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Volumn 14, Issue 8, 2012, Pages 1242-1256

A role of autophagy in Trypanosoma brucei cell death

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; WORTMANNIN;

EID: 84863991249     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2012.01795.x     Document Type: Article
Times cited : (47)

References (67)
  • 1
    • 0029764290 scopus 로고    scopus 로고
    • A soluble secretory reporter system in Trypanosoma brucei. Studies on endoplasmic reticulum targeting
    • Bangs, J.D., Brouch, E.M., Ransom, D.M., and Roggy, J.L. (1996) A soluble secretory reporter system in Trypanosoma brucei. Studies on endoplasmic reticulum targeting. J Biol Chem 271: 18387-18393.
    • (1996) J Biol Chem , vol.271 , pp. 18387-18393
    • Bangs, J.D.1    Brouch, E.M.2    Ransom, D.M.3    Roggy, J.L.4
  • 2
    • 61649084207 scopus 로고    scopus 로고
    • Trypanosome TOR as a major regulator of cell growth and autophagy
    • Barquilla, A., and Navarro, M. (2009) Trypanosome TOR as a major regulator of cell growth and autophagy. Autophagy 5: 256-258.
    • (2009) Autophagy , vol.5 , pp. 256-258
    • Barquilla, A.1    Navarro, M.2
  • 3
    • 55749100531 scopus 로고    scopus 로고
    • Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation
    • Barquilla, A., Crespo, J.L., and Navarro, M. (2008) Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation. Proc Natl Acad Sci USA 105: 14579-14584.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14579-14584
    • Barquilla, A.1    Crespo, J.L.2    Navarro, M.3
  • 4
    • 0029894292 scopus 로고    scopus 로고
    • A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei
    • Bastin, P., Bagherzadeh, Z., Matthews, K.R., and Gull, K. (1996) A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei. Mol Biochem Parasitol 77: 235-239.
    • (1996) Mol Biochem Parasitol , vol.77 , pp. 235-239
    • Bastin, P.1    Bagherzadeh, Z.2    Matthews, K.R.3    Gull, K.4
  • 5
    • 0037373689 scopus 로고    scopus 로고
    • Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides
    • Bera, A. (2003) Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides. Mol Biochem Parasitol 127: 23-35.
    • (2003) Mol Biochem Parasitol , vol.127 , pp. 23-35
    • Bera, A.1
  • 6
    • 84855286487 scopus 로고    scopus 로고
    • Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites
    • Besteiro, S., Brooks, C.F., Striepen, B., and Dubremetz, J.F. (2011) Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites. PLoS Pathog 7: e1002416.
    • (2011) PLoS Pathog , vol.7
    • Besteiro, S.1    Brooks, C.F.2    Striepen, B.3    Dubremetz, J.F.4
  • 7
    • 0030957959 scopus 로고    scopus 로고
    • Autophagic proteolysis: control and specificity
    • Blommaart, E.F., Luiken, J.J., and Meijer, A.J. (1997) Autophagic proteolysis: control and specificity. Histochem J 29: 365-385.
    • (1997) Histochem J , vol.29 , pp. 365-385
    • Blommaart, E.F.1    Luiken, J.J.2    Meijer, A.J.3
  • 9
    • 73449135758 scopus 로고    scopus 로고
    • Human African trypanosomiasis
    • Brun, R., Blum, J., Chappuis, F., and Burri, C. (2010) Human African trypanosomiasis. Lancet 375: 148-159.
    • (2010) Lancet , vol.375 , pp. 148-159
    • Brun, R.1    Blum, J.2    Chappuis, F.3    Burri, C.4
  • 10
    • 60849108318 scopus 로고    scopus 로고
    • Neuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death
    • Delgado, M., Anderson, P., Garcia-Salcedo, J.A., Caro, M., and Gonzalez-Rey, E. (2009) Neuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death. Cell Death Differ 16: 406-416.
    • (2009) Cell Death Differ , vol.16 , pp. 406-416
    • Delgado, M.1    Anderson, P.2    Garcia-Salcedo, J.A.3    Caro, M.4    Gonzalez-Rey, E.5
  • 12
    • 75149170191 scopus 로고    scopus 로고
    • Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy
    • Denton, D., Shravage, B., Simin, R., Baehrecke, E.H., and Kumar, S. (2010) Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy. Autophagy 6: 163-165.
