C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4790-4800

  Chen, Yue Lei ^a,b   Zacharias, Jeana ^a   Vince, Robert ^a   Geraghty, Robert J ^a   Wang, Zhengqiang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

6 Aryl 4 quinolone 3 carboxylic acids; Hepatitis C virus inhibitors; NS5B polymerase

Indexed keywords

1 (2 HYDROXYETHYL) 6 (4 ACETYLTHIOPHEN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 (4 METHOXYPHENYL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 (BENZO[B]FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 (BENZO[B]THIOPHEN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 (FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 (FURAN 3 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 (THIOPHEN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 6 IODO 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 7 (BENZO[B]FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 7 (FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (2 HYDROXYETHYL) 7 (THIPHEN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (3 HYDROXYPROPYL) 6 (BENZO[B]FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 (3 HYDROXYPROPYL) 7 (THIPHEN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 BENZYL 6 IODO 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 1 PROPYL 6 (BENZO[B]FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 2' C METHYL ADENOSINE; 6 (FURAN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 6 (THIOPHEN 2 YL) 4 OXO QUINOLINE 3 CARBOXYLIC ACID; 6 IODO 4 OXO QUINOLINE 3 CARBOXYLIC ACID; ANTIVIRUS AGENT; ARYL SUBSTITUTED 4 QUINOLONE 3 CARBOXYLIC ACID DERIVATIVE; ETHYL 6 IODO 4 OXO 1H QUINOLINE 3 CARBOXYLIC ACID; ETHYL 7 BROMO 4 OXO 1H QUINOLINE 3 CARBOXYLIC ACID; ETHYL ALPHA CARBETHOXY BETA 3 BROMOANILINOACRYLIC ACID; ETHYL ALPHA CARBETHOXY BETA 4 IODOANILINOACRYLIC ACID; NONSTRUCTURAL PROTEIN 5B; PROTEIN INHIBITOR; RIBAVIRIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; PHARMACOPHORE; REPLICON; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VIRUS INHIBITION;

4-QUINOLONES; ANTIVIRAL AGENTS; CARBOXYLIC ACIDS; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; REAL-TIME POLYMERASE CHAIN REACTION; REPLICON; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84863986134     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.066     Document Type: Article

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