Gene expression profiling in alzheimer's disease brain microvessels

Journal of Alzheimer's Disease

Volumn 31, Issue 1, 2012, Pages 193-205

  Wang, Shu ^a,b   Qaisar, Uzma ^c   Yin, Xiangling ^a   Grammas, Paula ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b TEXAS TECH UNIVERSITY   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; brain; gene expression profile; microarray; microvessel

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE REPLICATION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFLAMMATION; MALE; MICROARRAY ANALYSIS; MICROVASCULATURE; NERVOUS SYSTEM DEVELOPMENT; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 84863938664     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120454     Document Type: Article

References (88)

1. Alzheimer's Association (2012) Alzheimer's facts and figures, http://www. alz.org/alzheimers disease facts and figures.asp.
2. Ruitenberg A, den Heijer T, Bakker SL, van Swieten JC, Koudstaal PJ, Hofman A, Breteler MM (2005) Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam Study. Ann Neurol 57, 789-794. (Pubitemid 40798616)
3. Strittmatter JW, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipopro-tein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90, 1977-1981. (Pubitemid 23069980)
4. Hofman A, Ott A, Breteler MM, Bots ML, Slooter AJ, van Harskamp F, van Duijn CN, Van Broeckhoven C, Grobbee DE (1997) Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 349, 151-154. (Pubitemid 27039193)
5. Miller JW (1999) Homocysteine and Alzheimer's disease. Nutr Rev 57, 126-129. (Pubitemid 29206388)
6. Shi J, Perry G, Smith MA, Friedland RP (2000) Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease. Neurobiol Aging 21, 357-361. (Pubitemid 30387095)
7. Sparks DL, Martin TA, Gross DR, Hunsaker JC III (2000) Link between heart disease, cholesterol and Alzheimer's disease: A review. Microsc Res Tech 50, 287-290. (Pubitemid 30651168)
8. Marx J (2001) Alzheimer's disease. Bad for the heart, bad for the mind? Science 294, 508-509.
9. Rhodin JA, Thomas T (2001) A vascular connection to Alzheimer's disease. Microcirculation 8, 207-220. (Pubitemid 33598127)
10. de la Torre JC (2002) Alzheimer diseaseasavascular disorder: Nosological evidence. Stroke 3, 1152-1162.
11. Pansari K, Gupta A, Thomas P (2002) Alzheimer's disease and vascular factors: Facts and theories. Int J Clin Pract 56, 197-203. (Pubitemid 34477203)
12. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolff PA (2002) Plasma homo-cysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346, 476-483. (Pubitemid 34441738)
13. Miyakawa T, Shimoj IA, Kuramoto R, Higuchi Y (1982) The relationship between senile plaquesand cerebral bloodvessels in Alzheimer's disease and senile dementia. Morphological mechanism ofsenile plaque production. Virchows Arch B Cell Pathol Incl Mol Pathol 40, 121-129. (Pubitemid 12056763)
14. Miyakawa T (1997) Electron microscopy of amyloid fibrils and microvessels. Ann NY Acad Sci 826, 25-34. (Pubitemid 27478028)
15. Fischer VW, Siddiqi A, Yusufaly Y (1990) Altered angioar- chitectureinselected areasofbrains with Alzheimer's disease. Acta Neuropathol 79, 672-679. (Pubitemid 20170345)
16. Buée L, Hof PR, Bouras C, Delacourte A, Perl DP, Morrison JH, Fillit HM (1994) Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathol 87, 469-480. (Pubitemid 24128974)
17. Marchesi VT (2011) Alzheimer's dementia beginsasadisease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: Implications for early detection and therapy. FASEB J 25, 5-13.
18. Grammas P (2010) A damaged microcirculation contributes to neuronal cell deathinAlzheimer's disease. Neurobiol Aging 21, 199-205.
19. Pimplikar SW (2009) Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int J Biochem Cell Biol 41, 1261-1268.
20. Karran E, Mercken M, DeStrooper B (2011) The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics. Nat Rev Drug Discov 10, 698-712.
21. Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, Landfield PW (2005) Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: Statistical reliability and functional correlation. Ageing Res Rev 4, 481-512. (Pubitemid 43293164)
22. Tan MG, Chua WT, Esiri MM, Smith AD, Vinters HV, Lai MK (2010) Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease. J Neurosci Res 88, 1157-1169.
23. Arisi I, D'Onofrio M, Brandi R, Felsani A, Capsoni S, Drovandi G, Felici G, Weitschek E, Bertolazzi P, Cattaneo A (2011) Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: Mining of microarray data by Logic classification and feature selection. J Alzheimers Dis 24, 721-738.
24. Ball MJ, Griffin-Brooks S, MacGregor JA, Ojalvo-Rose E, Fewster PH (1998) Neuropathological definition of Alzheimer disease: Multivariate analysesinthe morphometric distinction between Alzheimer dementia and normal aging. Alzheimer Dis Assoc Disord 2, 29-37.
25. Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42, 1097-1105. (Pubitemid 16236926)
26. Grammas P, Moore P, Weigel PH (1999) Microvessels from Alzheimer's disease brains kill neurons in vitro. Am J Pathol 154, 337-342. (Pubitemid 29094084)
27. Ginsberg SD, Hemby SE, Lee VM, Eberwine JH, Trojanowski JH (2000) Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann Neurol 48, 77-87. (Pubitemid 30432434)
28. Loring JF, Wen X, Lee JM, Seihamer J, Somogyi R (2001) A gene expression profile of Alzheimer's disease. DNA Cell Biol 20, 683-695. (Pubitemid 34072835)
29. Pasinetti GM (2001) Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia. J Neurosci Res 65, 471-476. (Pubitemid 32847139)
30. Colangelo V, Schurr J, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ (2002) Gene expression profiling of 12633 genes in Alzheimer hipppocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J Neurosci Res 70, 462-473. (Pubitemid 35222383)
31. Yao PJ, Zhu M, Pyun EI, Brooks AI, Therianos S, Meyers VE, Coleman PD (2003) Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol Dis 12, 97-109. (Pubitemid 36355860)
32. Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW (2004) Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci USA 101, 2173-2178. (Pubitemid 38229034)
33. Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA (2008) Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: A reference data set. Physiol Genomics 33, 240-256. (Pubitemid 351629532)
34. Blalock EM, Buechel HM, Popovic J, Geddes JW, Landfield PW (2011) Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signature associated with incipient Alzheimer's disease. J Chem Neuroanat 42, 118-126.
35. George AJ, Gordon L, Beissbarth T, Koukoulas I, Holsinger RM, Perreau V, Cappai R, Tan SS, Masters CL, Scott HS, Li QX (2010) A serial analysis of gene expression profile of Alzheimer's disease Tg2576 mouse model. Neurotox Res 17, 360-379.
36. Tseveleki V, Rubio R, Vamvakas SS, White J, Taoufik E, Petit E, Quackenbush J, Probert L (2010) Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated disease-specific gene changes. Genomics 96, 82-91.
37. Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Gar-wood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB (2011) MRC Cognitive Function and Ageing Neuropathology Study Group, Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype. Neurobiol Aging 32, 1795-1807.
38. Dorheim MA, Tracey WR, Pollock JS, Grammas P (1994) Nitric oxide is elevated in Alzheimer's brain microvessels. Biochem Biophys Res Comm 205, 659-665. (Pubitemid 24381677)
39. Grammas P, Ovase R (2001) Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol Aging 22, 837-842. (Pubitemid 34066550)
40. Grammas P, Ovase R (2002) Cerebrovascular TGF-β contributes to inflammation in the Alzheimer's brain. Am J Pathol 160, 1583-1587. (Pubitemid 34525638)
41. Grammas P, Samany PG, Thirumangalakudi L (2006) Throm-bin and inflammatory proteins are elevated in Alzheimer's disease microvessels: Implications for disease pathogenesis. JAlzheimers Dis 9, 51-58.
