Aurora kinase B/C inhibition impairs malignant glioma growth in vivo

Journal of Neuro-Oncology

Volumn 108, Issue 3, 2012, Pages 349-360

  Diaz, Roberto Jose ^a,b   Golbourn, Brian ^a   Shekarforoush, Maryam ^a   Smith, Christian A ^a   Rutka, James T ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aurora kinase; Cell cycle; Glioblastoma; Molecular therapy; Tumor biology

Indexed keywords

AURORA B KINASE; AURORA C KINASE; AZD 1152 HQPA; BARASERTIB; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOPHOSPHORYLATION; BRAIN TISSUE; CANCER INHIBITION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; DRUG DOSE COMPARISON; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIOBLASTOMA; GLIOMA CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOSIS INHIBITION; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PROTEIN EXPRESSION; SURVIVAL TIME; TREATMENT DURATION; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; ASTROCYTES; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GLIOMA; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MICE; MICE, NUDE; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RNA, MESSENGER;

EID: 84864043374     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-012-0835-2     Document Type: Article

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