Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 2, 2012, Pages

  Cubero, Francisco Javier ^a,b   Nieto, Natalia ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Alcoholic liver disease; Antioxidants; Early growth response 1; Extracellular signal regulated kinase; Oxidative stress; Polyunsaturated fatty acids; Reduced nicotinamide adenine dinucleotide phosphatase oxidase; Tumor necrosis factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE TRIPHOSPHATE; ALCOHOL; ARACHIDONIC ACID; EARLY GROWTH RESPONSE FACTOR 1; HYDROPEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; KUPFFER CELL; LIPID PEROXIDATION; LIVER INJURY; METABOLIC PARAMETERS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; ARACHIDONIC ACID; CELL PROLIFERATION; CURCUMIN; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; FLAVONOIDS; HUMANS; KUPFFER CELLS; LIPID PEROXIDATION; LIVER; LIVER DISEASES, ALCOHOLIC; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863979879     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00465.2011     Document Type: Article

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