42. Thirumangalakudi L, Samany PG, Owoso A, Wiskar B, Grammas P (2006) Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease. J Alzheimers Dis 10, 111-118. (Pubitemid 44401371)
43. Grammas P (2011) Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation 8, 26.
44. Grammas P, Martinez J, Miller B (2011) Cerebral microvas-cular endothelium and the pathogenesis of neurodegenerative diseases. Expert Rev Mol Med 13, e19.
45. Grammas P, Sanchez A, Tripathy D, Luo E, Martinez J (2011) Vascular signaling abnormalities in Alzheimer disease. Cleve Clin J Med 78, S50-S53.
46. Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5, 347-360. (Pubitemid 38568496)
47. Zlokovic BV (2005) Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 28, 202-208. (Pubitemid 40445527)
48. Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118, 103-113.
49. Altman R, Rutledge JC (2010) The vascular contribution to Alzheimer's disease. Clin Sci (Lond) 119, 407-421.
50. de la Torre JC (2010) The vascular hypothesis of Alzheimer's disease: Bench to bedside and beyond. Neurodegener Dis 7, 116-121.
51. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934.
52. Cooper NR, Bradt BM, O'Barr S, Yu JX (2000) Focal inflammation in the brain: Role in Alzheimer's disease? Immunol Res 21, 159-165.
53. Neuroinflammation Working Group (2000) Inflammation and alzheimer's disease. Neurobiol Aging 21, 383-421.
54. Tarkowski E (2002) Cytokines in dementia. Curr Drug Targets Inflamm Allergy 1, 193-200.
55. McGeer EG, McGeer PL (2003) Inflammatory processes in Alzheimer's disease. Prog Neuropsycholpharmacol Biol Psychiatry 27, 741-749. (Pubitemid 36966754)
56. McGeer EG, McGeer PL (2004) Inflammation and the degenerative diseases of aging. Ann NY Acad Sci 1035, 104-116. (Pubitemid 40362329)
57. Ho GJ, Drego R, Hakimian E, Masliah E (2005) Mechanisms of cell signaling and inflammation in Alzheimer's disease. Curr Drug Targets Inflamm Allergy 4, 247-256. (Pubitemid 40873107)
58. Wyss-Coray T (2006) Inflammation in Alzheimer disease: Driving force, bystander or beneficial response? Nat Med 12, 1005-1015. (Pubitemid 44353380)
59. Lee YJ, Han SB, Nam SY, Oh KW, Hong JT (2010) Inflammation and Alzheimer's disease. Arch Pharm Res 33, 1539-1556.
60. Yin X, Wright J, Wall T, Grammas P (2010) Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. Am J Pathol 176, 1600-1606.
61. Balistreri CR, Caruso C, Grimaldi MP, List̀i F, Vasto S, Orlando V, Campagna AM, Lio D, Candore G (2007) CCR5 receptor: Biologic and gentic implications in age-related diseases. Ann N Y Acad Sci 1100, 162-172. (Pubitemid 47092648)
62. Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto JB (2009) Role of macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide. Am J Pathol 175, 1586-1597.
63. Savarin-Vuaillat C, Ransohoff RM (2007) Chemokines and chemokine receptors in neurological disease: Raise, retain, or reduce? Neurotherapeutics 4, 590-601. (Pubitemid 47499286)
64. Vukic V, Callaghan D, Walker D, Lue LF, Liu QY, Couraud PO, Romero IA, Weksler B, Stanimirovic DB, Zhang W (2009) Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. Neurobiol Dis 34, 95-106.
65. Richardson RM, Pridgen BC, Haribabu B, Snyderman R (2000) Regulation of the human chemokine CCR1. Cross-regulation by CXCR1 and CXCR2. J Biol Chem 275, 9201-9208. (Pubitemid 30185137)
66. Davidson B, Dong HP, Holth A, Berner A, Risberg B (2007) Chemokine receptors are infrequently expressed in maglig-nant and benign mesothelial cells. Am J Clin Pathol 127, 752-759.
