-
1
-
-
34548822673
-
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo
-
10.1182/blood-2007-02-073700, 17495131
-
Yang J, Ikezoe T, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y, Komatsu N, Bandobashi K, Togitani K, Koeffler HP, et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 2007, 110:2034-2040. 10.1182/blood-2007-02-073700, 17495131.
-
(2007)
Blood
, vol.110
, pp. 2034-2040
-
-
Yang, J.1
Ikezoe, T.2
Nishioka, C.3
Tasaka, T.4
Taniguchi, A.5
Kuwayama, Y.6
Komatsu, N.7
Bandobashi, K.8
Togitani, K.9
Koeffler, H.P.10
-
2
-
-
44349168457
-
Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152
-
10.1038/sj.onc.1210990, 18084327
-
Tao Y, Zhang P, Girdler F, Frascogna V, Castedo M, Bourhis J, Kroemer G, Deutsch E. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 2008, 27:3244-3255. 10.1038/sj.onc.1210990, 18084327.
-
(2008)
Oncogene
, vol.27
, pp. 3244-3255
-
-
Tao, Y.1
Zhang, P.2
Girdler, F.3
Frascogna, V.4
Castedo, M.5
Bourhis, J.6
Kroemer, G.7
Deutsch, E.8
-
3
-
-
0038341158
-
The Aurora kinases: role in cell transformation and tumorigenesis
-
10.1023/A:1023789416385, 12884918
-
Katayama H, Brinkley WR, Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 2003, 22:451-464. 10.1023/A:1023789416385, 12884918.
-
(2003)
Cancer Metastasis Rev
, vol.22
, pp. 451-464
-
-
Katayama, H.1
Brinkley, W.R.2
Sen, S.3
-
4
-
-
33846988313
-
Roles of Aurora kinases in mitosis and tumorigenesis
-
10.1158/1541-7786.MCR-06-0208, 17259342
-
Fu J, Bian M, Jiang Q, Zhang C. Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 2007, 5:1-10. 10.1158/1541-7786.MCR-06-0208, 17259342.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 1-10
-
-
Fu, J.1
Bian, M.2
Jiang, Q.3
Zhang, C.4
-
5
-
-
6344270057
-
Aurora kinases in spindle assembly and chromosome segregation
-
10.1016/j.yexcr.2004.08.016, 15501446
-
Ducat D, Zheng Y. Aurora kinases in spindle assembly and chromosome segregation. Exp Cell Res 2004, 301:60-67. 10.1016/j.yexcr.2004.08.016, 15501446.
-
(2004)
Exp Cell Res
, vol.301
, pp. 60-67
-
-
Ducat, D.1
Zheng, Y.2
-
6
-
-
2342528439
-
The survivin/Aurora B complex: its role in coordinating tension and attachment
-
Lens SM, Medema RH. The survivin/Aurora B complex: its role in coordinating tension and attachment. Cell Cycle 2003, 2:507-510.
-
(2003)
Cell Cycle
, vol.2
, pp. 507-510
-
-
Lens, S.M.1
Medema, R.H.2
-
7
-
-
34250739960
-
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis
-
10.1158/1078-0432.CCR-06-2979, 17575233
-
Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C, Foster JR, Brady MC, Bigley A, Brown E, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res 2007, 13:3682-3688. 10.1158/1078-0432.CCR-06-2979, 17575233.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3682-3688
-
-
Wilkinson, R.W.1
Odedra, R.2
Heaton, S.P.3
Wedge, S.R.4
Keen, N.J.5
Crafter, C.6
Foster, J.R.7
Brady, M.C.8
Bigley, A.9
Brown, E.10
-
8
-
-
0034604354
-
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
-
10.1016/S0092-8674(00)00034-9, 10975519
-
Hsu JY, Sun ZW, Li X, Reuben M, Tatchell K, Bishop DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, et al. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 2000, 102:279-291. 10.1016/S0092-8674(00)00034-9, 10975519.
-
(2000)
Cell
, vol.102
, pp. 279-291
-
-
Hsu, J.Y.1
Sun, Z.W.2
Li, X.3
Reuben, M.4
Tatchell, K.5
Bishop, D.K.6
Grushcow, J.M.7
Brame, C.J.8
Caldwell, J.A.9
Hunt, D.F.10
-
9
-
-
35848971221
-
The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions
-
10.1091/mbc.E07-04-0328, 2043551, 17699588
-
Vader G, Cruijsen CW, van Harn T, Vromans MJ, Medema RH, Lens SM. The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions. Mol Biol Cell 2007, 18:4553-4564. 10.1091/mbc.E07-04-0328, 2043551, 17699588.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4553-4564
-
-
Vader, G.1
Cruijsen, C.W.2
van Harn, T.3
Vromans, M.J.4
Medema, R.H.5
Lens, S.M.6
-
10
-
-
38349108184
-
The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma
-
10.1111/j.1365-2141.2007.06913.x, 18076711
-
Evans RP, Naber C, Steffler T, Checkland T, Maxwell CA, Keats JJ, Belch AR, Pilarski LM, Lai R, Reiman T. The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma. Br J Haematol 2008, 140:295-302. 10.1111/j.1365-2141.2007.06913.x, 18076711.
