Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes

Drug Metabolism and Disposition

Volumn 38, Issue 1, 2010, Pages 133-142

  Grillo, Mark P ^a   Wait, Jill C M ^a   Lohr, Michelle Tadano ^a   Khera, Smriti ^a   Benet, Leslie Z ^b  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; FLUNOXAPROFEN; GLUTATHIONE; LAURIC ACID; THIOESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY; TANDEM MASS SPECTROMETRY;

ACYL COENZYME A; ACYLATION; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOXAZOLES; BIOCATALYSIS; BIOTRANSFORMATION; BORNANES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; ESTERS; GLUCURONIC ACID; GLUTATHIONE; HEPATOCYTES; IBUPROFEN; KINETICS; LAURIC ACIDS; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; SULFHYDRYL COMPOUNDS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 73149114171     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.029371     Document Type: Article

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