Cot Kinase Promotes Ca2+ Oscillation/Calcineurin-Independent Osteoclastogenesis by Stabilizing nfatc1 Protein

Molecular and Cellular Biology

Volumn 32, Issue 14, 2012, Pages 2954-2963

  Kuroda, Yukiko ^a,b   Hisatsune, Chihiro ^b   Mizutani, Akihiro ^b,c   Ogawa, Naoko ^b   Matsuo, Koichi ^a   Mikoshiba, Katsuhiko ^b,d  

^a KEIO UNIVERSITY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM ION; COT KINASE; NUCLEAR FACTOR OF ACTIVATED T CELLS C1; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL INTERACTION; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN STABILITY; TUMOR GROWTH;

ANIMALS; BASE SEQUENCE; BONE RESORPTION; CALCINEURIN; CALCIUM SIGNALING; CELL COMMUNICATION; CELL DIFFERENTIATION; DNA PRIMERS; MAP KINASE KINASE KINASES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; NFATC TRANSCRIPTION FACTORS; OSTEOBLASTS; OSTEOCLASTS; PHOSPHORYLATION; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS; RANK LIGAND; RECOMBINANT PROTEINS;

EID: 84864011437     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05611-11     Document Type: Article

References (42)

1. Ballester A, Velasco A, Tobena R, Alemany S. 1998. Cot kinase activates tumor necrosis factor-α gene expression in a cyclosporin A-resistant manner. J. Biol. Chem. 273:14099-14106.
2. Belich MP, Salmeron A, Johnston LH, Ley SC. 1999. TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105. Nature 397:363-368.
3. Carninci P, et al. 2005. The transcriptional landscape of the mammalian genome. Science 309:1559-1563.
4. Ceci JD, et al. 1997. Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev. 11:688-700.
5. Chiariello M, Marinissen MJ, Gutkind JS. 2000. Multiple mitogenactivated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol. Cell. Biol. 20:1747-1758.
6. Crotti TN, et al. 2006. NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation. Gene 372:92-102.
7. de Gregorio R, Iniguez MA, Fresno M, Alemany S. 2001. Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells. J. Biol. Chem. 276:27003-27009.
8. Dumitru CD, et al. 2000. TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103:1071-1083.
9. Futatsugi A, et al. 2005. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309:2232-2234.
10. Hirata K, et al. 2010. Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes. Biol. Pharm. Bull. 33:133-137.
11. Hoey T, Sun YL, Williamson K, Xu X. 1995. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2:461-472.
12. Hogan PG, Chen L, Nardone J, Rao A. 2003. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17:2205-2232.
13. Kikuchi T, et al. 2003. Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts. J. Dent. Res. 82:546-550.
14. Kim K, Kim JH, Youn BU, Jin HM, Kim N. 2010. Pim-1 regulates RANKL-induced osteoclastogenesis via NF-κB activation and NFATc1 induction. J. Immunol. 185:7460-7466.
15. Kim K, Lee SH, Ha Kim J, Choi Y, Kim N. 2008. NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cellspecific transmembrane protein (DC-STAMP). Mol. Endocrinol. 22:176-185.
16. Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K. 2008. Osteoblasts induce Ca2_ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc. Natl. Acad. Sci. U. S. A. 105:8643-8648.
17. Lee SH, et al. 2006. v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat. Med. 12: 1403-1409.
18. Lin X, Cunningham ET, Jr, Mu Y, Geleziunas R, Greene WC. 1999. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity 10:271-280.
19. Liu J, et al. 2009. Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis. J. Biol. Chem. 284:12512-12523.
20. Mancini M, Toker A. 2009. NFAT proteins: emerging roles in cancer progression. Nat. Rev. Cancer 9:810-820.
21. Matsumoto M, et al. 2004. Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU. 1. J. Biol. Chem. 279:45969-45979.
22. Matsuo K, et al. 2004. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J. Biol. Chem. 279:26475-26480.
23. Matsuo K, Irie N. 2008. Osteoclast-osteoblast communication. Arch. Biochem. Biophys. 473:201-209.
24. Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T. 1991. Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. Mol. Cell. Biol. 11:4088-4096.
25. Neal JW, Clipstone NA. 2001. Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc. J. Biol. Chem. 276:3666-3673.
26. Okamura H, et al. 2000. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol. Cell 6:539-550.
27. Parfitt AM, et al. 1987. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2:595-610.
28. Patriotis C, Makris A, Chernoff J, Tsichlis PN. 1994. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc. Natl. Acad. Sci. U. S. A. 91:9755-9759.
29. Rainio EM, Sandholm J, Koskinen PJ. 2002. Cutting edge: transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase. J. Immunol. 168:1524-1527.
30. Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC. 2007. Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol. Cell. Biol. 27:7355-7364.
31. Ruff VA, Leach KL. 1995. Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. J. Biol. Chem. 270:22602-22607.
32. Salmeron A, et al. 1996. Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase. EMBO J. 15:817-826.
33. Selander K, Lehenkari P, Vaananen HK. 1994. The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif. Tissue Int. 55:368-375.
34. Takami M, Kim N, Rho J, Choi Y. 2002. Stimulation by toll-like receptors inhibits osteoclast differentiation. J. Immunol. 169:1516-1523.
35. Takayanagi H, et al. 2002. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3:889-901.
36. Takebe Y, et al. 1988. SRα promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:466-472.
37. Tanaka S, Nakamura K, Takahasi N, Suda T. 2005. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol. Rev. 208:30-49.
38. Taubman MA, Kawai T. 2001. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit. Rev. Oral Biol. Med. 12:125-135.
39. Tsatsanis C, Patriotis C, Bear SE, Tsichlis PN. 1998. The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines. Proc. Natl. Acad. Sci. U. S. A. 95:3827-3832.
40. Tsatsanis C, Patriotis C, Tsichlis PN. 1998. Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB. Oncogene 17:2609-2618.
41. Yagi M, et al. 2005. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202:345-351.
42. Yeo H, et al. 2007. Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption. J. Biol. Chem. 282:35318-35327.