Evaluation of anti-proprotein convertase activity of diterpene andrographolid derived products

Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs): A New Potential Strategy in Cancer Therapy

Volumn , Issue , 2006, Pages 137-154

  Basak, Ajoy ^a   Banik, Upendra K ^b   Basak, Sarmistha ^a   Seidah, Nabil G ^c   Li, Suiyang ^b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b Bioscan Continental Inc   (Canada)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84863881921     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/1-4020-5132-8_8     Document Type: Chapter

References (58)

1. Chrétien M, Li CH (1967) Isolation, purification and characterization of c lipotropic hormpone from sheep pituitary glands. Can. J. Biochem. 45:1163-1174.
2. Steiner DF, Cunningham D, Spiegelman L, Aten B (1967) Insulin biosynthesis: Evidence for a precursor. Science. 157:697-699.
3. Deadman J (2000) Proteinase inhibitors and activators strategic targets for therapeutic intervention. J. Pept. Sci. 6:421-431.
4. Southan C (2000) Assessing the protease and protease inhibitor content of the human genome. "Proteinase inhibitors and activators: Strategic targets for therapeutic intervention", University of Oxford, 17-20.
5. Behrens G, Dejam A, Schmidt H, Balks HJ, Brabant G, Korner T, Stoll M, Schmidt RE (1999) Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors. AIDS. 13:F63-F70. (Also see: Http://www.hhs.gov/news/press/2004pres/20040516a.html and http://www.thebody.com/treat/newdrugs.html.
6. Mikolajczyk1 SD, Millar LS, Marker KM, Rittenhouse HG, Wolfert RL, Marks LS, Charlesworth MC, Tindall DJ (1999) Identification of a Novel Complex between Human Kallikrein 2 and Protease Inhibitor-6 in Prostate Cancer Tissue. Cancer Research 59:3927-3930.
7. Song XY, Zeng L, Jin W, Thompson J, Mizel DE, Lei KJ, Billinghurst RC, Poole RA, Wahl SM (1999) Secretory Leukocyte Protease Inhibitor Suppresses the Inflammation and Joint Damage of Bacterial Cell Wall-induced Arthritis. Exp Med 190:535-542. (Also see http://www.arrivapharm.com/product-copd.php).
8. Seidah NG, Chrétien M (1999) Proprotein and prohprmone convertases: A family of subtilases generating diverse bioactive polypeptides. Brain Research 848:45-62.
9. Steiner DF (1998) The proprotein Convertases. Curr Opin Chem Biol 2:31-39.
10. Thomas G (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3:753-766.
11. Sarac MS, Peinado JR, Leppla SH, Lindberg I (2004) Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 72:602-605.
12. Jean F, Thomas L, Molloy SS, Liu G, Jarvis MA, Nelson JA, Thomas G (2000) A protein-based therapeutic for human cytomegalovirus infection. Proc Nat Acad Sci USA 97:2864-2869.
13. Feldmann H, Volchkov VE, Volchkova VA, Klenk HD (1999) The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis. Arch Virol Suppl 15:159-169.
14. Zambon MC (2001) The pathogenesis of influenza in humans. Rev Med Virol 11:227-241.
15. Fugere M, Day R (2002) Inhibitors of the subtilase-like pro-protein convertases (SPCs). Curr Pharm Des 8:549-562.
16. Basak, A (2005) Proprotein Convertase inhibitors: Minireview. J. Mol. Med. 83:844-855.
17. Bassi DE, Mahloogi H, Lopez De Cicco R, Klein-Szanto A (2003) Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol 62:439-447.
18. Khatib AM, Siegfried G, Prat A, Luis J, Chretien M, Metrakos P, Seidah NG (2001) Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: Importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J Biol Chem 276:30686-30693.
19. Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, Murphy RA (2001) Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276:12660-12666.
20. Tsuji A, Hashimoto E, Ikoma T, Taniguchi T, Mori K, Nagahama M, Matsuda Y (1999) Inactivation of proprotein convertase, PACE4, by alpha1-antitrypsin Portland (alpha1-PDX), a blocker of proteolytic activation of bone morphogenetic protein during embryogenesis: Evidence that PACE4 is able to form an SDS-stable acyl intermediate with alpha1-PDX. J Biochem (Tokyo). 126:591-603.
21. Jean F, Basak A, DiMaio J, Seidah NG, Lazure C (1995) An internally quenched fluorogenic PC1 and furin substrate leads to a potent prohormone convertase inhibitor. Biochem J 307: 689-695.
22. Basak A, Schmidt C, Ismail AA, Seidah NG, Chrétien M, Lazure C (1995) Peptidyl Substrates containing Unnatural amino acid at the P'1 positio are Potent Inhibitors of Prohormone Convertases. Int J Pept Prot Res 46:228-237.
23. Jean F, Boudreault A, Basak A, Seidah NG, Lazure C (1995) Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and furin and in designing a potent irreversible inhibitor. J Biol Chem 270:19225-19231.
24. Zhong M, Munzer JS, Basak A, Benjannet S, Mowla SJ, Decroly E, Chrétien M, Seidah NG (1999) The prosegments of Furin and PC7 as potent inhibitors of proprotein convertases: In vitro and ex vivo assessment of their specificity and selectivity. J Biol Chem 274:33913-33920.
25. Basak A, Lazure C (2003) Synthetic peptides of prosegments of proprotein convertases PC1 and furin are inhibitors of both convertases with some selectivity. Biochem J 373:231-239.
26. Basak A, Cooper S, Roberge AG, Banik UK, Chrétien M, Seidah NG (1999) Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J 338:107-113.
27. Chiou WF, Lin JJ, Chen CF (1998) Andrographolid suppresses the expression of inducible nitric oxide synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide. Br J Pharmacol 125:327-334.
