Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei

PLoS Pathogens

Volumn 6, Issue 1, 2010, Pages

  Goldshmidt, Hanoch ^a   Matas, Devorah ^a   Kabi, Anat ^a   Carmi, Shai ^a   Hope, Ronen ^a   Michaeli, Shulamit ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTOME; MESSENGER RNA; SPLICED LEADER RNA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RNA SPLICING; RNA TRANSCRIPTION; TRANSMISSION ELECTRON MICROSCOPY; TRYPANOSOMA BRUCEI; DNA MICROARRAY; ENDOPLASMIC RETICULUM; EUKARYOTE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOELECTRON MICROSCOPY; METABOLISM; NICK END LABELING; NORTHERN BLOTTING; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

EUKARYOTA; HEXAPODA; MAMMALIA; TRYPANOSOMA BRUCEI;

APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; EUKARYOTA; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENE SILENCING; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, IMMUNOELECTRON; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SPLICED LEADER; STRESS, PHYSIOLOGICAL; TRYPANOSOMA BRUCEI BRUCEI; UNFOLDED PROTEIN RESPONSE;

EID: 77649219141     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000731     Document Type: Article

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