Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training

Cell Biochemistry and Function

Volumn 28, Issue 4, 2010, Pages 306-312

  Huuskonen, Antti ^a   Lappalainen, Jani ^a   Tanskanen, Minna ^b   Oksala, Niku ^a,c   Kyröläinen, Heikki ^b   Atalay, Mustafa ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

BMI; Exercise; Leptin; SNP

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

ADULT; ALLELE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; EXERCISE; GENETIC VARIABILITY; HETEROZYGOTE; HOMOZYGOTE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SOLDIER; TRAINING;

ALLELES; BODY COMPOSITION; BODY MASS INDEX; EXERCISE; GENOTYPE; HOMOZYGOTE; HUMANS; LEPTIN; MALE; OXYGEN CONSUMPTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, LEPTIN; YOUNG ADULT;

EID: 77953496568     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1658     Document Type: Article

References (36)

1. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770. doi:10.1038/27376 (Pubitemid 28485436)
2. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897-901. doi:10.1038/29795 (Pubitemid 28410912)
3. Gainsford T, Willson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A 1996; 93: 14564-14568.
4. Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998; 83: 1059-1066.
5. Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683-1686.
6. Gallardo N, Bonzon-Kulichenko E, Fernandez-Agullo T, et al. Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology 2007; 148: 5604-5610. doi:10.1210/en.2007-0933 (Pubitemid 350146140)
7. Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sports Med. 2008 Oct 16. [Epub ahead of print] doi:10.1136/bjsm.2008.046151
8. Brookes AJ. The essence of SNPs. Gene 1999; 234: 177-186.
9. Macarthur DG, North KN. Genes and human elite athletic performance. Hum Genet 2005; 116: 331-339. doi:10.1007/s00439-005-1261-8 (Pubitemid 40521108)
10. Huuskonen A, Tanskanen M, Lappalainen J, Oksala N, Kyröläinen H, Atalay M. A common variation in the promoter region of interleukin-6 gene shows association with exercise performance. J Sports Sci Med 2009; 8: 271-277.
11. Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.
12. Mammes O, Betoulle D, Aubert R, Herbeth B, Siest G, Fumeron F. Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Ann Hum Genet 2000; 64: 391-394.
13. Masuo K, Straznicky NE, Lambert GW, et al. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res 2008; 31: 1093-1100.
14. Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 2002; 34: 355-359. doi:10.1055/s-2002-33466
15. Wang TN, Huang MC, Chang WT, et al. G-2548A polymorphismof the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring) 2006; 14: 183-187. doi:10.1038/oby.2006.23
16. Ali SB, Kallel A, Ftouhi B, et al. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin Biochem 2009; 42: 584-588.
17. Loos RJ, Rankinen T, Chagnon Y, Tremblay A, Perusse L, Bouchard C. Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Quebec Family Study. Int J of Obes (Lond) 2005; 30: 183-190. doi:10.1038/sj.ijo.0803127
18. Wauters M, Considine RV, Chagnon M, et al. Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women. Obes Res 2002; 10: 394-400. doi:10.1038/oby.2002.54
19. Stefan N, Vozarova B, Del Parigi A, et al. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int J Obes Relat Metab Disord 2002; 26: 1629-1632. doi:10.1038/sj.ijo.0802161 (Pubitemid 36099011)
20. Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a HuGE review. Am J Epidemiol 2005; 162: 101-114. doi:10.1093/aje/kwi174 (Pubitemid 41373535)
21. Jurimae J, Maestu J, Jurimae T. Leptin as a marker of training stress in highly trained male rowers? Eur J Appl Physiol 2003; 90: 533-538. doi:10.1007/s00421-003-0879-2 (Pubitemid 37508858)
22. Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002; 415: 339-343. doi:10.1038/415339a (Pubitemid 34087557)
23. Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A. Leptin as a cardiac hypertrophic factor: a potential target for therapeutics. Trends Cardiovasc Med 2007; 17: 206-211.
24. Pasman WJ, Westerterp-Plantenga MS, Saris WH. The effect of exercise training on leptin levels in obese males. Am J Physiol 1998; 274: E280-E286.
25. Perusse L, Collier G, Gagnon J, et al. Acute and chronic effects of exercise on leptin levels in humans. J Appl Physiol 1997; 83: 5-10.
26. Durnin JV, Rahaman MM. The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr 1967; 21: 681-689.
27. th ed. Lippincott Williams & Wilkins: Baltimore, 2001; 68, 117, 303.
28. Wilsey J, Scarpace PJ. Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with dietinduced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol 2004; 181: 297-306.
29. Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 2007; 100: 328-341. doi:10.1161/01.RES. 0000256090.42690.05
30. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1: 1155-1161.
31. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 2007; 56: 1005-1009. doi:10.1016/j.metabol.2007. 03.009 (Pubitemid 46890985)
32. Fairbrother UL, Tanko LB, Walley AJ, Christiansen C, Froguel P, Blakemore AI. Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. J Bone Min Res 2007; 22: 544-550. doi:10.1359/jbmr.070114 (Pubitemid 47457431)
33. Popko K, Gorska E, Wasik M, et al. Frequency of distribution of leptin receptor gene polymorphism in obstructive sleep apnea patients. J Physiol Pharmacol 2007; 58 (suppl 5): 551-561.
34. Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 2001; 108: 233-236.
35. van Rossum CT, Hoebee B, van Baak MA, Mars M, Saris WH, Seidell JC. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res 2003; 11: 377-386. doi:10.1038/oby.2003.51
36. Rosmond R, Chagnon YC, Holm G, et al. Hypertension in obesity and the leptin receptor gene locus. J Clin Endocrinol Metab 2000; 85: 3126-3131.