficacy of the ketogenic diet-1998: A prospective evaluation of intervention in 150 children
    • Freeman JM, Vining EP, Pillas DJ, Pyzik PL, Casey JC, Kelly LM 1998) The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 102 : 1358 1363.
    • (1998) Pediatrics , vol.102 , pp. 1358-1363
    • Freeman, J.M.1    Vining, E.P.2    Pillas, D.J.3    Pyzik, P.L.4    Casey, J.C.5    Kelly, L.M.6
  • 22
    • 0342506477 scopus 로고    scopus 로고
    • Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lipid Coronary Angiography Trial (LOCAT) Study Group
    • Frick MH, Syvanne M, Nieminen MS, Kauma H, Majahalme S, Virtanen V, Kesaniemi YA, Pasternack A, Taskinen MR 1997) Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lipid Coronary Angiography Trial (LOCAT) Study Group. Circulation 96 : 2137 2143.
    • (1997) Circulation , vol.96 , pp. 2137-2143
    • Frick, M.H.1    Syvanne, M.2    Nieminen, M.S.3    Kauma, H.4    Majahalme, S.5    Virtanen, V.6    Kesaniemi, Y.A.7    Pasternack, A.8    Taskinen, M.R.9
  • 23
    • 0032816777 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
    • Fruchart JC, Duriez P, Staels B 1999) Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 10 : 245 257.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 245-257
    • Fruchart, J.C.1    Duriez, P.2    Staels, B.3
  • 24
    • 0035193079 scopus 로고    scopus 로고
    • PPARS, metabolic disease and atherosclerosis
    • Fruchart JC, Staels B, Duriez P 2001) PPARS, metabolic disease and atherosclerosis. Pharmacol Res 44 : 345 352.
    • (2001) Pharmacol Res , vol.44 , pp. 345-352
    • Fruchart, J.C.1    Staels, B.2    Duriez, P.3
  • 25
    • 0031856716 scopus 로고    scopus 로고
    • Baseline characteristics of patients participating in the Bezafibrate Infarction Prevention (BIP) Study
    • Goldbourt U, Brunner D, Behar S, Reicher-Reiss H 1998) Baseline characteristics of patients participating in the Bezafibrate Infarction Prevention (BIP) Study. Eur Heart J 19 (Suppl. H H42 H47.
    • (1998) Eur Heart J , vol.19 , Issue.SUPPL. H
    • Goldbourt, U.1    Brunner, D.2    Behar, S.3    Reicher-Reiss, H.4
  • 29
    • 0020521863 scopus 로고
    • Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver
    • Lalwani ND, Reddy MK, Qureshi SA, Sirtori CR, Abiko Y, Reddy JK 1983) Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver. Hum Toxicol 2 : 27 48.
    • (1983) Hum Toxicol , vol.2 , pp. 27-48
    • Lalwani, N.D.1    Reddy, M.K.2    Qureshi, S.A.3    Sirtori, C.R.4    Abiko, Y.5    Reddy, J.K.6
  • 31
    • 0025817126 scopus 로고
    • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models
    • Loscher W, Honack D, Fassbender CP, Nolting B 1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res 8 : 171 189.
    • (1991) Epilepsy Res , vol.8 , pp. 171-189
    • Loscher, W.1    Honack, D.2    Fassbender, C.P.3    Nolting, B.4
  • 32
    • 34147189503 scopus 로고    scopus 로고
    • Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels
    • Ma W, Berg J, Yellen G 2007) Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. J Neurosci 27 : 3618 3625.
    • (2007) J Neurosci , vol.27 , pp. 3618-3625
    • Ma, W.1    Berg, J.2    Yellen, G.3
  • 34
    • 33646524699 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and inflammation
    • Moraes LA, Piqueras L, Bishop-Bailey D 2006) Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 110 : 371 385.
    • (2006) Pharmacol Ther , vol.110 , pp. 371-385
    • Moraes, L.A.1    Piqueras, L.2    Bishop-Bailey, D.3
  • 35
    • 47249105094 scopus 로고    scopus 로고
    • The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population-based study in a Western European country
    • Picot MC, Baldy-Moulinier M, Daures JP, Dujols P, Crespel A 2008) The prevalence of epilepsy and pharmacoresistant epilepsy in adults: a population-based study in a Western European country. Epilepsia 49 : 1230 1238.
