메뉴 건너뛰기




Volumn 43, Issue 8, 2012, Pages 1197-1205

PIK3CA mutations in endometrial carcinomas in Chinese women: Phosphatidylinositol 3′-kinase pathway alterations might be associated with favorable prognosis

Author keywords

Chinese women; Endometrial carcinomas; PI3K AKT pathway alteration; PIK3CA mutations; Prognosis

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN; PROGESTERONE RECEPTOR; PROTEIN KINASE B; PROTEIN P53; SERINE; TENSIN; THREONINE; UNCLASSIFIED DRUG;

EID: 84863987220     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.08.021     Document Type: Article
Times cited : (12)

References (26)
  • 1
    • 0029799612 scopus 로고    scopus 로고
    • Endometrial carcinoma
    • DOI 10.1056/NEJM199608293350907
    • P.G. Rose Endometrial carcinoma N Engl J Med 335 1996 640 649 (Pubitemid 26277956)
    • (1996) New England Journal of Medicine , vol.335 , Issue.9 , pp. 640-649
    • Rose, P.G.1
  • 2
    • 63849308483 scopus 로고    scopus 로고
    • Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
    • H.B. Salvesen, S.L. Carter, and M. Mannelqvist Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation Proc Natl Acad Sci U S A 106 2009 4834 4839
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4834-4839
    • Salvesen, H.B.1    Carter, S.L.2    Mannelqvist, M.3
  • 3
    • 70349140898 scopus 로고    scopus 로고
    • Molecular pathology of endometrial carcinoma: Practical aspects from the diagnostic and therapeutic viewpoints
    • D. Llobet, J. Pallares, and A. Yeramian Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints J Clin Pathol 62 2009 777 785
    • (2009) J Clin Pathol , vol.62 , pp. 777-785
    • Llobet, D.1    Pallares, J.2    Yeramian, A.3
  • 4
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501 (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 7
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • DOI 10.1097/01.cco.0000198021.99347.b9, PII 0000162220060100000013
    • Y. Samuels, and K. Ericson Oncogenic PI3K and its role in cancer Curr Opin Oncol 18 2006 77 82 (Pubitemid 43740454)
    • (2006) Current Opinion in Oncology , vol.18 , Issue.1 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 8
    • 0038274803 scopus 로고    scopus 로고
    • Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer
    • DOI 10.1677/erc.0.0100203
    • N. Terakawa, Y. Kanamori, and S. Yoshida Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer Endocr Relat Cancer 10 2003 203 208 (Pubitemid 36758649)
    • (2003) Endocrine-Related Cancer , vol.10 , Issue.2 , pp. 203-208
    • Terakawa, N.1    Kanamori, Y.2    Yoshida, S.3
  • 9
    • 24744448247 scopus 로고    scopus 로고
    • PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma
    • K. Uegaki, Y. Kanamori, and J. Kigawa PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma Oncol Rep 14 2005 389 392
    • (2005) Oncol Rep , vol.14 , pp. 389-392
    • Uegaki, K.1    Kanamori, Y.2    Kigawa, J.3
  • 10
    • 38649090091 scopus 로고    scopus 로고
    • PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    • DOI 10.1038/modpathol.3800992, PII 3800992
    • L. Catasus, A. Gallardo, M. Cuatrecasas, and J. Prat PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters Mod Pathol 21 2008 131 139 (Pubitemid 351172164)
    • (2008) Modern Pathology , vol.21 , Issue.2 , pp. 131-139
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 11
    • 63949083916 scopus 로고    scopus 로고
    • Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis
    • L. Catasus, A. Gallardo, M. Cuatrecasas, and J. Prat Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis Mod Pathol 22 2009 522 529
    • (2009) Mod Pathol , vol.22 , pp. 522-529
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 12
    • 77952009540 scopus 로고    scopus 로고
    • Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations
    • L. Catasus, E. D'Angeld, and C. Pons Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations Mod Pathol 23 2010 694 702
    • (2010) Mod Pathol , vol.23 , pp. 694-702
    • Catasus, L.1    D'Angeld, E.2    Pons, C.3
  • 13
    • 84879192085 scopus 로고    scopus 로고
    • Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer
    • D. Konstantinova, R. Kaneva, and R. Dimitrov Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer DNA Cell Biol 29 2010 65 70
    • (2010) DNA Cell Biol , vol.29 , pp. 65-70
    • Konstantinova, D.1    Kaneva, R.2    Dimitrov, R.3
  • 14
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
