Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: Thiol ester hydrolysis and inhibitor maturation

Archives of Biochemistry and Biophysics

Volumn 414, Issue 2, 2003, Pages 303-311

  Ibarra, Catherine ^a   Grillo, Mark P ^b   Lo Bello, Mario ^c   Nucettelli, Marzia ^c   Bammler, Theo K ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Cancer chemotherapy; Enzyme inhibitors; Futile cycling; Glutathione adducts; Glutathione pro drugs

Indexed keywords

DICLOFENAC S ACYLGLUTATHIONE; ENZYME INHIBITOR; ETACRYNIC ACID; ETHACRYNIC ACID S ACYLGLUTATHIONE; FLURBIPROFEN S ACYLGLUTATHIONE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; ISOENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG; SULINDAC S ACYLGLUTATHIONE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; DISSOCIATION; DRUG ACTIVATION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE; HYDROLYSIS; IN VITRO STUDY; MODEL; PRIORITY JOURNAL;

EID: 0038440457     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(03)00198-X     Document Type: Article

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