    • (2010) Autophagy , vol.6 , pp. 163-165
    • Denton, D.1    Shravage, B.2    Simin, R.3    Baehrecke, E.H.4    Kumar, S.5
  • 13
    • 0033216636 scopus 로고    scopus 로고
    • 2+ storage compartment in trypanosomatids and apicomplexan parasites
    • 2+ storage compartment in trypanosomatids and apicomplexan parasites. Parasitol Today 15: 443-448.
    • (1999) Parasitol Today , vol.15 , pp. 443-448
    • Docampo, R.1    Moreno, S.N.2
  • 17
    • 0031985647 scopus 로고    scopus 로고
    • Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure
    • van Engeland, M., Nieland, L.J., Ramaekers, F.C., Schutte, B., and Reutelingsperger, C.P. (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9.
    • (1998) Cytometry , vol.31 , pp. 1-9
    • van Engeland, M.1    Nieland, L.J.2    Ramaekers, F.C.3    Schutte, B.4    Reutelingsperger, C.P.5
  • 18
    • 33846010776 scopus 로고    scopus 로고
    • Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes
    • Fass, E., Shvets, E., Degani, I., Hirschberg, K., and Elazar, Z. (2006) Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem 281: 36303-36316.
    • (2006) J Biol Chem , vol.281 , pp. 36303-36316
    • Fass, E.1    Shvets, E.2    Degani, I.3    Hirschberg, K.4    Elazar, Z.5
  • 19
    • 17144420138 scopus 로고    scopus 로고
    • Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form
    • Figarella, K., Rawer, M., Uzcategui, N.L., Kubata, B.K., Lauber, K., Madeo, F., etal. (2005) Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. Cell Death Differ 12: 335-346.
    • (2005) Cell Death Differ , vol.12 , pp. 335-346
    • Figarella, K.1    Rawer, M.2    Uzcategui, N.L.3    Kubata, B.K.4    Lauber, K.5    Madeo, F.6
  • 20
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • Fung, C., Lock, R., Gao, S., Salas, E., and Debnath, J. (2008) Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 19: 797-806.
    • (2008) Mol Biol Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 21
    • 84858290288 scopus 로고    scopus 로고
    • Autophagy is a cell death mechanism in Toxoplasma gondii
    • Ghosh, D., Walton, J.L., Roepe, P.D., and Sinai, A.P. (2012) Autophagy is a cell death mechanism in Toxoplasma gondii. Cell Microbiol 14: 589-607.
    • (2012) Cell Microbiol , vol.14 , pp. 589-607
    • Ghosh, D.1    Walton, J.L.2    Roepe, P.D.3    Sinai, A.P.4
  • 22
    • 77649219141 scopus 로고    scopus 로고
    • Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei
    • Goldshmidt, H., Matas, D., Kabi, A., Carmi, S., Hope, R., and Michaeli, S. (2010) Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei. PLoS Pathog 6: e1000731.
    • (2010) PLoS Pathog , vol.6
    • Goldshmidt, H.1    Matas, D.2    Kabi, A.3    Carmi, S.4    Hope, R.5    Michaeli, S.6
  • 23
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He, C., and Klionsky, D.J. (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 24
    • 27944451395 scopus 로고    scopus 로고
    • Golgi duplication in Trypanosoma brucei requires Centrin2
    • He, C.Y., Pypaert, M., and Warren, G. (2005) Golgi duplication in Trypanosoma brucei requires Centrin2. Science 310: 1196-1198.
    • (2005) Science , vol.310 , pp. 1196-1198
    • He, C.Y.1    Pypaert, M.2    Warren, G.3
  • 25
    • 33645943693 scopus 로고    scopus 로고
    • Autophagy and related processes in trypanosomatids: insights from genomic and bioinformatic analyses
    • Herman, M., Gillies, S., Michels, P.A., and Rigden, D.J. (2006) Autophagy and related processes in trypanosomatids: insights from genomic and bioinformatic analyses. Autophagy 2: 107-118.
    • (2006) Autophagy , vol.2 , pp. 107-118
    • Herman, M.1    Gillies, S.2    Michels, P.A.3    Rigden, D.J.4
  • 26
    • 41449083862 scopus 로고    scopus 로고
    • Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei
    • Herman, M., Perez-Morga, D., Schtickzelle, N., and Michels, P.A. (2008) Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei. Autophagy 4: 294-308.
    • (2008) Autophagy , vol.4 , pp. 294-308
    • Herman, M.1    Perez-Morga, D.2    Schtickzelle, N.3    Michels, P.A.4
  • 27
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., etal. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6
  • 28
    • 3242888703 scopus 로고    scopus 로고
    • LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
    • Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., and Yoshimori, T. (2004) LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117: 2805-2812.
