ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling

Journal of Molecular Medicine

Volumn 90, Issue 2, 2012, Pages 127-138

  Beharier, Ofer ^a,d   Dror, Shani ^a,d   Levy, Shiri ^a   Kahn, Joy ^a   Mor, Merav ^a,d   Etzion, Sharon ^d   Gitler, Daniel ^a   Katz, Amos ^c,d   Muslin, Anthony J ^b   Moran, Arie ^a   Etzion, Yoram ^d  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BARZILAI MEDICAL CENTER   (Israel)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Cardiomyocyte survival; Extracellular signal regulated kinase; Raf 1 kinase; Reperfusion injury salvage kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN ZNT 1; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DAMAGE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; NONHUMAN; PROTEIN EXPRESSION; RAT; STAINING;

ANIMALS; CATION TRANSPORT PROTEINS; CELL DEATH; CELL LINE; CELL SURVIVAL; ENZYME ACTIVATION; FLAVONOIDS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MYOCYTES, CARDIAC; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; REPERFUSION INJURY; ZINC;

EID: 84857356778     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0845-0     Document Type: Article

References (35)

1. DM Yellon DJ Hausenloy 2007 Myocardial reperfusion injury N Engl J Med 357 1121 1135 10.1056/NEJMra071667 17855673 10.1056/NEJMra071667 1:CAS:528:DC%2BD2sXhtVKgtLzF
2. LM Buja 2005 Myocardial ischemia and reperfusion injury Cardiovasc Pathol 14 170 16009313 10.1016/j.carpath.2005.03.006 1:CAS:528:DC%2BD2MXmt1Wjs7o%3D
3. DJ Hausenloy DM Yellon 2009 Preconditioning and postconditioning: underlying mechanisms and clinical application Atherosclerosis 204 334 341 19081095 10.1016/j.atherosclerosis.2008.10.029 1:CAS:528:DC%2BD1MXmtl2lsLc%3D
4. DJ Hausenloy DM Yellon 2007 Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection Heart Fail Rev 12 217 234 17541822 10.1007/s10741-007-9026-1 1:CAS:528:DC%2BD2sXnvFKntLs%3D
5. EK Iliodromitis A Papalois G Gritsopoulos DT Kremastinos DM Yellon DJ Hausenloy 2009 Remote ischaemic preconditioning and postconditioning and the reperfusion injury salvage kinase pathway Heart 95 13
6. S Philipp SD Critz L Cui V Solodushko MV Cohen JM Downey 2006 Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway Basic Res Cardiol 101 159 167 16283591 10.1007/s00395-005-0566- z 1:CAS:528:DC%2BD28Xjtleqsr4%3D
7. DJ Hausenloy DM Yellon 2009 Cardioprotective growth factors Cardiovasc Res 83 179 194 10.1093/cvr/cvp062 19218286 10.1093/cvr/cvp062 1:CAS:528:DC%2BD1MXnvVOksrc%3D
8. DJ Lips OF Bueno BJ Wilkins NH Purcell RA Kaiser JN Lorenz L Voisin MK Saba-El-Leil S Meloche J Pouyssegur G Pages LJ De Windt PA Doevendans JD Molkentin 2004 MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo Circulation 109 1938 1941 10.1161/01.CIR.0000127126.73759.23 15096454 10.1161/01.CIR.0000127126.73759.23 1:CAS:528:DC%2BD2cXjtFOmt78%3D
9. JJ Bruinsma T Jirakulaporn AJ Muslin K Kornfeld 2002 Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling Dev Cell 2 567 578 12015965 10.1016/S1534-5807(02)00151-X 1:CAS:528:DC%2BD38XktVGjsro%3D
