Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes

Drug Metabolism and Disposition

Volumn 37, Issue 5, 2009, Pages 1073-1082

  Grillo, Mark P ^a   Lohr, Michelle Tadano ^a,b  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; DRUG METABOLITE; GLUTATHIONE; LAURIC ACID; PHENYLACETIC ACID; PHENYLACETYL S ACYL COENZYME A THIOESTER; PHENYLACETYLACYLGLUCURONIDE; PHENYLACETYLACYLGLUTATHIONE; PHENYLACETYLGLYCINE AMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; COVALENT BOND; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; MOLECULAR WEIGHT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BIOTRANSFORMATION; CELL SEPARATION; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE; HEPATOCYTES; LAURIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MOLECULAR WEIGHT; PHENYLACETATES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 66449102106     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.026153     Document Type: Article

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