67. Xia MQ, Hyman BT (1999) Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. J Neurovirol 5, 32-41. (Pubitemid 29051876)
68. Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST (2008) Increased 5-lipoxygenase immunoreactivity in the hippocampous of patients with Alzheimer's disease. J His-tochem Cytochem 56, 1065-1073.
69. Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Pratico D (2008) 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in mouse model of Alzheimer's disease. FASEB J 22, 1169-1178. (Pubitemid 351519971)
70. Chu J, Pratico D (2011) 5-Lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann Neurol 69, 34-46.
71. Crews L, Masliah E (2010) Molecular mechanisms of neu-rodegeneration in Alzheimer's disease. Hum Mol Genet 19, R12-R20.
72. Stornetta RL, Zhu JJ (2011) Ras and rap signaling in synaptic plasticity and mental disorders. Neuroscientist 17, 54-78.
73. Schlüter OM, Basu J, Südhof TC, Rosenmund C (2006) Rab3 superprimes synaptic vesicles for release: Implications for short-term synaptic plasticity. J Neurosci 26, 1239-1246. (Pubitemid 43237056)
74. Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC (2011) Rab3 protein is required for long term-depression of hippocampal inhibitory synapses for normal reversal learning. Proc Natl Acad Sci USA 108, 14300-14305.
75. Knop M, Aareskjold E, Bode G, Gerke V (2004) Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. EMBO J 23, 2982-2992. (Pubitemid 39093592)
76. Reddy PH, Mani G, Park BS, Jacques J, Murdoch G, Whetsell W Jr, Kaye J, Manczak M (2005) Differential loss of synap-tic proteins in Alzheimers disease: Implications for synaptic dysfunction. J Alzheimers Dis 7, 103-117. (Pubitemid 40592184)
77. Proctor DT, Coulson EJ, Dodd PR (2011) Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimers disease. Prog Neurobiol 93, 509-521.
78. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (1992) Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science 256, 1217-1221.
79. Solhonne B, Gros C, Pollard H, Schwartz JC (1987) Major localization of aminopeptidase M in rat brain microvessels. Neuroscience 22, 225-232. (Pubitemid 17106770)
80. Parfenova H, Fedinec A, Leffler CW (2003) Ionotropic glu-tamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase. J Cereb Blood Flow Metab 23, 190-197. (Pubitemid 36188457)
81. St'astný F, Lisý V, Mares V, Lisá V, Balcar VJ, Santamaŕia A (2004) Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels. Redox Rep 9, 229-233.
82. Carmeliet P (2003) Blood vessels and nerves: Common signals, pathways and diseases. Nat Rev Genet 4, 710-720. (Pubitemid 37046138)
83. Arese M, Serini G, Bussolino F (2011) Nervous vascular parallels: Axon guidance and beyond. Int J Dev Biol 55, 439-445.
84. Quaegebeur A, Lange C, Carmeliet P (2011) The neurovas-cular link in health and disease: Molecular mechanisms and therapeutic implications. Neuron 71, 406-424.
85. Kallmann BA, Wagner S, Hummel V, Buttmann M, Bayas A, Tonn JC, Rieckmann P (2002) Characteristic gene expression profile of primary human cerebral endothelial cells. FASEB J 16, 589-591.
86. Apel PJ, Ma J, Callahan M, Northam CN, Alton TB, Son-ntag WE, Li Z (2010) Effect of locally delivered IGF-1 on nerve regeneration during aging: An experimental study in rats. Muscle Nerve 41, 335-341.
87. Foster PP, Rosenblatt KP, Kuljis RO (2011) Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease. Front Neurol 2, 28.
88. Ward NL, LaManna JC (2004) The neurovascular unit and its growth factors: Coordinated response in the vascular and nervous systems. Neurol Res 26, 870-883. (Pubitemid 39628565)