-
(2008)
Br J Haematol
, vol.140
, pp. 295-302
-
-
Evans, R.P.1
Naber, C.2
Steffler, T.3
Checkland, T.4
Maxwell, C.A.5
Keats, J.J.6
Belch, A.R.7
Pilarski, L.M.8
Lai, R.9
Reiman, T.10
-
11
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
-
10.1083/jcb.200208091, 2172902, 12719470
-
Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 2003, 161:267-280. 10.1083/jcb.200208091, 2172902, 12719470.
-
(2003)
J Cell Biol
, vol.161
, pp. 267-280
-
-
Ditchfield, C.1
Johnson, V.L.2
Tighe, A.3
Ellston, R.4
Haworth, C.5
Johnson, T.6
Mortlock, A.7
Keen, N.8
Taylor, S.S.9
-
12
-
-
10344236486
-
Aurora-kinase inhibitors as anticancer agents
-
10.1038/nrc1502, 15573114
-
Keen N, Taylor S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 2004, 4:927-936. 10.1038/nrc1502, 15573114.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 927-936
-
-
Keen, N.1
Taylor, S.2
-
13
-
-
0033135640
-
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast
-
Tanaka T, Kimura M, Matsunaga K, Fukada D, Mori H, Okano Y. Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res 1999, 59:2041-2044.
-
(1999)
Cancer Res
, vol.59
, pp. 2041-2044
-
-
Tanaka, T.1
Kimura, M.2
Matsunaga, K.3
Fukada, D.4
Mori, H.5
Okano, Y.6
-
14
-
-
51649095478
-
Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer
-
10.1158/1078-0432.CCR-07-5268, 18628459
-
Nadler Y, Camp RL, Schwartz C, Rimm DL, Kluger HM, Kluger Y. Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer. Clin Cancer Res 2008, 14:4455-4462. 10.1158/1078-0432.CCR-07-5268, 18628459.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4455-4462
-
-
Nadler, Y.1
Camp, R.L.2
Schwartz, C.3
Rimm, D.L.4
Kluger, H.M.5
Kluger, Y.6
-
15
-
-
44949248282
-
Aurora A: target invalidated?
-
10.1016/j.chembiol.2008.06.002, 18559262
-
Cochran AG. Aurora A: target invalidated?. Chem Biol 2008, 15:525-526. 10.1016/j.chembiol.2008.06.002, 18559262.
-
(2008)
Chem Biol
, vol.15
, pp. 525-526
-
-
Cochran, A.G.1
-
16
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
10.1093/emboj/17.11.3052, 1170645, 9606188
-
Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Embo J 1998, 17:3052-3065. 10.1093/emboj/17.11.3052, 1170645, 9606188.
-
(1998)
Embo J
, vol.17
, pp. 3052-3065
-
-
Bischoff, J.R.1
Anderson, L.2
Zhu, Y.3
Mossie, K.4
Ng, L.5
Souza, B.6
Schryver, B.7
Flanagan, P.8
Clairvoyant, F.9
Ginther, C.10
-
17
-
-
44949157910
-
Molecular basis of drug resistance in aurora kinases
-
10.1016/j.chembiol.2008.04.013, 18559266
-
Girdler F, Sessa F, Patercoli S, Villa F, Musacchio A, Taylor S. Molecular basis of drug resistance in aurora kinases. Chem Biol 2008, 15:552-562. 10.1016/j.chembiol.2008.04.013, 18559266.
-
(2008)
Chem Biol
, vol.15
, pp. 552-562
-
-
Girdler, F.1
Sessa, F.2
Patercoli, S.3
Villa, F.4
Musacchio, A.5
Taylor, S.6
-
18
-
-
34247603906
-
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase
-
10.1021/jm061335f, 17373783
-
Mortlock AA, Foote KM, Heron NM, Jung FH, Pasquet G, Lohmann JJ, Warin N, Renaud F, De Savi C, Roberts NJ, et al. Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem 2007, 50:2213-2224. 10.1021/jm061335f, 17373783.
-
(2007)
J Med Chem
, vol.50
, pp. 2213-2224
-
-
Mortlock, A.A.1
Foote, K.M.2
Heron, N.M.3
Jung, F.H.4
Pasquet, G.5
Lohmann, J.J.6
Warin, N.7
Renaud, F.8
De Savi, C.9
Roberts, N.J.10
-
19
-
-
0034725698
-
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression
-
10.1074/jbc.M905616199, 10767298
-
Laronga C, Yang HY, Neal C, Lee MH. Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 2000, 275:23106-23112. 10.1074/jbc.M905616199, 10767298.
