-
1
-
-
79961135233
-
Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3)
-
Astorga B, Wunz TM, Morales M, Wright SH, Pelis RM. Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3). Am J Physiol Renal Physiol 301: F378-F386, 2011.
-
(2011)
Am J Physiol Renal Physiol
, vol.301
-
-
Astorga, B.1
Wunz, T.M.2
Morales, M.3
Wright, S.H.4
Pelis, R.M.5
-
2
-
-
84857737656
-
The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization
-
Brast S, Grabner A, Sucic S, Sitte HH, Hermann E, Pavenstadt H, Schlatter E, Ciarimboli G. The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization. FASEB J 26: 976-986, 2012.
-
(2012)
FASEB J
, vol.26
, pp. 976-986
-
-
Brast, S.1
Grabner, A.2
Sucic, S.3
Sitte, H.H.4
Hermann, E.5
Pavenstadt, H.6
Schlatter, E.7
Ciarimboli, G.8
-
3
-
-
0034703068
-
Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat
-
Budiman T, Bamberg E, Koepsell H, Nagel G. Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat. J Biol Chem 275: 29413-29420, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 29413-29420
-
-
Budiman, T.1
Bamberg, E.2
Koepsell, H.3
Nagel, G.4
-
4
-
-
12644278786
-
Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1
-
Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem 271: 32599-32604, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 32599-32604
-
-
Busch, A.E.1
Quester, S.2
Ulzheimer, J.C.3
Waldegger, S.4
Gorboulev, V.5
Arndt, P.6
Lang, F.7
Koepsell, H.8
-
5
-
-
77649216536
-
Membrane transporters in drug development
-
Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. Membrane transporters in drug development. Nat Rev Drug Discov 9: 215-236, 2010.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 215-236
-
-
Giacomini, K.M.1
Huang, S.M.2
Tweedie, D.J.3
Benet, L.Z.4
Brouwer, K.L.5
Chu, X.6
Dahlin, A.7
Evers, R.8
Fischer, V.9
Hillgren, K.M.10
Hoffmaster, K.A.11
Ishikawa, T.12
Keppler, D.13
Kim, R.B.14
Lee, C.A.15
Niemi, M.16
Polli, J.W.17
Sugiyama, Y.18
Swaan, P.W.19
Ware, J.A.20
Wright, S.H.21
Yee, S.W.22
Zamek-Gliszczynski, M.J.23
Zhang, L.24
more..
-
6
-
-
17844385032
-
Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region
-
Gorboulev V, Shatskaya N, Volk C, Koepsell H. Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region. Mol Pharmacol 67: 1612-1619, 2005.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1612-1619
-
-
Gorboulev, V.1
Shatskaya, N.2
Volk, C.3
Koepsell, H.4
-
7
-
-
0032723798
-
Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate
-
Gorboulev V, Volk C, Arndt P, Akhoundova A, Koepsell H. Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate. Mol Pharmacol 56: 1254-1261, 1999.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1254-1261
-
-
Gorboulev, V.1
Volk, C.2
Arndt, P.3
Akhoundova, A.4
Koepsell, H.5
-
8
-
-
27744459366
-
Identification of intra-and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2
-
Henriksen U, Fog JU, Litman T, Gether U. Identification of intra-and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2. J Biol Chem 280: 36926-36934, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 36926-36934
-
-
Henriksen, U.1
Fog, J.U.2
Litman, T.3
Gether, U.4
-
9
-
-
0032569029
-
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
-
Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273: 15971-15979, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 15971-15979
-
-
Kekuda, R.1
Prasad, P.D.2
Wu, X.3
Wang, H.4
Fei, Y.J.5
Leibach, F.H.6
Ganapathy, V.7
-
10
-
-
80054801694
-
The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization
-
Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dotsch V, Hunte C, Sitte HH, Koepsell H. The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. J Biol Chem 286: 37874-37886, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 37874-37886
-
-
Keller, T.1
Egenberger, B.2
Gorboulev, V.3
Bernhard, F.4
Uzelac, Z.5
Gorbunov, D.6
Wirth, C.7
Koppatz, S.8
Dotsch, V.9
Hunte, C.10
Sitte, H.H.11
Koepsell, H.12
-
11
-
-
3042569768
-
Polyspecific organic cation transporters: Their functions and interactions with drugs
-
Koepsell H. Polyspecific organic cation transporters: their functions and interactions with drugs. Trends Pharmacol Sci 25: 375-381, 2004.
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 375-381
-
-
Koepsell, H.1
-
12
-
-
34249943356
-
Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
-
Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24: 1227-1251, 2007.
-
(2007)
Pharm Res
, vol.24
, pp. 1227-1251
-
-
Koepsell, H.1
Lips, K.2
Volk, C.3
-
13
-
-
0025761101
-
+-D-glucose cotransport in human intestinal brush-border membrane vesicles using a fast sampling, rapid filtration apparatus
-
+-D-glucose cotransport in human intestinal brush-border membrane vesicles using a fast sampling, rapid filtration apparatus. J Membr Biol 122: 127-141, 1991.
