Generation and characterization of mice lacking the zinc uptake transporter ZIP3

Molecular and Cellular Biology

Volumn 25, Issue 13, 2005, Pages 5607-5615

  Dufner Beattie, Jodi ^a   Huang, Zhixin L ^a   Geiser, Jim ^a   Xu, Wenhao ^a   Andrews, Glen K ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN; PROTEIN ZIP3; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; BLASTOCYST; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENETIC CONSERVATION; HOMEOSTASIS; INNER CELL MASS; ION TRANSPORT; KNOCKOUT MOUSE; MAMMAL; MOUSE; NEURAL TUBE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; T LYMPHOCYTE; ZIP3 GENE;

ANIMALS; ANIMALS, NEWBORN; BLASTOCYST; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; CROSSES, GENETIC; ELECTROPORATION; EMBRYONIC DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PREGNANCY; STEM CELLS; TISSUE DISTRIBUTION; ZINC;

MAMMALIA;

EID: 20744459726     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.13.5607-5615.2005     Document Type: Article

References (49)

1. Andrews, G. K. 1990. Regulation of metallothionein gene expression. Prog. Food Nutr. Sci. 14:193-258.
2. Andrews, G. K., and J. Geiser. 1999. Expression of metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency. J. Nutr. 129:1643-1648.
3. Andrews, G. K., H. Wang, S. K. Dey, and R. D. Palmiter. 2004. The mouse zinc transporter 1 gene provides an essential function during early embryonic development. Genesis 40:74-81.
4. Apgar, J. 1985. Zinc and reproduction. Annu. Rev. Nutr. 5:43-68.
5. Baudon, J. J., J. L. Fontaine, M. Larregue, G. Feldmann, and R. Laplane. 1978. Acrodermatitis enteropathica. Anatomo-clinical study of 2 familial cases treated with zinc sulfate. Arch. Fr. Pediatr. 35:63-73.
6. Berg, J. M., and Y. G. Shi. 1996. The galvanization of biology: A growing appreciation for the roles of zinc. Science 271:1081-1085.
7. Bohane, T. D., E. Cutz, J. R. Hamilton, and D. G. Gall. 1977. Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies. Gastroenterology 73:587-592.
8. Cole, T. B., C. A. Robbins, H. J. Wenzel, P. A. Schwartzkroin, and R. D. Palmiter. 2000. Seizures and neuronal damage in mice lacking vesicular zinc. Epilepsy Res. 39:153-169.
9. Cook Mills, J. M., and P. J. Fraker. 1993. Functional capacity of the residual lymphocytes from zinc-deficient adult mice. Br. J. Nutr. 69:835-848.
10. Coyle, P., J. C. Philcox, L. C. Carey, and A. M. Rofe. 2002. Metallothionein: the multipurpose protein. Cell. Mol. Life Sci. 59:627-647.
11. Dalton, T. P., K. Fu, R. D. Palmiter, and G. K. Andrews. 1996. Transgenic mice that over-express metallothionein-I resist dietary zinc deficiency. J. Nutr. 126:825-833.
12. Dalton, T. P., R. D. Palmiter, and G. K. Andrews. 1994. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res. 22:5016-5023.
13. Dufner-Beattie, J., Y. M. Kuo, J. Gitschier, and G. K. Andrews. 2004. The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc-regulation of the zinc transporters ZIP4 and ZIP5. J. Biol. Chem. 279:49082-49090.
14. Dufner-Beattie, J., S. J. Langmade, F. Wang, D. Eide, and G. K. Andrews. 2003. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem. 278:50142-50150.
15. Dufner-Beattie, J., F. Wang, Y. M. Kuo, J. Gitschier, D. Eide, and G. K. Andrews. 2003. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. J. Biol. Chem. 278:33474-33481.
16. Eide, D. 1997. Molecular biology of iron and zinc uptake in eukaryotes. Curr. Opin. Cell Biol. 9:573-577.
17. Fraker, P. J., and L. E. King. 2004. Reprogramming of the immune system during zinc deficiency. Annu. Rev. Nutr. 24:277-298.
18. Fraker, P. J., L. E. King, T. Laakko, and T. L. Vollmer. The dynamic link between the integrity of the immune system and zinc status. J. Nutr. 130:1399S-1406S, 2000.
19. Godwin, A. R., H. S. Stadler, K. Nakamura, and M. R. Capecchi. 1998. Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc. Natl. Acad. Sci. USA 95:13042-13047.
20. Guerinot, M. L. 2000. The ZIP family of metal transporters. Biochim. Biophys. Acta 1465:190-198.
