Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts

Journal of Dental Research

Volumn 82, Issue 7, 2003, Pages 546-550

  Kikuchi, T ^a,b   Yoshikai, Y ^c   Miyoshi, J ^d   Katsuki, M ^e   Musikacharoen, T ^a   Mitani, A ^b   Tanaka, S ^b   Noguchi, T ^b   Matsuguchi, T ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^e NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

Author keywords

Cot; Lipid A; Osteoblast; RANKL; Tpl2

Indexed keywords

CELL RECEPTOR; GLYCOPROTEIN; LIPID A; MAP3K8 PROTEIN, MOUSE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; ONCOPROTEIN; OSTEOPROTEGERIN; TNFRSF11B PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MOUSE; NORTHERN BLOTTING; OSTEOBLAST; OSTEOCLAST; UPREGULATION;

ANIMALS; BLOTTING, NORTHERN; CELL DIFFERENTIATION; CELLS, CULTURED; ENZYME ACTIVATION; GLYCOPROTEINS; LIPID A; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOBLASTS; OSTEOCLASTS; OSTEOPROTEGERIN; PROTO-ONCOGENE PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; UP-REGULATION;

EID: 0037779034     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910308200712     Document Type: Article

References (28)

1. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, et al. (1997). A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175-179.
2. Belich MP, Salmeron A, Johnston LH, Ley SC (1999). TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Nature 397:363-368.
3. Carson RE, Sayegh FS, Fedi PF Jr (1978). Osteoclastic resorption of alveolar bone affected by periodontitis - correlation of light microscopic and scanning electron microscopic observations. J Periodontol 49:406-414.
4. Chiariello M, Marinissen MJ, Gutkind JS (2000). Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol 20:1747-1758.
5. Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, et al. (2000). TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103:1071-1083.
6. Fuller K, Wong B, Fox S, Choi Y, Chambers TJ (1998). TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med 188:997-1001.
7. Guthridge CJ, Eidlen D, Arend WP, Gutierrez-Hartmann A, Smith MF Jr (1997). Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms. Mol Cell Biol 17:1118-1128.
8. Higashi T, Sasai H, Suzuki F, Miyoshi J, Ohuchi T, Takai S, et al. (1990). Hamster cell line suitable for transfection assay of transforming genes. Proc Natl Acad Sci USA 87:2409-2413.
9. Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, et al. (2001). Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 166:3574-3579.
10. Kitazawa R, Kitazawa S, Maeda S (1999). Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta 1445:134-141.
11. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, et al. (1999). OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323.
12. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, et al. (1998). Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176.
13. Malyankar UM, Scatena M, Suchland KL, Yun TJ, Clark EA, Giachelli CM (2000). Osteoprotegerin is an alpha vbeta 3-induced, NF-kappa B-dependent survival factor for endothelial cells. J Biol Chem 275:20959-20962.
14. Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T (1991). Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. Mol Cell Biol 11:4088-4096.
15. Monick MM, Carter AB, Flaherty DM, Peterson MW, Hunninghake GW (2000). Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. J Immunol 165:4632-4639.
16. Patriotis C, Makris A, Bear SE, Tsichlis PN (1993). Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci USA 90:2251-2255.
17. Patriotis C, Makris A, Chernoff J, Tsichlis PN (1994). Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc Natl Acad Sci USA 91:9755-9759.
18. Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP, Ley SC (1996). Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J 15:817-826.
19. Schletter J, Heine H, Ulmer AJ, Rietschel ET (1995). Molecular mechanisms of endotoxin activity. Arch Microbiol 164:383-389.
20. Suda K, Woo JT, Takami M, Sexton PM, Nagai K (2002). Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL. J Cell Physiol 190:101-108.
21. Sweet MJ, Hume DA (1996). Endotoxin signal transduction in macrophages. J Leukoc Biol 60:8-26.
22. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, et al. (1988). Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600-2602.
23. Widmann C, Gibson S, Jarpe MB, Johnson GL (1999). Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180.
24. Wong BR, Josien R, Lee SY, Sauter B, Li HL, Steinman RM, et al. (1997a). TRANCE (tumor necrosis factor [TNF] -related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 186:2075-2080.
25. Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, et al. (1997b). TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 272:25190-25194.
26. Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, et al. (1999). TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell 4:1041-1049.
27. Xiao Q, Jiang D, Thomas P, Benson MD, Guan K, Karsenty GS, et al. (2000). MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 275:4453-4459.
28. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, et al. (1998). Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95:3597-3602.