Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Sorrentino, Sacha ^a   Bucciarelli, Tonino ^d   Corsaro, Alessandro ^b   Tosatto, Alessio ^a   Thellung, Stefano ^b   Villa, Valentina ^b   Schininà, M Eugenia ^c   Maras, Bruno ^c   Galeno, Roberta ^e   Scotti, Luca ^d   Creati, Francesco ^d   Marrone, Alessandro ^d   Re, Nazzareno ^d   Aceto, Antonio ^d   Florio, Tullio ^b   Mazzanti, Michele ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF CHIETI   (Italy)

^e ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; PRION PROTEIN; PROTEINASE K;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CELL DEGENERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY TEST; HUMAN; HUMAN CELL; ION CONDUCTANCE; MEMBRANE CONDUCTANCE; MEMBRANE PERMEABILITY; NEUROTOXICITY; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN UNFOLDING;

AMINO ACIDS; ANIMALS; BINDING SITES; CALCIUM; CELL DEATH; CRICETINAE; ENDOPEPTIDASE K; HUMANS; ION TRANSPORT; LIPID BILAYERS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PRIONS; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY;

MESOCRICETUS AURATUS;

EID: 84863846979     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038314     Document Type: Article

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