    • (2004) J Cell Sci , vol.117 , pp. 2805-2812
    • Kabeya, Y.1    Mizushima, N.2    Yamamoto, A.3    Oshitani-Okamoto, S.4    Ohsumi, Y.5    Yoshimori, T.6
  • 29
    • 0023855137 scopus 로고
    • Cultivation of the life cycle stages of Trypanosoma brucei sspp
    • Kaminsky, R., Beaudoin, E., and Cunningham, I. (1988) Cultivation of the life cycle stages of Trypanosoma brucei sspp. Acta Trop 45: 33-43.
    • (1988) Acta Trop , vol.45 , pp. 33-43
    • Kaminsky, R.1    Beaudoin, E.2    Cunningham, I.3
  • 30
    • 77349113185 scopus 로고    scopus 로고
    • Autophagy in unicellular eukaryotes
    • Kiel, J.A. (2010) Autophagy in unicellular eukaryotes. Philos Trans R Soc Lond B Biol Sci 365: 819-830.
    • (2010) Philos Trans R Soc Lond B Biol Sci , vol.365 , pp. 819-830
    • Kiel, J.A.1
  • 32
    • 0034676037 scopus 로고    scopus 로고
    • The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
    • Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., etal. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 151: 263-276.
    • (2000) J Cell Biol , vol.151 , pp. 263-276
    • Kirisako, T.1    Ichimura, Y.2    Okada, H.3    Kabeya, Y.4    Mizushima, N.5    Yoshimori, T.6
  • 33
    • 50249183899 scopus 로고    scopus 로고
    • Autophagy revisited: a conversation with Christian de Duve
    • Klionsky, D.J. (2008) Autophagy revisited: a conversation with Christian de Duve. Autophagy 4: 740-743.
    • (2008) Autophagy , vol.4 , pp. 740-743
    • Klionsky, D.J.1
  • 34
    • 73449097796 scopus 로고    scopus 로고
    • Trypanosoma brucei ATG8: structural insights into autophagic-like mechanisms in protozoa
    • Koopmann, R., Muhammad, K., Perbandt, M., Betzel, C., and Duszenko, M. (2009) Trypanosoma brucei ATG8: structural insights into autophagic-like mechanisms in protozoa. Autophagy 5: 1085-1091.
    • (2009) Autophagy , vol.5 , pp. 1085-1091
    • Koopmann, R.1    Muhammad, K.2    Perbandt, M.3    Betzel, C.4    Duszenko, M.5
  • 35
    • 0037020160 scopus 로고    scopus 로고
    • +-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei
    • +-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei. J Biol Chem 277: 37369-37376.
    • (2002) J Biol Chem , vol.277 , pp. 37369-37376
    • Lemercier, G.1    Dutoya, S.2    Luo, S.3    Ruiz, F.A.4    Rodrigues, C.O.5    Baltz, T.6
  • 36
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: crosstalk between autophagy and apoptosis
    • Maiuri, M.C., Zalckvar, E., Kimchi, A., and Kroemer, G. (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 37
    • 0030792850 scopus 로고    scopus 로고
    • Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line
    • Mancini, M., Anderson, B.O., Caldwell, E., Sedghinasab, M., Paty, P.B., and Hockenbery, D.M. (1997) Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line. J Cell Biol 138: 449-469.
    • (1997) J Cell Biol , vol.138 , pp. 449-469
    • Mancini, M.1    Anderson, B.O.2    Caldwell, E.3    Sedghinasab, M.4    Paty, P.B.5    Hockenbery, D.M.6
  • 39
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima, N., Yoshimori, T., and Levine, B. (2010) Methods in mammalian autophagy research. Cell 140: 313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 40
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy
    • Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X.H., Mizushima, N., etal. (2005) Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy. Cell 122: 927-939.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 41
    • 42549120380 scopus 로고    scopus 로고
    • The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes
    • Peck, R.F., Shiflett, A.M., Schwartz, K.J., McCann, A., Hajduk, S.L., and Bangs, J.D. (2008) The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes. Mol Microbiol 68: 933-946.
    • (2008) Mol Microbiol , vol.68 , pp. 933-946
    • Peck, R.F.1    Shiflett, A.M.2    Schwartz, K.J.3    McCann, A.4    Hajduk, S.L.5    Bangs, J.D.6
  • 42
    • 76249124608 scopus 로고    scopus 로고
    • Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
    • Puissant, A., Robert, G., Fenouille, N., Luciano, F., Cassuto, J.P., Raynaud, S., and Auberger, P. (2010) Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res 70: 1042-1052.