    • (2008) Epilepsia , vol.49 , pp. 1230-1238
    • Picot, M.C.1    Baldy-Moulinier, M.2    Daures, J.P.3    Dujols, P.4    Crespel, A.5
  • 36
    • 0021906711 scopus 로고
    • A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat
    • Pollack GM, Shen DD 1985) A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. J Pharmacol Methods 13 : 135 146.
    • (1985) J Pharmacol Methods , vol.13 , pp. 135-146
    • Pollack, G.M.1    Shen, D.D.2
  • 37
    • 62149118510 scopus 로고    scopus 로고
    • Anticonvulsant effects of Linolenic acid are unrelated to brain phospholipid cell membrane compositions
    • July 24 [Epub ahead of print].
    • Porta N, Bourgois B, Galabert C, Lecointe C, Cappy P, Bordet R, Vallée L, Auvin S (2008) Anticonvulsant effects of Linolenic acid are unrelated to brain phospholipid cell membrane compositions. Epilepsia July 24 [Epub ahead of print].
    • (2008) Epilepsia
    • Porta, N.1    Bourgois, B.2    Galabert, C.3    Lecointe, C.4    Cappy, P.5    Bordet, R.6    Vallée, L.7    Auvin, S.8
  • 38
    • 0242269459 scopus 로고    scopus 로고
    • Anticonvulsant efficiency, behavioral performance and cortisol levels: A comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3)
    • Rabinovitz S, Mostofsky DI, Yehuda S 2004) Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). Psychoneuroendocrinology 29 : 113 124.
    • (2004) Psychoneuroendocrinology , vol.29 , pp. 113-124
    • Rabinovitz, S.1    Mostofsky, D.I.2    Yehuda, S.3
  • 39
    • 0001425525 scopus 로고
    • Nutrition
    • In. Baker, H. Lindsey, J. Weisbroth, S. Eds). Academic Press. Orlando. pp.
    • Rogers A 1979) Nutrition. In Baker H, Lindsey J, Weisbroth S (Eds) The laboratory rat. Academic Press, Orlando, pp. 123 152.
    • (1979) The Laboratory Rat. , pp. 123-152
    • Rogers, A.1
  • 40
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB, Faas FH, Linares E, Schaefer EJ, Schectman G, Wilt TJ, Wittes J 1999) Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 341 : 410 418.
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 41
    • 23944435868 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of genes of lipid metabolism
    • Sampath H, Ntambi JM 2005) Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr 25 : 317 340.
    • (2005) Annu Rev Nutr , vol.25 , pp. 317-340
    • Sampath, H.1    Ntambi, J.M.2
  • 42
    • 0027137896 scopus 로고
    • Some aspects of prognosis in the epilepsies: A review
    • Sander JW 1993) Some aspects of prognosis in the epilepsies: a review. Epilepsia 34 : 1007 1016.
    • (1993) Epilepsia , vol.34 , pp. 1007-1016
    • Sander, J.W.1
  • 43
    • 34047213327 scopus 로고    scopus 로고
    • Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat
    • Sheikh K, Camejo G, Lanne B, Halvarsson T, Landergren MR, Oakes ND 2007) Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. Am J Physiol Endocrinol Metab 292 : E1157 E1165.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Sheikh, K.1    Camejo, G.2    Lanne, B.3    Halvarsson, T.4    Landergren, M.R.5    Oakes, N.D.6
  • 44
    • 0033227696 scopus 로고    scopus 로고
    • Neuroactive amino acids in focally epileptic human brain: A review
    • Sherwin AL 1999) Neuroactive amino acids in focally epileptic human brain: a review. Neurochem Res 24 : 1387 1395.
    • (1999) Neurochem Res , vol.24 , pp. 1387-1395
    • Sherwin, A.L.1
  • 45
    • 0019776851 scopus 로고
    • Effect of hypolipidaemic drugs on hepatomegaly and micro-bodies in the rat. A new approach to the nature of hepatic peroxisomal proliferation
    • Sim AK, Spencer A, Metz G, Rushton B 1981) Effect of hypolipidaemic drugs on hepatomegaly and micro-bodies in the rat. A new approach to the nature of hepatic peroxisomal proliferation. Arzneimittelforschung 31 : 1119 1126.
