Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis

Human Immunology

Volumn 73, Issue 8, 2012, Pages 844-851

  Yang, Chin An ^a   Raftery, Martin J ^a   Hamann, Lutz ^a   Guerreiro, Manuel ^a   Grütz, Gerald ^a   Haase, Doreen ^a   Unterwalder, Nadine ^a   Schönrich, Günther ^a   Schumann, Ralf R ^a   Volk, Hans Dieter ^a   Scheibenbogen, Carmen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HERPES LABIALIS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RECURRENT DISEASE;

ADULT; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; HERPES LABIALIS; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; POLY I-C; POLYMORPHISM, SINGLE NUCLEOTIDE; RECURRENCE; TOLL-LIKE RECEPTOR 3;

EID: 84864058577     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2012.04.008     Document Type: Article

References (42)

1. Netea M.G., van der Meer J.W. Immunodeficiency and genetic defects of pattern-recognition receptors. N Engl J Med 2011, 364:60-70.
2. von Bernuth H., Picard C., Jin Z., Pankla R., Xiao H., Ku C.L., et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008, 321:691-696.
3. Ku C.L., von Bernuth H., Picard C., Zhang S.Y., Chang H.H., Yang K., et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med 2007, 204:2407-2422.
4. Agnese D.M., Calvano J.E., Hahm S.J., Coyle S.M., Corbett S.A., Calvano S.E., et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002, 186:1522-1525.
5. Schroder N.W., Schumann R.R. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 2005, 5:156-164.
6. Johnson C.M., Lyle E.A., Omueti K.O., Stepensky V.A., Yegin O., Alpsoy E., et al. Cutting edge: a common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol 2007, 178:7520-7524.
7. Misch E.A., Macdonald M., Ranjit C., Sapkota B.R., Wells R.D., Siddiqui M.R., et al. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis 2008, 2:e231.
8. Brown R.A., Gralewski J.H., Razonable R.R. The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus. Clin Infect Dis 2009, 49:e96-e99.
9. Nahum A., Dadi H., Bates A., Roifman C.M. The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity. J Allergy Clin Immunol 2010, 127:528-531.
10. Gorbea C., Makar K.A., Pauschinger M., Pratt G., Bersola J.L., Varela J., et al. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem 2010, 285:23208-23223.
11. Knipe DM. HP: fields virology. Philadelphia: Lippincott Williams & Wilkins; 2007.
12. Biron C.A., Byron K.S., Sullivan J.L. Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 1989, 320:1731-1735.
13. Orange J.S. Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect 2002, 4:1545-1558.
14. Itzhaki R., Wozniak M. Susceptibility to herpes simplex labialis conferred by the gene encoding apolipoprotein E. J Infect Dis 2008, 198:624-625. [author reply 25-26].
15. Hobbs M.R., Jones B.B., Otterud B.E., Leppert M., Kriesel J.D. Identification of a herpes simplex labialis susceptibility region on human chromosome 21. J Infect Dis 2008, 197:340-346.
16. Sato A., Linehan M.M., Iwasaki A. Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci USA 2006, 103:17343-17348.
17. Casrouge A., Zhang S.Y., Eidenschenk C., Jouanguy E., Puel A., Yang K., et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 2006, 314:308-312.
18. Perez de Diego R., Sancho-Shimizu V., Lorenzo L., Puel A., Plancoulaine S., Picard C., et al. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity 2010, 33:400-411.
19. Zhang S.Y., Jouanguy E., Ugolini S., Smahi A., Elain G., Romero P., et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science 2007, 317:1522-1527.
20. Penack O., Gentilini C., Fischer L., Asemissen A.M., Scheibenbogen C., Thiel E., et al. CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets. Leukemia 2005, 19:835-840.
21. Hamann L., Hamprecht A., Gomma A., Schumann R.R. Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor-2, -4, and -9 genes. J Immunol Methods 2004, 285:281-291.
22. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002, 168:4531-4537.
23. Lauzon N.M., Mian F., MacKenzie R., Ashkar A.A. The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity. Cell Immunol 2006, 241:102-112.
24. Girart M.V., Fuertes M.B., Domaica C.I., Rossi L.E., Zwirner N.W. Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12. J Immunol 2007, 179:3472-3479.
25. MacLeod H., Wetzler L.M. T cell activation by TLRs: a role for TLRs in the adaptive immune response. Sci STKE 2007, 402:pe48.
26. Ranjith-Kumar C.T., Miller W., Sun J., Xiong J., Santos J., Yarbrough I., et al. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem 2007, 282:17696-17705.
27. Poli A., Michel T., Theresine M., Andres E., Hentges F., Zimmer J. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 2009, 126:458-465.
28. Willmann O., Ahmad-Nejad P., Neumaier M., Hennerici M.G., Fatar M. Toll-like receptor 3 immune deficiency may be causative for HSV-2-associated mollaret meningitis. Eur Neurol 2010, 63:249-251.
29. Dhiman N., Ovsyannikova I.G., Vierkant R.A., Ryan J.E., Pankratz V.S., Jacobson R.M., et al. Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. Vaccine 2008, 26:1731-1736.
30. Nahum A., Dadi H., Bates A., Roifman C.M. The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity. J Allergy Clin Immunol 2011, 127:528-531.
31. Alcais A., Abel L., Casanova J.L. Human genetics of infectious diseases: between proof of principle and paradigm. J Clin Invest 2009, 119:2506-2514.
32. Wlasiuk G., Khan S., Switzer W.M., Nachman M.W. A history of recurrent positive selection at the toll-like receptor 5 in primates. Mol Biol Evol 2009, 26:937-949.
33. Sprong T., van Deuren M. Mannose-binding lectin: ancient molecule, interesting future. Clin Infect Dis 2008, 47:517-518.
34. Hoeflich C., Unterwalder N., Schuett S., Schmolke K., Boenisch O., Hammer M., et al. Clinical manifestation of mannose-binding lectin deficiency in adults independent of concomitant immunodeficiency. Hum Immunol 2009, 70:809-812.
35. Hart O.M., Athie-Morales V., O'Connor G.M., Gardiner C.M. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol 2005, 175:1636-1642.
36. Young J.W., Baggers J., Soergel S.A. High-dose UV-B radiation alters human dendritic cell costimulatory activity but does not allow dendritic cells to tolerize T lymphocytes to alloantigen in vitro. Blood 1993, 81:2987-2997.
37. Hara Y., Shiraishi A., Kobayashi T., Kadota Y., Shirakata Y., Hashimoto K., et al. Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections. Mol Vis 2009, 15:937-948.
38. Peri P., Mattila R.K., Kantola H., Broberg E., Karttunen H.S., Waris M., et al. Herpes simplex virus type 1 Us3 gene deletion influences toll-like receptor responses in cultured monocytic cells. Virol J 2008, 5:140.
39. Davey G.M., Wojtasiak M., Proietto A.I., Carbone F.R., Heath W.R., Bedoui S. Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo. J Immunol 2010, 184:2243-2246.
40. Gerosa F., Baldani-Guerra B., Nisii C., Marchesini V., Carra G., Trinchieri G. Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 2002, 195:327-333.
41. Nandakumar S., Woolard S.N., Yuan D., Rouse B.T., Kumaraguru U. Natural killer cells as novel helpers in anti-herpes simplex virus immune response. J Virol 2008, 82:10820-10831.
42. Prehaud C., Megret F., Lafage M., Lafon M. Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol 2005, 79:12893-12904.