28. Handa SS, Sharma A (1990) Hepatoprotective activity of andrographolid from Andrographis paniculata against carbontetrachloride. Indian J Med Res 92:276-283.
29. Choudhury BR, Poddar MK (1984) Andrographolid and kalmegh (Andrographis paniculata) extract: in vivo and in vitro effect on hepatic lipid peroxidation. Methods Find Exp Clin Pharmacol 6:481-485.
30. Amroyan E, Gabrielian E, Panossian A, Wikman G, Wagner H (1999) Inhibitory effect of andrographolid from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine, 6:27-31.
31. Visen PK, Shukla B, Patnaik GK, Dhawan BN (1993) Andrographolid protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol 40:131-136.
32. Shukla B, Visen PK, Patnaik GK, Dhawan BN (1992) Choleretic effect of andrographolid in rats and guinea pigs. Planta Med 58:146-149.
33. Aminuddin A, Girach RD (1991) (Surv Medicinal Plants Unit, Regl Res Inst Unani Med, Bhadrak 756100). Ethnobotanical studies on Bondo tribe of district Koraput (Orissa), India. Ethnobotany 3 (1&2):15-19.
34. Zhang CY, Tan BK (1997) Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 56:97-101.
35. Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tandon JS (1993) Immunostimulant agents from Andrographis paniculata. J Nat Product 56:995-999.
36. Choudhury BR, Poddar MK (1985) Andrographolid and kalmegh (Andrographis paniculata) extract: Effect on intestinal brush-border membrane-bound hydrolases. Methods Find Exp Clin Pharmacol 7:617-621.
37. Panossian A, Kochikian A, Gabrielian E, Muradian R, Stepanian H, Arsenian F, Wagner H (1999) Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats. Phytomedicine 6:157-161.
38. Kapil A, Koul IB, Banerjee SK, Gupta BD (1993) Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol 46:182-185.
39. Choudhury BR, Haque SJ, Poddar MK (1987) In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and andrographolid on hepatic microsomal drug metabolizing enzymes. Planta Med. 53:135-140.
40. Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK (1999) Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phytomedicine 6:217-223.
41. Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A, Nishi K (1994) Cell differentiationinducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo). 42:1216-1225.
42. Mehrotra R, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN (1990) In vitro studies on the effect of certain natural products against hepatitis B virus. Indian J Med Res 92:133-138.
43. Chang RS, Ding L, Chen GQ, Pan QC, Zhao ZL, Smith KM (1991) Dehydroandrographolid succinic acid monoester as an inhibitor against the human immunodeficiency virus. Proc Soc Exp Biol Med 197:59-66.
44. Seidah NG, Benjannet S, Pareek S, Chretien M, Murphy RA (1996) Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Lett 379:248-250.
45. Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Lalibete J, Lazure C, Chretien M, Murphy RA (1996) Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochem J 314:951-960.
46. Mowla SJ, Pareek S, Farhadi HF, Petrecca K, Fawcett JP, Seidah NG, Morris SJ, Sossin WS, Murphy RA (1999) Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons. J Neurosci 19:2069-2080.
47. Yan Q, Rosenfeld RD, Matheson CR, Hawkins N, Lopez OT, Bennett L, Welcher AA (1997) Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience 78:431-448.
48. Wouters S, Decroly E, Vandenbranden M, Shober D, Fuchs R, Morel V, Leruth M, Seidah NG, Courtoy PJ, Ruysschaert JM (1999) Occurrence of an HIV-1 gp160 endoproteolytic activity in low-density vesicles and evidence for a distinct density distribution from endogenously expressed furin and PC7/LPC convertases. FEBS Lett 456:97-102.
49. Vollenweider F, Benjannet S, Decroly E, Savaria D, Lazure C, Thomas G, Chretien M, Seidah NG (1996) Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases. Biochem J 314:521-532.
50. Pedersen JR, Olsson JO (2003) Soxhlet extraction of acrylamide from potato chips. Analyst 128:332-334.
51. Basak A, Zhong M, Munzer JS, Chretien M, Seidah NG (2001) Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: A comparative analysis with fluorogenic peptides. Biochem J 353:537-545.
52. Basak A, Li S, Banik UK (2003) A new combination drugs using andrographolid derived natural product Restomune for management of HIV: A case study. Case Reports and Clinical Practice Review 4:223-233.
53. Chang RS, Yeung HW (1988) Inhibition of growth of human immunodeficiency virus in vitro by crude extracts of Chinese medicinal herbs. Antiviral Research 9:163-176 (http://www.aids.org/atn/a-061-04.html).
54. Bassi DE, Lopez De Cicco R, Mahloogi H, Zucker S, Thomas G, Klein-Szanto AJ (2001) Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. Proc Natl Acad Sci USA 98:10326-10331.
55. http://www.geocities.com/andrographis/AndroBaseText.txt.
56. Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R (2003) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 3:147-158.
57. Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A, Nishi K (1994) Cell differentiationinducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo) 42:1216-1225.
58. Lan MT, Sifzizul Muhammad TST, Kuroyanagi M, Sulaiman SF, Najimuddn N: Determination of growth inhibitory activities of several bioactive compounds of Andrographis paniculata a panel of human tumor cell lines: 14-deoxy-11, 12- didehydroandrographolid induces a non-apoptotic programmed cell death in T-47D, a breast carcinoma cell line. www.usm.my/nsf/sample%20full%20paper3-20Sept.pdf.