    • (1981) Arzneimittelforschung , vol.31 , pp. 1119-1126
    • Sim, A.K.1    Spencer, A.2    Metz, G.3    Rushton, B.4
  • 46
    • 41749121711 scopus 로고    scopus 로고
    • Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids
    • Taha AY, Huot PS, Reza-Lopez S, Prayitno NR, Kang JX, Burnham WM, Ma DW 2008) Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. J Neurochem 105 : 380 388.
    • (2008) J Neurochem , vol.105 , pp. 380-388
    • Taha, A.Y.1    Huot, P.S.2    Reza-Lopez, S.3    Prayitno, N.R.4    Kang, J.X.5    Burnham, W.M.6    Ma, D.W.7
  • 48
    • 0142010520 scopus 로고    scopus 로고
    • Regulation of human delta-6 desaturase gene transcription: Identification of a functional direct repeat-1 element
    • Tang C, Cho HP, Nakamura MT, Clarke SD 2003) Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res 44 : 686 695.
    • (2003) J Lipid Res , vol.44 , pp. 686-695
    • Tang, C.1    Cho, H.P.2    Nakamura, M.T.3    Clarke, S.D.4
  • 49
    • 0037427839 scopus 로고    scopus 로고
    • The effect of the 'classic' ketogenic diet on animal seizure models
    • Thavendiranathan P, Chow C, Cunnane S, McIntyre BW 2003) The effect of the 'classic' ketogenic diet on animal seizure models. Brain Res 959 : 206 213.
    • (2003) Brain Res , vol.959 , pp. 206-213
    • Thavendiranathan, P.1    Chow, C.2    Cunnane, S.3    McIntyre, B.W.4
  • 50
    • 33644625777 scopus 로고    scopus 로고
    • Brain inflammation in epilepsy: Experimental and clinical evidence
    • Vezzani A, Granata T 2005) Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46 : 1724 1743.
    • (2005) Epilepsia , vol.46 , pp. 1724-1743
    • Vezzani, A.1    Granata, T.2
  • 52
    • 0032509704 scopus 로고    scopus 로고
    • Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model
    • Voskuyl RA, Vreugdenhil M, Kang JX, Leaf A 1998) Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 341 : 145 152.
    • (1998) Eur J Pharmacol , vol.341 , pp. 145-152
    • Voskuyl, R.A.1    Vreugdenhil, M.2    Kang, J.X.3    Leaf, A.4
  • 53
    • 0037380056 scopus 로고    scopus 로고
    • In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy - Exploration of GABA levels in a ketogenic diet
    • Wang ZJ, Bergqvist C, Hunter JV, Jin D, Wang DJ, Wehrli S, Zimmerman RA 2003) In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy - exploration of GABA levels in a ketogenic diet. Magn Reson Med 49 : 615 619.
    • (2003) Magn Reson Med , vol.49 , pp. 615-619
    • Wang, Z.J.1    Bergqvist, C.2    Hunter, J.V.3    Jin, D.4    Wang, D.J.5    Wehrli, S.6    Zimmerman, R.A.7
  • 54
    • 36949024511 scopus 로고    scopus 로고
    • The PPAR alpha-humanized mouse: A model to investigate species differences in liver toxicity mediated by PPAR alpha
    • Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez FJ 2008) The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. Toxicol Sci 101 : 132 139.
    • (2008) Toxicol Sci , vol.101 , pp. 132-139
    • Yang, Q.1    Nagano, T.2    Shah, Y.3    Cheung, C.4    Ito, S.5    Gonzalez, F.J.6
  • 55
    • 0028316790 scopus 로고
    • Essential fatty acid preparation (SR-3) raises the seizure threshold in rats
    • Yehuda S, Carasso RL, Mostofsky DI 1994) Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 254 : 193 198.
    • (1994) Eur J Pharmacol , vol.254 , pp. 193-198
    • Yehuda, S.1    Carasso, R.L.2    Mostofsky, D.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.