NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the lipin1 and PGC-1β Genes

Molecular and Cellular Biology

Volumn 32, Issue 14, 2012, Pages 2760-2770

  Hirotsu, Yosuke ^a   Hataya, Nami ^a   Katsuok, Fumiki ^a   Yamamoto, Masayuki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; LIPID; LIPIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; TRANSCRIPTION FACTOR NRF1; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; BINDING KINETICS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; INTRON; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; LIVER METABOLISM; MICROARRAY ANALYSIS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REPORTER GENE; RNA PURIFICATION; SEQUENCE ANALYSIS;

MUS;

EID: 84864003934     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06706-11     Document Type: Article

References (56)

1. Aoyama T, et al. 1998. Altered constitutive expression of fatty acidmetabolizing enzymes in mice lacking the peroxisome proliferatoractivated receptor alpha (PPARalpha). J. Biol. Chem. 273:5678 -5684.
2. Chan J, et al. 1998. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 17:1779 -1787.
3. Chowdhry S, et al. 2010. Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free Radic. Biol. Med. 48:357-371.
4. Cohen JC, Horton JD, Hobbs HH. 2011. Human fatty liver disease: old questions and new insights. Science 332:1519 -1523.
5. Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. 2004. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol. Cell. Biol. 24:8477-8486.
6. Finck BN, et al. 2006. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 4:199 -210.
7. Friling R, Bensimon A, Tichauer Y, Daniel V. 1990. Xenobioticinducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element. Proc. Natl. Acad. Sci. U. S. A. 87:6258-6262.
8. Gordan JD, Thompson CB, Simon MC. 2007. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12:108 -113.
9. Hotamisligil GS. 2010. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900 -917.
10. Huang J, Tabbi-Anneni I, Gunda V, Wang L. 2010. Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism. Am. J. Physiol. Gastrointest. Liver Physiol. 299:G1211-G1221.
11. Igarashi K, et al. 1994. Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Nature 367:568 -572.
12. Itoh K, et al. 1997. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236:313-322.
13. Itoh K, et al. 1999. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13:76-86.
14. Joshi-Tope G, et al. 2005. Reactome: a knowledgebase of biological pathways. Nucleic Acids Res. 33:D428-D432.
15. Kataoka K, Noda M, Nishizawa M. 1994. Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. Mol. Cell. Biol. 14:700 -712.
16. Katsuoka F, et al. 2005. Genetic evidence that small Maf proteins are essential for the activation of antioxidant response element-dependent genes. Mol. Cell. Biol. 25:8044-8051.
17. Kelly DP, Scarpulla RC. 2004. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18:357-368.
18. Kersten S, et al. 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103:1489 -1498.
19. Kobayashi A, et al. 2004. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2. Mol. Cell. Biol. 24:7130 -7139.
20. Kobayashi A, et al. 2011. Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells 16:692-703.
21. Kurokawa H, et al. 2009. Structural basis of alternative DNA recognition by Maf transcription factors. Mol. Cell. Biol. 29:6232-6244.
22. Kyo M, et al. 2004. Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging technique. Genes Cells 9:153-164.
23. Lee CS, et al. 2011. Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc. Natl. Acad. Sci. U. S. A. 108:8408-8413.
24. Lelliott CJ, et al. 2006. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 4:e369. doi:10.1371/journal.pbio.0040369.
25. Leone TC, Weinheimer CJ, Kelly DP. 1999. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U. S. A. 96:7473-7478.
26. Leung L, Kwong M, Hou S, Lee C, Chan JY. 2003. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J. Biol. Chem. 278:48021-48029.
27. -/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology 46:1413-1425.
28. Lu SC, et al. 2001. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc. Natl. Acad. Sci. U. S. A. 98:5560 -5565.
29. Mato JM, Martínez-Chantar ML, Lu SC. 2008. Methionine metabolism and liver disease. Annu. Rev. Nutr. 28:273-293.
30. Motohashi H, et al. 2006. MafG sumoylation is required for active transcriptional repression. Mol. Cell. Biol. 26:4652-4663.
31. Motohashi H, O'Connor T, Katsuoka F, Engel J, Yamamoto M. 2002.Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene 294:1-12.
32. Motohashi H, Shavit JA, Igarashi K, Yamamoto M, Engel JD. 1997. The world according to Maf. Nucleic Acids Res. 25:2953-2959.
33. Ohtsuji M, et al. 2008. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J. Biol. Chem. 283: 33554-33562.
34. Péterfy M, Phan J, Xu P, Reue K. 2001. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27:121-124.
35. Pi J, et al. 2010. Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J. Biol. Chem. 285:9292-9300.
36. Radhakrishnan SK, et al. 2010. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol. Cell 38:17-28.
37. Rakhshandehroo M, Knoch B, Müller M, Kersten S. 2010. Peroxisome proliferator-activated receptor alpha target genes. PPAR Res. 2010: pii 612089. doi:10.1155/2010/612089.
38. Rehnmark S, Giometti CS, Slavin BG, Doolittle MH, Reue K. 1998. The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins. J. Lipid Res. 39:2209 -2217.
39. Rushmore T, Morton M, Pickett C. 1991. The antioxidant responsive element. Activation by oxidative stress and identification of theDNAconsensus sequence required for functional activity. J. Biol. Chem. 266: 11632-11639.
40. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M. 2000. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852.
41. Shimano H, et al. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98:1575-1584.
42. Shin S, et al. 2009. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur. J. Pharmacol. 620:138 -144.
43. Soga T, et al. 2006. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J. Biol. Chem. 281:16768 -16776.
44. Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM. 2007. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc. Natl. Acad. Sci. U. S. A. 104:5223-5228.
45. Steffen J, Seeger M, Koch A, Krüger E. 2010. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Mol. Cell 40:147-158.
46. Sugimoto H, et al. 2010. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 298:G283-G294.
47. Sykiotis GP, Bohmann D. 2010. Stress-activated cap'n'collar transcription factors in aging and human disease. Sci. Signal. 3:re3. doi:10.1126/ scisignal.3112re3.
48. Taguchi K, et al. 2010. Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol. Cell. Biol. 30:3016 -3026.
49. Tanaka Y, et al. 2008. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J. Pharmacol. Exp. Ther. 325:655-664.
50. Vianna CR, et al. 2006. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 4:453-464.
51. Wang W, Chan JY. 2006. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J. Biol. Chem. 281:19676-19687.
52. Xu ZR, et al. 2005. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc. Natl. Acad. Sci. U. S. A. 102:4120-4125.
53. Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. 2004. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24:10941-10953.
54. Zhang J, et al. 2006. BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol. Cell. Biol. 26:7942-7952.
55. Zhang Y, Crouch DH, Yamamoto M, Hayes JD. 2006. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem. J. 399:373-385.
56. Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. 2010. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionineand choline-deficient diet. Toxicol. Appl. Pharmacol. 245:326 -334.