10. T Jirakulaporn AJ Muslin 2004 Cation diffusion facilitator proteins modulate Raf-1 activity J Biol Chem 279 27807 27815 15096503 10.1074/jbc.M401210200 1:CAS:528:DC%2BD2cXkvFGmsr4%3D
11. M Lazarczyk C Pons JA Mendoza P Cassonnet Y Jacob M Favre 2008 Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses J Exp Med 205 35 42 10.1084/jem.20071311 18158319 10.1084/jem.20071311 1:CAS:528: DC%2BD1cXht1ykt70%3D
12. R Palmiter S Findley 1995 Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc EMBO J 14 639 649 7882967 1:CAS:528:DyaK2MXktF2msrg%3D
13. RJ Cousins JP Liuzzi LA Lichten 2006 Mammalian zinc transport, trafficking, and signals J Biol Chem 281 24085 24089 16793761 10.1074/jbc.R600011200 1:CAS:528:DC%2BD28Xot1eru7c%3D
14. S Levy O Beharier Y Etzion M Mor L Buzaglo L Shaltiel LA Gheber J Kahn AJ Muslin A Katz D Gitler A Moran 2009 Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels J Biol Chem 284 32434 32443 19767393 10.1074/jbc.M109.058842 1:CAS:528:DC%2BD1MXhsVSmur%2FP
15. O Beharier Y Etzion A Katz H Friedman N Tenbosh S Zacharish S Bereza U Goshen A Moran 2007 Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling Cell Calcium 42 71 82 17196651 10.1016/j.ceca.2006.11.007 1:CAS:528:DC%2BD2sXlsF2gtbc%3D
16. G Kamalov PA Deshmukh NY Baburyan MS Gandhi PL Johnson RA Ahokas SK Bhattacharya Y Sun IC Gerling KT Weber 2009 Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism J Cardiovasc Pharmacol 53 414 423 10.1097/FJC.0b013e3181a15e77 19333130 10.1097/FJC.0b013e3181a15e77 1:CAS:528:DC%2BD1MXmtVOns7s%3D
17. SM White PE Constantin WC Claycomb 2004 Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function Am J Physiol Heart Circ Physiol 286 H823 H829 14766671 10.1152/ajpheart.00986.2003 1:CAS:528:DC%2BD2cXitlShsrw%3D
18. EM Seymour SY Wu MA Kovach MA Romano JR Traynor WC Claycomb SF Bolling 2003 HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning J Surg Res 114 187 194 S0022480403002488 14559445 10.1016/S0022-4804(03)00248-8 1:CAS:528:DC%2BD3sXotVCiurc%3D
19. HT Facundo JG de Paula AJ Kowaltowski 2005 Mitochondrial ATP-sensitive K∈+∈channels prevent oxidative stress, permeability transition and cell death J Bioenerg Biomembr 37 75 82 10.1007/s10863-005-4130-1 15906152 10.1007/s10863-005-4130-1 1:CAS:528:DC%2BD2MXktlKkt7o%3D
20. M Ruiz-Meana D Garcia-Dorado E Miro-Casas A Abellan J Soler-Soler 2006 Mitochondrial Ca2+ uptake during simulated ischemia does not affect permeability transition pore opening upon simulated reperfusion Cardiovasc Res 71 715 724 10.1016/j.cardiores.2006.06.019 16860295 10.1016/j.cardiores.2006.06.019 1:CAS:528:DC%2BD28XotVCqsLo%3D
21. M Ljubkovic J Marinovic A Fuchs ZJ Bosnjak M Bienengraeber 2006 Targeted expression of Kir6.2 in mitochondria confers protection against hypoxic stress J Physiol 577 17 29 10.1113/jphysiol.2006.118299 16959852 10.1113/jphysiol.2006. 118299 1:CAS:528:DC%2BD28Xht1yqsL%2FO
22. RA Cavalheiro RM Marin SA Rocco FM Cerqueira CC da Silva R Rittner AJ Kowaltowski AE Vercesi KG Franchini RF Castilho 2010 Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation PLoS One 5 e10666 10.1371/journal.pone. 0010666 20498724 10.1371/journal.pone.0010666