-
(2000)
J Biol Chem
, vol.275
, pp. 23106-23112
-
-
Laronga, C.1
Yang, H.Y.2
Neal, C.3
Lee, M.H.4
-
20
-
-
33746867442
-
Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo
-
10.1158/0008-5472.CAN-05-3555, 16849573
-
Jerome L, Alami N, Belanger S, Page V, Yu Q, Paterson J, Shiry L, Pegram M, Leyland-Jones B. Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo. Cancer Res 2006, 66:7245-7252. 10.1158/0008-5472.CAN-05-3555, 16849573.
-
(2006)
Cancer Res
, vol.66
, pp. 7245-7252
-
-
Jerome, L.1
Alami, N.2
Belanger, S.3
Page, V.4
Yu, Q.5
Paterson, J.6
Shiry, L.7
Pegram, M.8
Leyland-Jones, B.9
-
21
-
-
11144356956
-
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
-
10.1038/nm969, 14702633
-
Wang LH, Yang XY, Zhang X, Mihalic K, Fan YX, Xiao W, Howard OM, Appella E, Maynard AT, Farrar WL. Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med 2004, 10:40-47. 10.1038/nm969, 14702633.
-
(2004)
Nat Med
, vol.10
, pp. 40-47
-
-
Wang, L.H.1
Yang, X.Y.2
Zhang, X.3
Mihalic, K.4
Fan, Y.X.5
Xiao, W.6
Howard, O.M.7
Appella, E.8
Maynard, A.T.9
Farrar, W.L.10
-
22
-
-
0036158780
-
Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation
-
10.1046/j.1356-9597.2001.00498.x, 11856369
-
Goto H, Yasui Y, Nigg EA, Inagaki M. Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells 2002, 7:11-17. 10.1046/j.1356-9597.2001.00498.x, 11856369.
-
(2002)
Genes Cells
, vol.7
, pp. 11-17
-
-
Goto, H.1
Yasui, Y.2
Nigg, E.A.3
Inagaki, M.4
-
23
-
-
0033515426
-
Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
-
10.1016/S0092-8674(00)80718-7, 10199406
-
Wei Y, Yu L, Bowen J, Gorovsky MA, Allis CD. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 1999, 97:99-109. 10.1016/S0092-8674(00)80718-7, 10199406.
-
(1999)
Cell
, vol.97
, pp. 99-109
-
-
Wei, Y.1
Yu, L.2
Bowen, J.3
Gorovsky, M.A.4
Allis, C.D.5
-
24
-
-
28844475262
-
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin
-
10.1038/nature04254, 16222244
-
Hirota T, Lipp JJ, Toh BH, Peters JM. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 2005, 438:1176-1180. 10.1038/nature04254, 16222244.
-
(2005)
Nature
, vol.438
, pp. 1176-1180
-
-
Hirota, T.1
Lipp, J.J.2
Toh, B.H.3
Peters, J.M.4
-
25
-
-
11144354860
-
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis
-
10.1074/jbc.M311128200, 14722118
-
Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, Furukawa K, Takahashi T, Izawa I, Inagaki M. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem 2004, 279:12997-13003. 10.1074/jbc.M311128200, 14722118.
-
(2004)
J Biol Chem
, vol.279
, pp. 12997-13003
-
-
Yasui, Y.1
Urano, T.2
Kawajiri, A.3
Nagata, K.4
Tatsuka, M.5
Saya, H.6
Furukawa, K.7
Takahashi, T.8
Izawa, I.9
Inagaki, M.10
-
26
-
-
3843083029
-
Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells
-
10.1016/j.surg.2004.05.022, 15300212
-
McKenzie T, Liu Y, Fanale M, Swisher SG, Chada S, Hunt KK. Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells. Surgery 2004, 136:437-442. 10.1016/j.surg.2004.05.022, 15300212.
-
(2004)
Surgery
, vol.136
, pp. 437-442
-
-
McKenzie, T.1
Liu, Y.2
Fanale, M.3
Swisher, S.G.4
Chada, S.5
Hunt, K.K.6
-
27
-
-
1842478456
-
Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fraction
-
10.1158/1078-0432.CCR-03-0244, 15073131
-
Warburton C, Dragowska WH, Gelmon K, Chia S, Yan H, Masin D, Denyssevych T, Wallis AE, Bally MB. Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fraction. Clin Cancer Res 2004, 10:2512-2524. 10.1158/1078-0432.CCR-03-0244, 15073131.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2512-2524
-
-
Warburton, C.1
Dragowska, W.H.2
Gelmon, K.3
Chia, S.4
Yan, H.5
Masin, D.6
Denyssevych, T.7
Wallis, A.E.8
Bally, M.B.9
-
28
-
-
0021958425
-
Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice
-
Osborne CK, Hobbs K, Clark GM. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res 1985, 45:584-590.
-
(1985)
Cancer Res
, vol.45
, pp. 584-590
-
-
Osborne, C.K.1
Hobbs, K.2
Clark, G.M.3
|