-
(1991)
J Membr Biol
, vol.122
, pp. 127-141
-
-
Malo, C.1
Berteloot, A.2
-
14
-
-
0036205460
-
Gene expression levels and immunolocalization of organic ion transporters in the human kidney
-
Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui KI. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13: 866-874, 2002.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 866-874
-
-
Motohashi, H.1
Sakurai, Y.2
Saito, H.3
Masuda, S.4
Urakami, Y.5
Goto, M.6
Fukatsu, A.7
Ogawa, O.8
Inui, K.I.9
-
15
-
-
78649646556
-
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy
-
Nies AT, Koepsell H, Damme K, Schwab M. Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Hand Exp Pharmacol 201: 105-167, 2011.
-
(2011)
Hand Exp Pharmacol
, vol.201
, pp. 105-167
-
-
Nies, A.T.1
Koepsell, H.2
Damme, K.3
Schwab, M.4
-
16
-
-
34247849190
-
Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity
-
Pelis RM, Dangprapai Y, Wunz TM, Wright SH. Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity. Am J Physiol Renal Physiol 292: F1583-F1591, 2007.
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Pelis, R.M.1
Dangprapai, Y.2
Wunz, T.M.3
Wright, S.H.4
-
17
-
-
33646565671
-
Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport
-
Pelis RM, Suhre WM, Wright SH. Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport. Am J Physiol Renal Physiol 290: F1118-F1126, 2006.
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Pelis, R.M.1
Suhre, W.M.2
Wright, S.H.3
-
18
-
-
33845922107
-
Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2
-
Pelis RM, Zhang X, Dangprapai Y, Wright SH. Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2. J Biol Chem 281: 35272-35280, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 35272-35280
-
-
Pelis, R.M.1
Zhang, X.2
Dangprapai, Y.3
Wright, S.H.4
-
19
-
-
84862176841
-
Renal transport of organic anions and cations
-
In, Hoboken, NJ: John Wiley & Sons
-
Pelis RM, Wright SH. Renal transport of organic anions and cations. In: Comprehensive Physiology. Hoboken, NJ: John Wiley & Sons, 2011.
-
(2011)
Comprehensive Physiology
-
-
Pelis, R.M.1
Wright, S.H.2
-
20
-
-
33846010171
-
A three-dimensional model of human organic anion transporter 1: Aromatic amino acids required for substrate transport
-
Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB. A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem 281: 38071-38079, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 38071-38079
-
-
Perry, J.L.1
Dembla-Rajpal, N.2
Hall, L.A.3
Pritchard, J.B.4
-
21
-
-
17644411713
-
Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease
-
Popp C, Gorboulev V, Muller T, Gorbunov D, Shatskaya N, Koepsell H. Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol Pharmacol 67: 1600-1611, 2005.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1600-1611
-
-
Popp, C.1
Gorboulev, V.2
Muller, T.3
Gorbunov, D.4
Shatskaya, N.5
Koepsell, H.6
-
22
-
-
0029902695
-
Renal secretion of organic anions and cations
-
Pritchard JB, Miller DS. Renal secretion of organic anions and cations. Kidney Int 49: 1649-1654, 1996.
-
(1996)
Kidney Int
, vol.49
, pp. 1649-1654
-
-
Pritchard, J.B.1
Miller, D.S.2
-
23
-
-
34548645392
-
Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity
-
Sturm A, Gorboulev V, Gorbunov D, Keller T, Volk C, Schmitt BM, Schlachtbauer P, Ciarimboli G, Koepsell H. Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. Am J Physiol Renal Physiol 293: F767-F779, 2007.
-
(2007)
Am J Physiol Renal Physiol
, vol.293
-
-
Sturm, A.1
Gorboulev, V.2
Gorbunov, D.3
Keller, T.4
Volk, C.5
Schmitt, B.M.6
Schlachtbauer, P.7
Ciarimboli, G.8
Koepsell, H.9
-
24
-
-
2642564429
-
Cysteine residues in the organic anion transporter mOAT1
-
Tanaka K, Zhou F, Kuze K, You G. Cysteine residues in the organic anion transporter mOAT1. Biochem J 380: 283-287, 2004.
-
(2004)
Biochem J
, vol.380
, pp. 283-287
-
-
Tanaka, K.1
Zhou, F.2
Kuze, K.3
You, G.4
-
25
-
-
34447118244
-
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates
-
Umehara KI, Iwatsubo T, Noguchi K, Kamimura H. Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: insight into the development of drug candidates. Xenobiotica 37: 618-634, 2007.
-
(2007)
Xenobiotica
, vol.37
, pp. 618-634
-
-
Umehara, K.I.1
Iwatsubo, T.2
Noguchi, K.3
Kamimura, H.4
-
26
-
-
17444421115
-
Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics
-
Wright SH. Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics. Toxicol Appl Pharmacol 204: 309-319, 2005.
-
(2005)
Toxicol Appl Pharmacol
, vol.204
, pp. 309-319
-
-
Wright, S.H.1
-
27
-
-
27144555426
-
A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2)
-
Zhang X, Shirahatti NV, Mahadevan D, Wright SH. A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2). J Biol Chem 280: 34813-34822, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 34813-34822
-
-
Zhang, X.1
Shirahatti, N.V.2
Mahadevan, D.3
Wright, S.H.4
|