21. Hambidge, M., and N. F. Krebs. 2001. Interrelationships of key variables of human zinc homeostasis: Relevance to dietary zinc requirements. Annu. Rev. Nutr. 21:429-452.
22. Harris, E. D. 2002. Cellular transporters for zinc. Nutr. Rev. 60:121-124.
23. Huang, L., C. P. Kirschke, and J. Gitschier. 2002. Functional characterization of a novel mammalian zinc transporter, ZnT6. J. Biol. Chem. 277:26389-26395.
24. Huang, L. P., and J. Gitschier. 1997. A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat. Genet. 17:292-297.
25. Huang, Z. L., and P. J. Fraker. 2003. Chronic consumption of a moderately low protein diet does not alter hematopoietic processes in young adult mice. J. Nutr. 133:1403-1408.
26. Inoue, K., K. Matsuda, M. Itoh, H. Kawaguchi, H. Tomoike, T. Aoyagi, R. Nagai, M. Hori, Y. Nakamura, and T. Tanaka. 2002. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Hum. Mol. Genet. 11:1775-1784.
27. Kambe, T., Y. Yamaguchi-Iwai, R. Sasaki, and M. Nagao. 2004. Overview of mammalian zinc transporters. Cell. Mol. Life Sci. 61:49-68.
28. Kelleher, S. L., and B. Lonnerdal. 2003. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J. Nutr. 133:3378-3385.
29. Kelleher, S. L., and B. Lonnerdal. 2005. Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin. Am. J. Physiol. Cell. Physiol. 288:1042-1047.
30. 2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J. Biol. Chem. 279:4523-4530.
31. King, J. C., D. M. Shames, and L. R. Woodhouse. 2000. Zinc homeostasis in humans. J. Nutr. 130(Suppl.):1360S-1366S.
32. King, L. E., and P. J. Fraker. 2002. Zinc deficiency in mice alters myelopoiesis and hematopoiesis. J. Nutr. 132:3301-3307.
33. Krieger, I., G. W. Evans, and P. S. Zelkowitz. 1982. Zinc dependency as a cause of chronic diarrhea in variant acrodermatitis enteropathica. Pediatrics 69:773-777.
34. Krishna, S. S., I. Majumdar, and N. V. Grishin. 2003. Structural classification of zinc fingers. Nucleic Acids Res. 31:532-550.
35. Lamar, E. E., and E. Palmer. 1984. Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains. Cell 37:171-177.
36. Langmade, S. J., R. Ravindra, P. J. Daniels, and G. K. Andrews. 2000. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J. Biol. Chem. 275:34803-34809.
37. Larregue, M., J. J. Baudon, J. L. Fontaine, G. Feldmann, and R. Laplane. 1977. Acrodermatitis enteropathica: zinc sulfate therapy. Ann. Dermatol. Venereol. 104:737-744.
38. Lee, D. K., J. Geiser, J. Dufner-Beattie, and G. K. Andrews. 2003. Pancreatic metallothionein-1 may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice. J. Nutr. 133:45-50.
39. Liuzzi, J. P., R. K. Blanchard, and R. J. Cousins. 2001. Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. J. Nutr. 131:46-52.
40. Liuzzi, J. P., and R. J. Cousins. 2004. Mammalian zinc transporters. Annu. Rev. Nutr. 24:151-172.
41. Mathews, W. R., F. Wang, D. J. Eide, and M. Van Doren. 2005. Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins. J. Biol. Chem. 280:787-795.
42. McClain, C. J. 1990. The pancreas and zinc homeostasis. J. Lab. Clin. Med. 116:275-276.
43. Ohlsson, A. 1981. Acrodermatitis enteropathica Reversibility of cerebral atrophy with zinc therapy. Acta Paediatr. Scand. 70:269-273.
44. Taylor, K. M., and R. I. Nicholson. 2003. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta 1611:16-30.
45. Thomas, K. R., and M. R. Capecchi. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512.
46. Vallee, B. L., and D. S. Auld. 1990. Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry 29:5647-5659.
47. Wang, F., J. Dufner-Beattie, B. E. Kim, M. J. Petris, G. Andrews, and D. J. Eide. 2004. Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters. J. Biol. Chem. 279:24631-24639.
48. Wang, F., B. E. Kim, M. J. Petris, and D. J. Eide. 2004. The mouse ZIP5 protein functions as a zinc transporter and localizes to the basolateral surface of polarized cells. J. Biol. Chem. 279:51433-51441.
49. Yamashita, S., C. Miyagi, T. Fukada, N. Kagara, Y. S. Che, and T. Hirano. 2004. Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature 429:298-302.