Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts

Journal of Organic Chemistry

Volumn 77, Issue 14, 2012, Pages 5982-5992

  Kenis, Sara ^a   D'Hooghe, Matthias ^a   Verniest, Guido ^a,c   Dang Thi, Tuyet Anh ^b   Pham The, Chinh ^b   Van Nguyen, Tuyen ^b   De Kimpe, Norbert ^a  

^a GHENT UNIVERSITY   (Belgium)

^b INSTITUTE OF CHEMISTRY   (Viet Nam)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AZA-HETEROCYCLES; AZETIDINES; ELECTRON WITHDRAWING GROUP; HYDRIDE REDUCTION; QUATERNIZATION; REGIOSPECIFIC; RING CLOSURES; RING OPENING; TRIFLUOROMETHYL;

SULFUR;

ORGANIC COMPOUNDS;

1 (2 CHLOROBENZYL) 2 (TRIFLUOROMETHYL)AZETIDINE; 1 (2 PHENYLETHYL) 2 (TRIFLUOROMETHYL)AZETIDINE; 1 (3 METHOXYBENZYL) 2 (TRIFLUOROMETHYL)AZETIDINE; 1 (4 CHLOROBENZYL) 2 (TRIFLUOROMETHYL)AZETIDINE; 1 (4 METHOXYBENZYL) 2 (TRIFLUOROMETHYL)AZETIDINE; 1 (4 METHYLBENZYL) 2 (TRIFLUOROMETHYL)AZETIDINE; 1 BENZYL 2 (TRIFLUOROMETHYL)AZETIDINE; 4,4,4 TRIFLUOROACETOACETIC ACID ETHYL ESTER; ACETOACETIC ACID; ALPHA(TRIFLUOROMETHYL)AMINE DERIVATIVE; AMINE; AZETIDINE; AZETIDINE DERIVATIVE; CARBON; HALOGEN; NITROGEN; NUCLEOPHILE; OXYGEN; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; RING OPENING; SYNTHESIS;

AMINES; AZETIDINES; MOLECULAR STRUCTURE; SALTS; STEREOISOMERISM;

EID: 84864027422     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300694y     Document Type: Article

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