    • (2010) Cancer Res , vol.70 , pp. 1042-1052
    • Puissant, A.1    Robert, G.2    Fenouille, N.3    Luciano, F.4    Cassuto, J.P.5    Raynaud, S.6    Auberger, P.7
  • 43
    • 77955637249 scopus 로고    scopus 로고
    • ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death
    • Radoshevich, L., Murrow, L., Chen, N., Fernandez, E., Roy, S., Fung, C., and Debnath, J. (2010) ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 142: 590-600.
    • (2010) Cell , vol.142 , pp. 590-600
    • Radoshevich, L.1    Murrow, L.2    Chen, N.3    Fernandez, E.4    Roy, S.5    Fung, C.6    Debnath, J.7
  • 44
    • 48749131672 scopus 로고    scopus 로고
    • Interactions between trypanosomes and tsetse flies
    • Roditi, I., and Lehane, M.J. (2008) Interactions between trypanosomes and tsetse flies. Curr Opin Microbiol 11: 345-351.
    • (2008) Curr Opin Microbiol , vol.11 , pp. 345-351
    • Roditi, I.1    Lehane, M.J.2
  • 45
    • 0020959336 scopus 로고
    • African trypanosomes contain calmodulin which is distinct from host calmodulin
    • Rubben, L., Egwuagu, C., and Patton, C. (1983) African trypanosomes contain calmodulin which is distinct from host calmodulin. Biochim Biophys Acta 758: 104-113.
    • (1983) Biochim Biophys Acta , vol.758 , pp. 104-113
    • Rubben, L.1    Egwuagu, C.2    Patton, C.3
  • 46
    • 84856431622 scopus 로고    scopus 로고
    • The end of autophagic cell death?
    • Shen, S., Kepp, O., and Kroemer, G. (2012) The end of autophagic cell death? Autophagy 8: 1-3.
    • (2012) Autophagy , vol.8 , pp. 1-3
    • Shen, S.1    Kepp, O.2    Kroemer, G.3
  • 47
    • 0033928734 scopus 로고    scopus 로고
    • Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA
    • Shi, H., Djikeng, A., Mark, T., Wirtz, E., Tschudi, C., and Ullu, E. (2000) Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA. RNA 6: 1069-1076.
    • (2000) RNA , vol.6 , pp. 1069-1076
    • Shi, H.1    Djikeng, A.2    Mark, T.3    Wirtz, E.4    Tschudi, C.5    Ullu, E.6
  • 49
    • 33645652024 scopus 로고    scopus 로고
    • Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16
    • Sou, Y.S., Tanida, I., Komatsu, M., Ueno, T., and Kominami, E. (2006) Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem 281: 3017-3024.
    • (2006) J Biol Chem , vol.281 , pp. 3017-3024
    • Sou, Y.S.1    Tanida, I.2    Komatsu, M.3    Ueno, T.4    Kominami, E.5
  • 50
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen, C.C., Kang, S.A., Chang, J.W., Liu, Q., Zhang, J., Gao, Y., etal. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023-8032.
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3    Liu, Q.4    Zhang, J.5    Gao, Y.6
  • 51
    • 45849147350 scopus 로고    scopus 로고
    • A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
    • Turcotte, S., Chan, D.A., Sutphin, P.D., Hay, M.P., Denny, W.A., and Giaccia, A.J. (2008) A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 14: 90-102.
    • (2008) Cancer Cell , vol.14 , pp. 90-102
    • Turcotte, S.1    Chan, D.A.2    Sutphin, P.D.3    Hay, M.P.4    Denny, W.A.5    Giaccia, A.J.6
  • 52
    • 35848952558 scopus 로고    scopus 로고
    • Antiproliferative effect of dihydroxyacetone on Trypanosoma brucei bloodstream forms: cell cycle progression, subcellular alterations, and cell death
    • Uzcategui, N.L., Carmona-Gutierrez, D., Denninger, V., Schoenfeld, C., Lang, F., Figarella, K., and Duszenko, M. (2007a) Antiproliferative effect of dihydroxyacetone on Trypanosoma brucei bloodstream forms: cell cycle progression, subcellular alterations, and cell death. Antimicrob Agents Chemother 51: 3960-3968.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3960-3968
    • Uzcategui, N.L.1    Carmona-Gutierrez, D.2    Denninger, V.3    Schoenfeld, C.4    Lang, F.5    Figarella, K.6    Duszenko, M.7
  • 54
    • 77953286807 scopus 로고    scopus 로고
    • Mitochondrial membrane potential-based genome-wide RNAi screen of Trypanosoma brucei
    • Verner, Z., Paris, Z., and Lukes, J. (2010) Mitochondrial membrane potential-based genome-wide RNAi screen of Trypanosoma brucei. Parasitol Res 106: 1241-1244.
