Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 19, 2011, Pages 5869-5875

  Lietard, Jory ^a   Ittig, Damian ^a   Leumann, Christian J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antisense; Bicyclo DNA; DNA diagnostics; Nucleosides; Oligonucleotides

Indexed keywords

1 [5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 6' [3'' (N FMOC AMINOPROPYL)] AMINO 2' DEOXY 3',5' ETHANO BETA RIBOFURANOSYL]THYMINE 3; 1 [5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 6' [3'' (N FMOC AMINOPROPYL)]AMINO 3' O (2 CYANOETHOXY)DIISOPROPYLAMINOPHOSPHANYL 2' DEOXY 3',5' ETHANO BETA RIBOFURANOSYL]THYMINE 5; 1 [5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 6' [3'' (N FMOC AMINOPROPYL)]TRIFLUOROACETYL AMINO 2' DEOXY 3',5' ETHANO BETA RIBOFURANOSYL]THYMINE 4; 1 [5' O [(4,4' DIMETHOXYTRIPHENYL)METHYL] 6' AMINO 2' DEOXY 3',5' ETHANO BETA RIBOFURANOSYL]THYMINE 2; COMPLEMENTARY DNA; OLIGONUCLEOTIDE; RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DNA MODIFICATION; DRUG DNA BINDING; DRUG MECHANISM; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; EMBRYO; HUMAN; HUMAN CELL; INTERNALIZATION; RESIDUE ANALYSIS; RNA BINDING;

BASE PAIRING; BASE SEQUENCE; CELL LINE; DNA; HUMANS; LYSINE; OLIGODEOXYRIBONUCLEOTIDES; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RNA; THYMIDINE; TRANSITION TEMPERATURE;

EID: 80052952182     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.022     Document Type: Article

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