23. S Yitzhaki C Huang W Liu Y Lee AB Gustafsson RM Mentzer Jr RA Gottlieb 2009 Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA Basic Res Cardiol 104 157 167 10.1007/s00395-009-0006-6 19242639 10.1007/s00395-009-0006-6 1:CAS:528:DC%2BD1MXivVSis7c%3D
24. RJ McMahon RJ Cousins 1998 Regulation of the zinc transporter ZnT-1 by dietary zinc PNAS 95 4841 4846 9560190 10.1073/pnas.95.9.4841 1:CAS:528:DyaK1cXivVyqurw%3D
25. G Heusch 2009 No risk, no cardioprotection? A critical perspective Cardiovasc Res 84 173 175 10.1093/cvr/cvp298 19713282 10.1093/cvr/cvp298 1:CAS:528:DC%2BD1MXht1OrtLvK
26. A Skyschally P van Caster K Boengler P Gres J Musiolik D Schilawa R Schulz G Heusch 2009 Ischemic postconditioning in pigs: no causal role for RISK activation Circ Res 104 15 18 10.1161/circresaha.108.186429 19038864 10.1161/CIRCRESAHA.108.186429 1:CAS:528:DC%2BD1cXhsFSmt7%2FJ
27. E Murphy C Steenbergen 2008 Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury Physiol Rev 88 581 609 10.1152/physrev. 00024.2007 18391174 10.1152/physrev.00024.2007 1:CAS:528:DC%2BD1cXls1KhsL8%3D
28. R Ramaraj MB Forman EK Jackson CJ Lowenstein B Ibanez G Cimmino JJ Badimon PG Korantzopoulos JA Goudevenos DM Yellon DJ Hausenloy 2007 Myocardial reperfusion injury N Engl J Med 357 2408 2410 10.1056/NEJMc072913 18057349 10.1056/NEJMc072913 1:CAS:528:DC%2BD2sXhsVWhtbzM
29. SC Armstrong 2004 Protein kinase activation and myocardial ischemia/reperfusion injury Cardiovasc Res 61 427 436 10.1016/j.cardiores.2003. 09.031 14962474 10.1016/j.cardiores.2003.09.031 1:CAS:528:DC%2BD2cXhtFWms7c%3D
30. PC Beguin E Belaidi D Godin-Ribuot P Levy C Ribuot 2007 Intermittent hypoxia-induced delayed cardioprotection is mediated by PKC and triggered by p38 MAP kinase and Erk1/2 J Mol Cell Cardiol 42 343 351 10.1016/j.yjmcc.2006.11.008 17188294 10.1016/j.yjmcc.2006.11.008 1:CAS:528:DC%2BD2sXhtVKlsrk%3D
31. K Przyklenk K Hata RA Kloner 1997 Is calcium a mediator of infarct size reduction with preconditioning in canine myocardium? Circulation 96 1305 1312 9286963 1:CAS:528:DyaK2sXlvVaqs7o%3D
32. H Miyawaki X Zhou M Ashraf 1996 Calcium preconditioning elicits strong protection against ischemic injury via protein kinase C signaling pathway Circ Res 79 137 146 8925561 1:CAS:528:DyaK28XjvVagurs%3D
33. BS Cain DR Meldrum JC Cleveland X Meng A Banerjee AH Harken 1999 Clinical L-type Ca(2+) channel blockade prevents ischemic preconditioning of human myocardium J Mol Cell Cardiol 31 2191 2197 10640446 10.1006/jmcc.1999.1039 1:CAS:528:DC%2BD3cXkvVSjsg%3D%3D
34. D Schulman DS Latchman DM Yellon 2002 Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway Am J Physiol Heart Circ Physiol 283 H1481 H1488 10.1152/ajpheart.01089.2001 12234800 1:CAS:528:DC%2BD38XotVKit7s%3D
35. BK Brar AK Jonassen A Stephanou G Santilli J Railson RA Knight DM Yellon DS Latchman 2000 Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway J Biol Chem 275 8508 8514 10722688 10.1074/jbc.275.12. 8508 1:CAS:528:DC%2BD3cXit1enurc%3D