    • (2010) Parasitol Res , vol.106 , pp. 1241-1244
    • Verner, Z.1    Paris, Z.2    Lukes, J.3
  • 56
    • 0034704084 scopus 로고    scopus 로고
    • Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters
    • Wang, Z., Morris, J.C., Drew, M.E., and Englund, P.T. (2000) Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J Biol Chem 275: 40174-40179.
    • (2000) J Biol Chem , vol.275 , pp. 40174-40179
    • Wang, Z.1    Morris, J.C.2    Drew, M.E.3    Englund, P.T.4
  • 57
    • 77953122645 scopus 로고    scopus 로고
    • LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
    • Weidberg, H., Shvets, E., Shpilka, T., Shimron, F., Shinder, V., and Elazar, Z. (2010) LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J 29: 1792-1802.
    • (2010) EMBO J , vol.29 , pp. 1792-1802
    • Weidberg, H.1    Shvets, E.2    Shpilka, T.3    Shimron, F.4    Shinder, V.5    Elazar, Z.6
  • 58
    • 79954544250 scopus 로고    scopus 로고
    • LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis
    • Weidberg, H., Shpilka, T., Shvets, E., Abada, A., Shimron, F., and Elazar, Z. (2011) LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis. Dev Cell 20: 444-454.
    • (2011) Dev Cell , vol.20 , pp. 444-454
    • Weidberg, H.1    Shpilka, T.2    Shvets, E.3    Abada, A.4    Shimron, F.5    Elazar, Z.6
  • 60
    • 33748300634 scopus 로고    scopus 로고
    • Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana
    • Williams, R.A., Tetley, L., Mottram, J.C., and Coombs, G.H. (2006) Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana. Mol Microbiol 61: 655-674.
    • (2006) Mol Microbiol , vol.61 , pp. 655-674
    • Williams, R.A.1    Tetley, L.2    Mottram, J.C.3    Coombs, G.H.4
  • 61
    • 61649127283 scopus 로고    scopus 로고
    • Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major
    • Williams, R.A., Woods, K.L., Juliano, L., Mottram, J.C., and Coombs, G.H. (2009) Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy 5: 159-172.
    • (2009) Autophagy , vol.5 , pp. 159-172
    • Williams, R.A.1    Woods, K.L.2    Juliano, L.3    Mottram, J.C.4    Coombs, G.H.5
  • 62
    • 0033525524 scopus 로고    scopus 로고
    • A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei
    • Wirtz, E., Leal, S., Ochatt, C., and Cross, G.A. (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol 99: 89-101.
    • (1999) Mol Biochem Parasitol , vol.99 , pp. 89-101
    • Wirtz, E.1    Leal, S.2    Ochatt, C.3    Cross, G.A.4
  • 63
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: a history of macroautophagy
    • Yang, Z., and Klionsky, D.J. (2010) Eaten alive: a history of macroautophagy. Nat Cell Biol 12: 814-822.
    • (2010) Nat Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 64
    • 14744268915 scopus 로고    scopus 로고
    • Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy
    • Yoshimoto, K., Hanaoka, H., Sato, S., Kato, T., Tabata, S., Noda, T., and Ohsumi, Y. (2004) Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell 16: 2967-2983.
    • (2004) Plant Cell , vol.16 , pp. 2967-2983
    • Yoshimoto, K.1    Hanaoka, H.2    Sato, S.3    Kato, T.4    Tabata, S.5    Noda, T.6    Ohsumi, Y.7
  • 65
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., etal. (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6
  • 66
    • 77956882084 scopus 로고    scopus 로고
    • Programmed cell death in unicellular parasites: a prerequisite for sustained infection?
    • van Zandbergen, G., Luder, C.G., Heussler, V., and Duszenko, M. (2010) Programmed cell death in unicellular parasites: a prerequisite for sustained infection? Trends Parasitol 26: 477-483.
    • (2010) Trends Parasitol , vol.26 , pp. 477-483
    • van Zandbergen, G.1    Luder, C.G.2    Heussler, V.3    Duszenko, M.4
  • 67
    • 0029071264 scopus 로고
    • TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
    • Zheng, X.F., Florentino, D., Chen, J., Crabtree, G.R., and Schreiber, S.L. (1995) TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82: 121-130.
    • (1995) Cell , vol.82 , pp. 121-130
    • Zheng, X.F.1    Florentino, D.2    Chen, J.3    Crabtree, G.R.4    Schreiber, S.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.