    • F.J. Esteva, H. Guo, and S. Zhang PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer Am J Pathol 177 2010 1647 1656
    • (2010) Am J Pathol , vol.177 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3
  • 15
    • 33744914835 scopus 로고    scopus 로고
    • Lack of correlation between leptin receptor expression and PI3-K/Akt signaling pathway proteins immunostaining in endometrioid-type endometrial carcinomas
    • DOI 10.1016/j.canlet.2005.06.028, PII S0304383505005872
    • M. Bogusiewicz, A. Semczuk, and M. Gogacz Lack of correlation between leptin receptor expression and PI3-K/Akt signaling pathway proteins immunostaining in endometrioid-type endometrial carcinomas Cancer Lett 238 2006 61 68 (Pubitemid 43851145)
    • (2006) Cancer Letters , vol.238 , Issue.1 , pp. 61-68
    • Bogusiewicz, M.1    Semczuk, A.2    Gogacz, M.3    Skomra, D.4    Jakowicki, J.A.5    Rechberger, T.6
  • 16
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • DOI 10.1158/0008-5472.CAN-05-2620
    • K. Oda, D. Stokoe, Y. Taketani, and F. McCormick High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma Cancer Res 65 2005 10669 10673 (Pubitemid 41713332)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 18
    • 67349170390 scopus 로고    scopus 로고
    • Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
    • M.P. Hayes, W. Douglas, and L.H. Ellenson Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma Gynecol Oncol 113 2009 370 373
    • (2009) Gynecol Oncol , vol.113 , pp. 370-373
    • Hayes, M.P.1    Douglas, W.2    Ellenson, L.H.3
  • 19
    • 77950819136 scopus 로고    scopus 로고
    • The analysis of PIK3CA mutations in gastric carcinoma and meta-analysis of literature suggest that exon-selectivity is a signature of cancer type
    • S. Barbi, I. Cataldo, and G. De Manzoni The analysis of PIK3CA mutations in gastric carcinoma and meta-analysis of literature suggest that exon-selectivity is a signature of cancer type J Exp Clin Cancer Res 29 2010 32
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 32
    • Barbi, S.1    Cataldo, I.2    De Manzoni, G.3
  • 20
    • 54249159640 scopus 로고    scopus 로고
    • PIK3CA cooperates with other phosphatidylinositol 3′-kinase pathway mutations to effect oncogenic transformation
    • K. Oda, J. Okada, and L. Timmerman PIK3CA cooperates with other phosphatidylinositol 3′-kinase pathway mutations to effect oncogenic transformation Cancer Res 68 2008 8127 8136
    • (2008) Cancer Res , vol.68 , pp. 8127-8136
    • Oda, K.1    Okada, J.2    Timmerman, L.3
  • 21
    • 67649382929 scopus 로고    scopus 로고
    • AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
    • K.M. Vasudevan, D.A. Barbie, and M.A. Davies AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer Cancer Cell 16 2009 21 32
    • (2009) Cancer Cell , vol.16 , pp. 21-32
    • Vasudevan, K.M.1    Barbie, D.A.2    Davies, M.A.3
  • 22
    • 78149473552 scopus 로고    scopus 로고
    • Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
    • C.J. Creighton, X. Fu, and B.T. Hennessy Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer Breast Cancer Res 12 2010 R40
    • (2010) Breast Cancer Res , vol.12 , pp. 40
    • Creighton, C.J.1    Fu, X.2    Hennessy, B.T.3
  • 23
    • 33846557325 scopus 로고    scopus 로고
    • Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma
    • DOI 10.1007/s10549-006-9295-8
    • E. Tokunaga, E. Oki, and Y. Kimura Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma Breast Cancer Res Treat 101 2007 249 257 (Pubitemid 46169878)
    • (2007) Breast Cancer Research and Treatment , vol.101 , Issue.3 , pp. 249-257
    • Tokunaga, E.1    Oki, E.2    Kimura, Y.3    Yamanaka, T.4    Egashira, A.5    Nishida, K.6    Koga, T.7    Morita, M.8    Kakeji, Y.9    Maehara, Y.10
  • 24
    • 0028889465 scopus 로고
    • Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: Correlation with overall survival
    • B. Saffari, L.A. Jones, and A. el-Naggar Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival Cancer Res 55 1995 5693 5698
    • (1995) Cancer Res , vol.55 , pp. 5693-5698
    • Saffari, B.1    Jones, L.A.2    El-Naggar, A.3
  • 26
    • 71049146802 scopus 로고    scopus 로고
    • Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
    • P. Dong, Z. Xu, and N. Jia Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway Mol Cancer 8 2009 103
    • (2009) Mol Cancer , vol.8 , pp. 103
    • Dong, P.1    Xu, Z.2    Jia, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.